INT111186

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.44
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GIPC1) protein targeting (GIPC1) cytoplasmic membrane-bounded vesicle (GIPC1)
cytoplasm (GIPC1)
Anatomy Link Frequency
pancreas 1
GIPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 99.78 Very High Very High Very High
Chronic pancreatitis 6 99.48 Very High Very High Very High
Pain 2 97.56 Very High Very High Very High
opioid receptor 2 95.84 Very High Very High Very High
abdominal pain 1 83.12 Quite High
Central nervous system 1 80.68 Quite High
antidepressant 1 79.24 Quite High
Opioid 5 76.12 Quite High
spastic colon 5 76.04 Quite High
Lasting pain 1 73.00 Quite High
Disease Link Frequency Relevance Heat
Disease 3 99.50 Very High Very High Very High
Pancreatitis 7 99.48 Very High Very High Very High
Pain 2 97.56 Very High Very High Very High
Adenocarcinoma 44 94.20 High High
Cancer 96 89.12 High High
Abdominal Pain 1 83.12 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 76.04 Quite High
Functional Bowel Disorder 2 75.84 Quite High
Viral Infection 5 64.00 Quite High
Pancreatic Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cluster 2b displayed a profile diametrically opposite to that of normal pancreas or chronic pancreatitis and was characterized by upregulation of ISG and IIP genes, while all IFN (including IFN-alpha4,5,7,17, IFN-beta1, IFN-omega1) and several IFN receptor genes (including IFN-alpha, beta and omega receptor 1, IFNalphabeta and omega receptor 2) were down regulated.
Positive_regulation (upregulation) of IIP in pancreas associated with chronic pancreatitis
1) Confidence 0.67 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.57 Pain Relevance 0.23
The main findings were: (1) difficulties with social inhibition and dependency were associated with longer disease duration; (2) change in mean IIP-32 over 15 months was significantly correlated with changes in pain, but these relationships were mediated by change in psychological distress; (3) change in IIP-32 was an independent predictor of improved health status at 15 months only in the psychotherapy group.
Positive_regulation (mean) of IIP-32 associated with pain and disease
2) Confidence 0.19 Published 2009 Journal Pain Section Abstract Doc Link 19643544 Disease Relevance 0.50 Pain Relevance 0.59
We calculated that the anti-NIP trimerbody has at least a 100-fold increase in apparent functional affinity for NIP-BSA conjugates compared to its monovalent counterpart.
Positive_regulation (increase) of NIP
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670539 Disease Relevance 0.21 Pain Relevance 0.03
Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation.
Positive_regulation (activation) of terminus associated with mu opioid receptor
4) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12810704 Disease Relevance 0 Pain Relevance 0.60

General Comments

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