INT11118

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 9.35
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (RAPGEF5) intracellular (RAPGEF5)
Anatomy Link Frequency
Kidney 2
plasma 1
muscle 1
arm 1
RAPGEF5 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 18 99.88 Very High Very High Very High
Inflammation 59 99.32 Very High Very High Very High
beta blocker 18 86.64 High High
aspirin 34 81.56 Quite High
cINOD 6 57.92 Quite High
Angina 10 55.32 Quite High
Pain 19 54.96 Quite High
addiction 3 48.28 Quite Low
cva 12 26.40 Quite Low
Calcium channel 17 24.04 Low Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 44 100.00 Very High Very High Very High
Renal Disease 249 99.88 Very High Very High Very High
Fibrosis 9 99.88 Very High Very High Very High
Chronic Renal Failure 124 99.84 Very High Very High Very High
Proteinuria 121 99.68 Very High Very High Very High
Injury 16 99.42 Very High Very High Very High
INFLAMMATION 66 99.32 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 223 99.16 Very High Very High Very High
Vomiting 5 98.78 Very High Very High Very High
Albuminuria 47 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that chronic inanition due to surreptitious vomiting causes impaired renal diluting ability through decreases in GFR and RPF, irrespective of the levels of plasma AVP and ANP.
Gene_expression (irrespective) of GFR in plasma associated with disorders of creatine metabolism and vomiting
1) Confidence 0.65 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.89 Pain Relevance 0.05
Kidney disease was classified according to National Kidney Foundation Disease Outcome Quality Initiative (NKF/DOQI) Advisory Board criteria, which define stage I chronic kidney disease (CKD) as GFR >or= 90 mL/min/1.73 m(2), stage II as 60-89 mL/min/1.73 m(2), stage III as 30-59 mL/min/1.73 m(2), stage IV as 15-29 mL/min/1.73 m(2), and stage V as < 15 mL/min/1.73 m(2).
Gene_expression (classified) of GFR in kidney
2) Confidence 0.65 Published 2009 Journal Ren Fail Section Body Doc Link 19925283 Disease Relevance 0.08 Pain Relevance 0
It has long been known that cystatin C levels are not highly influenced by confounding factors, such as diet, nutrition, or inflammatory status, whereas measurements for GFR based on creatinine levels, including the MDRD or C&G formulas, have substantial limitations such as age, sex, muscle mass, ethnicity, and methodology of determining serum creatinine level (1) However, cystatin C production was not thought to be affected by any factors until several authors demonstrated that serum cystatin C could be affected by both rheumatoid factor (22) and high doses of glucocorticoid (23).
Gene_expression (based) of GFR in muscle associated with inflammation
3) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 0.28 Pain Relevance 0.05
Recently, Herget-Rosenthal and his colleagues found that determining cystatin C levels is a more sensitive test for the early detection of renal function impairment or reduced GFR (1).
Gene_expression (detection) of GFR
4) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2800003 Disease Relevance 1.14 Pain Relevance 0.04
Outcomes according to the estimated GFR
Gene_expression (Outcomes) of GFR
5) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 1.22 Pain Relevance 0.08
The average of these six collections was expressed as the GFR.


Gene_expression (expressed) of GFR
6) Confidence 0.26 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 0.60 Pain Relevance 0.11
Proteinuria has emerged as a major determinant in the development of progressive tubular injury, interstitial fibrosis, and GFR loss in CKD (Remuzzi et al 2006), as well as Fabry nephropathy (Schiffmann 2007; Warnock 2007).
Gene_expression (loss) of GFR associated with fibrosis, chronic renal failure, renal disease, injury and proteinuria
7) Confidence 0.25 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 1.46 Pain Relevance 0.09
The National Kidney Foundation classification (Table 15) is primarily based on GFR levels and therefore differs from other systems, in which staging is based primarily on urinary albumin excretion (284).
Gene_expression (levels) of GFR in Kidney
8) Confidence 0.06 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.85 Pain Relevance 0
Again, a greater reduction in proteinuria, as observed in the benazepril/HCTZ arm of GUARD, does not necessarily translate into greater renoprotection, as expressed by the slope of GFR reduction.
Gene_expression (reduction) of GFR in arm associated with proteinuria
9) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.46 Pain Relevance 0
In any case, combination therapy with ACE inhibitors and CCBs may reduce the slope of GFR reduction.114


Gene_expression (reduction.114) of GFR
10) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.44 Pain Relevance 0
Wong et al. valued measure GFR and serum cystatin C (Cys C) levels in 18 children with ADPKD versus 41?
Gene_expression (levels) of GFR associated with autosomal dominant polycystic kidney
11) Confidence 0.05 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.82 Pain Relevance 0
Wong et al. valued measure GFR and serum cystatin C (Cys C) levels in 18 children with ADPKD versus 41?
Gene_expression (serum) of GFR associated with autosomal dominant polycystic kidney
12) Confidence 0.05 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.80 Pain Relevance 0
Median GFR was not different between the two treatment groups at baseline (agalsidase alfa: 99 ml/min, range 22 to 136, agalsidase beta: 108, range 53 to 154, p?
Neg (not) Gene_expression (different) of GFR
13) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1913555 Disease Relevance 0.24 Pain Relevance 0
Relationship between e-GFR and AVP, c-AMP and AQP2
Gene_expression (e-GFR) of e-GFR
14) Confidence 0.01 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2965705 Disease Relevance 0.05 Pain Relevance 0

General Comments

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