INT111143

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 5.65
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
stem cells 3
plasma 2
B-cell 2
body 2
plasma cells 1
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 82 100.00 Very High Very High Very High
Nav1.7 13 95.88 Very High Very High Very High
rheumatoid arthritis 84 94.16 High High
Inflammation 38 92.32 High High
abdominal pain 2 92.20 High High
methotrexate 23 86.56 High High
imagery 5 84.24 Quite High
tetrodotoxin 23 75.44 Quite High
Pain 11 75.20 Quite High
Arthritis 81 74.64 Quite High
Disease Link Frequency Relevance Heat
Thymoma 17 98.80 Very High Very High Very High
Systemic Lupus Erythematosus 63 97.56 Very High Very High Very High
Stress 25 96.00 Very High Very High Very High
Cancer 113 95.20 Very High Very High Very High
Disease 80 94.92 High High
Rheumatoid Arthritis 86 94.16 High High
Reprotox - General 1 54 93.84 High High
Splenomegaly 1 92.76 High High
INFLAMMATION 37 92.32 High High
Abdominal Pain 2 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Keratin K13 is also expressed in the urothelium as a major component of the basal and intermediate cells whereas it is lost in the superficial umbrella cells (that switch on K20 expression; see above).
Regulation (switch) of Gene_expression (expression) of K20
1) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
Since immunosuppressive therapy may influence the presence of CD27++/CD20?
Spec (may) Regulation (influence) of Gene_expression (presence) of CD20
2) Confidence 0.14 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.89 Pain Relevance 0
Administration of rituximab leads to selective depletion of the CD20 positive B cells from the body, leaving the stem cells and plasma cells unaffected because CD20 is not expressed on these cells.
Neg (unaffected) Regulation (unaffected) of Neg (not) Gene_expression (expressed) of CD20 in stem cells
3) Confidence 0.09 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581826 Disease Relevance 0.43 Pain Relevance 0.36
The production of the serum protein albumin is affected by the induction of acute-phase proteins such as CRP (Fig. 2, top panel).
Regulation (affected) of Gene_expression (production) of protein
4) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.21 Pain Relevance 0.23
Administration of rituximab leads to selective depletion of the CD20 positive B cells from the body, leaving the stem cells and plasma cells unaffected because CD20 is not expressed on these cells.
Neg (unaffected) Regulation (unaffected) of in plasma cells Neg (not) Gene_expression (expressed) of CD20 in stem cells
5) Confidence 0.03 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581826 Disease Relevance 0.43 Pain Relevance 0.36
Further study is also needed to determine whether the differences in relative protein expression identified in cultured HCEC are also present in HCEC in vivo.
Spec (whether) Regulation (present) of Gene_expression (expression) of protein
6) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2565687 Disease Relevance 0 Pain Relevance 0
Posttranslational regulation of protein levels may also be responsible for some differences.
Regulation (regulation) of Gene_expression (levels) of protein
7) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2565687 Disease Relevance 0.15 Pain Relevance 0
Furthermore, the diagnostic value of the co-expression of cytokeratins and CD20 was considered.
Regulation (value) of Gene_expression (expression) of CD20
8) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2903530 Disease Relevance 1.12 Pain Relevance 0
Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda.
Regulation (population) of Gene_expression (coexpressing) of CD20 in B-cell
9) Confidence 0.03 Published 2003 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 12810261 Disease Relevance 0.43 Pain Relevance 0.09
Review of the data obtained in this study provides insight into changes in relative protein expression that suggest an age-related reduction in the ability of cultured HCEC to protect against oxidative stress and to maintain general cellular health.
Regulation (changes) of Gene_expression (expression) of protein associated with stress
10) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2565687 Disease Relevance 0.31 Pain Relevance 0
Auto-regulation of VGSC protein expression
Regulation (regulation) of Gene_expression (expression) of VGSC protein associated with sodium channel
11) Confidence 0.00 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.18 Pain Relevance 0.88
The effect of protein composition on skeletal muscular protein synthesis
Regulation (effect) of Gene_expression (synthesis) of protein
12) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.08 Pain Relevance 0
This further supports the contention that extra cellular EAAs are responsible for protein synthesis irrespective of NEAA concentrations.
Regulation (responsible) of Gene_expression (synthesis) of protein
13) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.08 Pain Relevance 0
It appears that extra cellular concentrations of essential amino acids (EAA) serve as regulators of protein synthesis.
Regulation (regulators) of Gene_expression (synthesis) of protein
14) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.07 Pain Relevance 0
This was supported by Tipton et al. [81] who found that 40 grams of EAAs did not increase the effect of protein synthesis as compared to a 40 gram mixture of 20 grams of EAAs and 20 grams of NEAAs.
Regulation (effect) of Gene_expression (synthesis) of protein
15) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
In vitro studies [93-95] have supported insulin's role in regulating protein synthesis, while a number of in vivo studies have shown discrepancies in protein synthesis [96].
Regulation (regulating) of Gene_expression (synthesis) of protein
16) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
In this context Borsheim, Tipton., Wolf, and Wolfe. [62] investigated the effects of 6 grams of EAAs and 6 grams of mixed EAAs and NEAAs (approximately 3 grams of each) on protein synthesis in two doses spaced 1 hour apart.
Spec (investigated) Regulation (effects) of Gene_expression (synthesis) of protein
17) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
These results suggest that the machinery responsible for protein synthesis becomes refractory to a prolonged elevation in plasma amino acids, at least when the concentration is maintained.
Regulation (responsible) of Gene_expression (synthesis) of protein in plasma
18) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.07 Pain Relevance 0
As has been discussed splanchnic tissues are largely responsible for whole body protein synthesis [72,73].
Regulation (responsible) of Gene_expression (synthesis) of protein in body
19) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
The effect of protein composition on peripheral and splanchnic tissue protein synthesis
Regulation (effect) of Gene_expression (synthesis) of protein
20) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0

General Comments

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