INT111189

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PPL) plasma membrane (PPL) cytoskeleton (PPL)
nucleus (PPL) cytoplasm (PPL)
Anatomy Link Frequency
kidney 1
PPL (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 100.00 Very High Very High Very High
opioid receptor 2 94.68 High High
Bile 3 85.84 High High
Central nervous system 1 79.52 Quite High
Opioid 5 74.96 Quite High
agonist 4 69.56 Quite High
imagery 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 59 100.00 Very High Very High Very High
Polycystic Kidney Disease 4 100.00 Very High Very High Very High
Cystadenoma 1 90.00 High High
Cystadenocarcinoma 1 88.72 High High
Malignant Neoplastic Disease 1 84.68 Quite High
Death 1 82.84 Quite High
Sepsis 2 81.92 Quite High
Pancreatic Cancer 6 76.64 Quite High
Toxicity 4 24.56 Low Low
Adenocarcinoma 8 22.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation.
periplakin Binding (interactions) of associated with mu opioid receptor
1) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12810704 Disease Relevance 0 Pain Relevance 0.59
Periplakin, a member of the plakin family of proteins, has been recently characterized by complementary deoxyribonucleic acid (cDNA) cloning, and the corresponding gene,…
Periplakin Binding (characterized) of
2) Confidence 0.36 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2859134 Disease Relevance 0 Pain Relevance 0
We have examined for any possible association between polycystic kidney disease and PPL, given the existence of both conditions in case two.
PPL Binding (association) of in kidney associated with lymphatic system cancer and polycystic kidney disease
3) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475874 Disease Relevance 1.33 Pain Relevance 0.04

General Comments

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