INT111192

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.27
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PPL) plasma membrane (PPL) cytoskeleton (PPL)
nucleus (PPL) cytoplasm (PPL)
Anatomy Link Frequency
lung 3
diaphragm 2
upper 1
PPL (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 99.54 Very High Very High Very High
opioid receptor 2 95.84 Very High Very High Very High
Bile 5 82.56 Quite High
Central nervous system 1 80.68 Quite High
imagery 7 79.28 Quite High
abdominal pain 3 77.84 Quite High
Opioid 5 76.12 Quite High
agonist 4 70.72 Quite High
vincristine 3 52.48 Quite High
depression 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 109 100.00 Very High Very High Very High
Pancreatic Cancer 9 99.16 Very High Very High Very High
Cancer 22 98.54 Very High Very High Very High
Adult Respiratory Distress Syndrome 252 98.00 Very High Very High Very High
Adenocarcinoma 17 96.96 Very High Very High Very High
Lymphoproliferative Disease 1 95.40 Very High Very High Very High
Lung Injury 18 86.72 High High
Pressure And Volume Under Development 19 81.40 Quite High
Cyst 2 79.92 Quite High
Myocardial Infarction 12 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ca19-9 is the most useful tumour marker in pancreatic carcinoma, but can be misleading as it may also be elevated in other malignancies, particularly of the upper gastrointestinal tract, including PPL as described in case one [11].
Positive_regulation (elevated) of PPL in upper associated with lymphatic system cancer, cancer and pancreatic cancer
1) Confidence 0.60 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475874 Disease Relevance 1.30 Pain Relevance 0.08
Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation.
Positive_regulation (activation) of periplakin associated with mu opioid receptor
2) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12810704 Disease Relevance 0 Pain Relevance 0.60
Serum carbohydrate antigen 19-9 (CA 19-9) level in patients with PPL is usually not elevated.
Neg (not) Positive_regulation (elevated) of PPL associated with lymphatic system cancer
3) Confidence 0.30 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396657 Disease Relevance 1.64 Pain Relevance 0.13
During sustained increases in lung volume, the increase in Ppl is greater than the increase in Ppc.
Positive_regulation (increase) of Ppl in lung
4) Confidence 0.23 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.29 Pain Relevance 0
The primary determinant of the increase in Ppl and Ppc during positive-pressure ventilation is lung volume change [11].
Positive_regulation (increase) of Ppl in lung
5) Confidence 0.23 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.25 Pain Relevance 0
Pes may serve as a reasonable estimate for Ppl and Ppc, but is one step removed from these values and may underestimate increases in either Ppl or Ppc when lung volumes also increase [10].
Positive_regulation (increases) of Ppl in lung
6) Confidence 0.20 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.24 Pain Relevance 0
Thus, estimates of Ppc made by using Ppl (Pes) measurements may overestimate surrounding pressure as Ppl is increasing.
Positive_regulation (increasing) of Ppl
7) Confidence 0.15 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.08 Pain Relevance 0
Changes in Ppl induced by positive-pressure ventilation are not the same in all regions of the thorax; Ppl at the diaphragm increases least, and juxtacardiac Ppl increases most [12].
Positive_regulation (increases) of Ppl in diaphragm
8) Confidence 0.15 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.24 Pain Relevance 0
Changes in Ppl induced by positive-pressure ventilation are not the same in all regions of the thorax; Ppl at the diaphragm increases least, and juxtacardiac Ppl increases most [12].
Positive_regulation (induced) of Ppl in diaphragm
9) Confidence 0.13 Published 2005 Journal Crit Care Section Body Doc Link PMC1414045 Disease Relevance 0.24 Pain Relevance 0

General Comments

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