INT111155

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.54
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (G0s2)
Anatomy Link Frequency
HDF 2
lipid droplets 1
lymphocytes 1
G0s2 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 20 100.00 Very High Very High Very High
psoriasis 14 99.24 Very High Very High Very High
rheumatoid arthritis 77 98.96 Very High Very High Very High
agonist 30 96.00 Very High Very High Very High
pain pelvic 8 95.12 Very High Very High Very High
Bile 10 78.56 Quite High
Inflammation 49 73.92 Quite High
ischemia 14 66.96 Quite High
Inflammatory mediators 8 60.72 Quite High
cytokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 20 100.00 Very High Very High Very High
Targeted Disruption 189 99.96 Very High Very High Very High
Disease 66 99.62 Very High Very High Very High
Vasculitis 616 99.32 Very High Very High Very High
Psoriasis 14 99.24 Very High Very High Very High
Obesity 14 99.12 Very High Very High Very High
Rheumatoid Arthritis 77 98.96 Very High Very High Very High
Autoimmune Disease 112 98.56 Very High Very High Very High
Aging 14 97.42 Very High Very High Very High
Reprotox - General 3 19 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then showed by RT–PCR analysis that EGR1, G0S2, HBD, TVAS10, IL1R2, Amphiregulin, and calgranulin C are frequently upregulated in the PBMCs of vasculitis patients (Fig. 1 and Supplementary Fig.
Positive_regulation (upregulated) of G0S2 associated with vasculitis
1) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.10 Pain Relevance 0.04
Moreover, it was shown that G0S2 is upregulated after PPAR?
Positive_regulation (upregulated) of G0S2
2) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.88 Pain Relevance 0.19
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Positive_regulation (increased) of G0S2 in HDF associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
3) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.04 Pain Relevance 0.23
Notably, relative to healthy controls, G0S2 expression is also enhanced in the PBMCs from patients with other autoimmune diseases, namely SLE4 and RA.5 Microarray and qRT–PCR analyses also showed that G0S2 is upregulated in the PBMCs from psoriasis patients suffering from severe generalized disease.13 Thus, it may be interesting to analyze G0S2 further, as it may shed light on the pathogenesis of vasculitis at the molecular level (see below).
Positive_regulation (upregulated) of G0S2 associated with psoriasis, autoimmune disease, rheumatoid arthritis, vasculitis and disease
4) Confidence 0.46 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.32 Pain Relevance 0.13
We prepared anti-G0S2 antibodies and then generated G0S2 transgenic mice and examined their phenotype.
Positive_regulation (generated) of G0S2 associated with targeted disruption
5) Confidence 0.43 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.63 Pain Relevance 0.04
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Positive_regulation (upregulation) of G0S2 in lymphocytes associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
6) Confidence 0.40 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.05 Pain Relevance 0.24
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Positive_regulation (upregulated) of G0S2 in fibroblasts associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
7) Confidence 0.40 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.33 Pain Relevance 0.25
Interestingly, the G(0)/G(1) switch gene 2 (G0s2) was recently identified as an inhibitor of Pnpla2 activity and located to lipid droplets in adipocytes stimulated with ?
Positive_regulation (located) of G0s2 in lipid droplets associated with obesity
8) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.40 Pain Relevance 0.13
Group 1 target genes are up-regulated during the normal window of implantation but significantly decreased in women with endometriosis: IL-15, proline-rich protein, B61, Dickkopf-1, glycodelin, N-acetylglucosamine-6-O-sulfotransferase, G0S2 protein, and purine nucleoside phosphorylase.
Positive_regulation (up-regulated) of G0S2 protein associated with endometriosis
9) Confidence 0.01 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.80 Pain Relevance 0.28

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