INT111100

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 14.81
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Dusp1) nucleoplasm (Dusp1) nucleus (Dusp1)
cell cycle (Dusp1)
Anatomy Link Frequency
lung 1
wound epidermis 1
Dusp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 100 100.00 Very High Very High Very High
dexamethasone 364 99.82 Very High Very High Very High
addiction 231 99.28 Very High Very High Very High
Inflammatory response 108 98.66 Very High Very High Very High
Lasting pain 23 98.64 Very High Very High Very High
cocaine 270 96.64 Very High Very High Very High
Inflammation 326 96.40 Very High Very High Very High
cytokine 14 95.88 Very High Very High Very High
alcohol 208 95.68 Very High Very High Very High
drug abuse 69 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 128 100.00 Very High Very High Very High
Congenital Anomalies 45 99.96 Very High Very High Very High
Injury 173 99.78 Very High Very High Very High
Asthma 33 99.04 Very High Very High Very High
Aids-related Complex 71 98.90 Very High Very High Very High
Pancreatic Cancer 209 98.84 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 324 98.82 Very High Very High Very High
INFLAMMATION 446 98.48 Very High Very High Very High
Cognitive Disorder 120 98.20 Very High Very High Very High
Targeted Disruption 11 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Suppression of MKP-1 expression reduces the tumorigenicity of pancreatic cancer cells in vivo, suggesting that MKP-1 contributes to enhanced mitogenic signaling in pancreatic cancer cells.


Gene_expression (expression) of MKP-1
1) Confidence 0.76 Published 2003 Journal Gastroenterology Section Body Doc Link 12806617 Disease Relevance 0 Pain Relevance 0
In view of the important role of MAPK kinase phosphatase (MKP)-1 in the regulation of MAPK activation, the expression and functional role of MKP-1 was analyzed.
Spec (analyzed) Gene_expression (expression) of MKP-1
2) Confidence 0.76 Published 2003 Journal Gastroenterology Section Abstract Doc Link 12806617 Disease Relevance 0.25 Pain Relevance 0.09
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Gene_expression (expression) of DUSP1 in lung associated with inflammation, aids-related complex and cytokine
3) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.09 Pain Relevance 0.17
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of dusp1 associated with inflammatory response
4) Confidence 0.61 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.85 Pain Relevance 0.34
In situ hybridization shows that the front few rows of wound epidermis express MKP-1, although expression extends less far back from the wound edge than for Krox24 (Figure 4d).
Gene_expression (express) of MKP-1 in wound epidermis associated with injury
5) Confidence 0.38 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.48 Pain Relevance 0
Thus, treatment with a GC alone or combined with chemotherapy led to an increased protein expression of SGK-1 and MKP-1 while specific inhibition of these molecules by small interfering RNA reversed the anti-apoptotic effects of GC treatment in breast cancer cells [15].
Gene_expression (expression) of MKP-1 associated with breast cancer and apoptosis
6) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.71 Pain Relevance 0.22
The membranes were then rinsed and incubated in the rabbit polyclonal antibodies MKP-1, BAG-1 (both from Santa Cruz, Heidelberg, Germany), SGK-1 (Stressgene, Victoria, Canada), X-IAP (New England Biolabs/Cell Signaling, Frankfurt, Germany) or in the mouse monoclonal antibodies: BCL-2 (Merck/Calbiochem, Darmstadt, Germany), ACTIN (clone C4, ICN, Aurora, Ohio, USA).
Gene_expression (rinsed) of MKP-1
7) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.29 Pain Relevance 0.06
There was, however, an interaction between pain status and the Met allele (N2-component of C4), indicating that the effect of the COMT Met allele on the pain ERP was moderated by the presence of chronic pain complaints.
Gene_expression (effect) of ERP associated with pain and lasting pain
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.86 Pain Relevance 1.75
Since enhanced expression of MKP-1 and SGK-1 has been recently described to be involved in DEX-induced resistance in established breast cancer cell lines [15], we examined expression of these pro-survival molecules in pancreatic cancer cells by Western blot analysis together with expression of the anti-apoptotic molecules X-IAP and Bcl-2.
Gene_expression (expression) of MKP-1 associated with pancreatic cancer, breast cancer, apoptosis and dexamethasone
9) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.70 Pain Relevance 0.21
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
Gene_expression (levels) of MKP-1 associated with pancreatic cancer and dexamethasone
10) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.62 Pain Relevance 0.24
Therefore, enhanced expression of MKP-1, SGK-1, X-IAP and Bcl-2 but not of BAG-1 may be involved in DEX-induced therapy resistance of pancreatic carcinomas.


Gene_expression (expression) of MKP-1 associated with pancreatic cancer and dexamethasone
11) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.83 Pain Relevance 0.24
Additionally, JNK activity appears to be inversely related to MKP-1 expression.
Gene_expression (expression) of MKP-1
12) Confidence 0.10 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.91 Pain Relevance 0.03
Another study showed that over expression of MKP-1 and DU145 cells blocked the activation of JNK [69].
Gene_expression (expression) of MKP-1
13) Confidence 0.10 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.50 Pain Relevance 0
A study looking at patients with severe asthma vs nonsevere asthma found a reduction in the dexamethasone-induced expression (messenger RNA) of MKP-1 and elevation in p38 activity in patients with severe asthma compared with patients with nonsevere asthma.92 However, no studies have looked at the GC-mediated induction of MKP-1 in COPD, and consequently no links have yet been made between the expression, activity, or signaling of MKP-1 and the reduction in GC responsiveness in COPD, although the potential is clearly explained.
Gene_expression (expression) of MKP-1 associated with asthma, chronic obstructive pulmonary disease and dexamethasone
14) Confidence 0.07 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.08 Pain Relevance 0.11
in an induction of MAPK phosphatase-1 (MKP-1) expression, which reduced p38 MAPK activity by dephosphorylation (REF).
Gene_expression (expression) of MKP-1
15) Confidence 0.07 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.03 Pain Relevance 0.11
In most ERP studies the P300 did not differentiate among patients characterized by histories of either cocaine, or cocaine and alcohol, or heroin dependence.
Gene_expression (studies) of ERP associated with addiction, opiate addiction, alcohol and cocaine
16) Confidence 0.07 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.31 Pain Relevance 0.68
In early reviews of EEG and ERP studies of acute and chronic THC exposure in humans (Struve et al. 1989, 1994), it was reported that significant associations between chronic exposure and clinically abnormal EEG patterns had not been demonstrated and that attempts to use visual EEG analyses to detect transient acute THC exposure induced EEG alterations failed to demonstrate consistent THC–EEG effects across studies.
Gene_expression (exposure) of ERP
17) Confidence 0.07 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.42 Pain Relevance 0.23
qEEG and ERP Abnormalities in Addiction: Psychopharmacological Effects or Trait Markers?
Gene_expression (qEEG) of ERP associated with addiction and congenital anomalies
18) Confidence 0.07 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.94 Pain Relevance 0.66
A study looking at patients with severe asthma vs nonsevere asthma found a reduction in the dexamethasone-induced expression (messenger RNA) of MKP-1 and elevation in p38 activity in patients with severe asthma compared with patients with nonsevere asthma.92 However, no studies have looked at the GC-mediated induction of MKP-1 in COPD, and consequently no links have yet been made between the expression, activity, or signaling of MKP-1 and the reduction in GC responsiveness in COPD, although the potential is clearly explained.
Gene_expression (expression) of MKP-1 associated with asthma, chronic obstructive pulmonary disease and dexamethasone
19) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.93 Pain Relevance 0.07

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