INT111153

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.56
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
joint 2
synovial fluid 2
hip 2
knee 1
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 13 100.00 Very High Very High Very High
Osteoarthritis 490 98.64 Very High Very High Very High
rheumatoid arthritis 14 95.32 Very High Very High Very High
antagonist 30 88.68 High High
Arthritis 14 84.36 Quite High
Bile 1 78.56 Quite High
cytokine 11 74.24 Quite High
Kinase C 26 72.96 Quite High
spinal inflammation 11 50.00 Quite Low
pain pelvic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 13 100.00 Very High Very High Very High
Cancer 95 99.84 Very High Very High Very High
Osteophyte 42 99.80 Very High Very High Very High
Disease 239 98.92 Very High Very High Very High
Metastasis 45 98.92 Very High Very High Very High
Osteoarthritis 490 98.64 Very High Very High Very High
Arthropathy 42 98.04 Very High Very High Very High
Amyloid Plaque 12 96.00 Very High Very High Very High
Reprotox - General 1 26 95.80 Very High Very High Very High
Rheumatoid Arthritis 14 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although synovial fluid Dkk-1 levels in KL grade 2 were elevated compared with those of KL grade 3, the difference was not significant (p = 0.4).
Positive_regulation (elevated) of Dkk-1 in synovial fluid
1) Confidence 0.68 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.40 Pain Relevance 0.17
Patients with AS studied serially prior to and following anti-TNFalpha administration exhibited a significant increase in serum Dkk-1 levels (P = 0.020), in contrast to patients with RA, who exhibited a dramatic decrease (P < 0.001).
Positive_regulation (increase) of Dkk-1
2) Confidence 0.53 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20039407 Disease Relevance 0.11 Pain Relevance 0
RESULTS: Serum Dkk-1 levels were significantly increased in patients with AS (mean +/- SEM 2,730 +/- 135.1 pg/ml) as compared with normal subjects (P = 0.040), patients with RA (P = 0.020), and patients with PsA (P = 0.049).
Positive_regulation (increased) of Dkk-1
3) Confidence 0.53 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20039407 Disease Relevance 0.15 Pain Relevance 0
Furthermore, decreased Dkk-1 levels tend to be essential for osteophyte formation, suggesting that Wnt signaling is a critical initiator for bone formation in the joint.
Positive_regulation (essential) of Dkk-1 in joint associated with osteophyte
4) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.13 Pain Relevance 0.32
In concordance with our findings, Voorzanger-Rousselot and coworkers have revealed that circulating Dkk-1 levels were lower in patients with knee OA compared with healthy controls [26].
Positive_regulation (circulating) of Dkk-1 in knee associated with osteoarthritis
5) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.15 Pain Relevance 0.51
Recently, elevated circulating Dkk-1 levels have been associated with delayed progression of radiographic hip OA in women [12].
Positive_regulation (circulating) of Dkk-1 in hip associated with osteoarthritis
6) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.89 Pain Relevance 0.33
Recently, elevated circulating Dkk-1 levels have been associated with delayed progression of radiographic hip OA in women [12].
Positive_regulation (elevated) of Dkk-1 in hip associated with osteoarthritis
7) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.90 Pain Relevance 0.33
The data showed that synovial fluid Dkk-1 levels in KL grade 2 and 3 were significantly elevated compared with those of KL grade 4 (p = 0.04).
Positive_regulation (elevated) of Dkk-1 in synovial fluid
8) Confidence 0.46 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.33 Pain Relevance 0.14
Previous reports have demonstrated that increased Dkk-1 levels were correlated with the pathogenesis of joint disorders [10,26,27].
Positive_regulation (increased) of Dkk-1 in joint associated with arthropathy
9) Confidence 0.46 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.98 Pain Relevance 0.35
Furthermore, Dkk-1 serum levels are elevated in CaM patients with bone metastases, but not in CaM patients with soft tissue metastases, and it has been suggested that Dkk-1-induced inhibition of bone formation may contribute to the osteolytic lesion in CaM [55].
Positive_regulation (elevated) of Dkk-1 associated with cancer and metastasis
10) Confidence 0.27 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 2.44 Pain Relevance 0.04
These studies indicate that induction of Dkk-1 contributes to the pathological cascade triggered by A?
Positive_regulation (induction) of Dkk-1
11) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.81 Pain Relevance 0
Dkk-1 was induced at later times after A?
Positive_regulation (induced) of Dkk-1
12) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.48 Pain Relevance 0.13
Group 1 target genes are up-regulated during the normal window of implantation but significantly decreased in women with endometriosis: IL-15, proline-rich protein, B61, Dickkopf-1, glycodelin, N-acetylglucosamine-6-O-sulfotransferase, G0S2 protein, and purine nucleoside phosphorylase.
Positive_regulation (up-regulated) of Dickkopf-1 associated with endometriosis
13) Confidence 0.02 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.79 Pain Relevance 0.28

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