INT111195

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.20
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
RVLM 10
brainstem 2
heart 2
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 42 99.70 Very High Very High Very High
medulla 25 99.68 Very High Very High Very High
gABA 14 97.72 Very High Very High Very High
depression 13 96.64 Very High Very High Very High
anesthesia 7 91.04 High High
Glutamate 9 60.52 Quite High
antagonist 2 38.48 Quite Low
Bioavailability 2 26.00 Quite Low
ketamine 3 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 37 98.88 Very High Very High Very High
Endotoxemia 18 97.92 Very High Very High Very High
Cardiovascular Disorder Under Development 12 96.64 Very High Very High Very High
Heart Rate Under Development 6 94.56 High High
Pressure Volume 2 Under Development 7 93.92 High High
Stress 11 77.60 Quite High
Depression 1 58.24 Quite High
Pressure And Volume Under Development 14 50.00 Quite Low
Hypertension 6 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that a downregulation of molecular synthesis and functional expression of AT1R in the ventrolateral medulla is consequential to the overproduction of NO through upregulation of iNOS in the RVLM and may underlie the cardiovascular depression that takes place during experimental endotoxemia.
Negative_regulation (downregulation) of Gene_expression (expression) of AT1R in medulla associated with medulla, endotoxemia, rostral ventrolateral medulla, depression and cardiovascular disorder under development
1) Confidence 0.58 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.52 Pain Relevance 0.48
Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R.
Negative_regulation (reversed) of Gene_expression (synthesis) of AT1R in RVLM associated with rostral ventrolateral medulla
2) Confidence 0.58 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.34 Pain Relevance 0.53
Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R.
Negative_regulation (reduction) of Gene_expression (synthesis) of AT1R in RVLM associated with rostral ventrolateral medulla
3) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.34 Pain Relevance 0.50
This was followed by a significant downregulation of both mRNA and protein levels of AT1R in the ventrolateral medulla, alongside reduced efficacy of angiotensin II (50 pmol) to induce an increase in systemic arterial pressure, heart rate, or sympathetic vasomotor outflow on unilateral microinjection into the RVLM.
Negative_regulation (downregulation) of Gene_expression (levels) of AT1R in heart associated with medulla and rostral ventrolateral medulla
4) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.48
The current study evaluated the hypothesis that a downregulation of the molecular synthesis and functional expression of angiotensin subtype 1 receptor (AT1R) in the RVLM is consequential to this upregulated iNOS.
Negative_regulation (downregulation) of Gene_expression (expression) of AT1R in RVLM associated with rostral ventrolateral medulla
5) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.38
The current study evaluated the hypothesis that a downregulation of the molecular synthesis and functional expression of angiotensin subtype 1 receptor (AT1R) in the RVLM is consequential to this upregulated iNOS.
Negative_regulation (downregulation) of Gene_expression (expression) of angiotensin subtype 1 receptor in RVLM associated with rostral ventrolateral medulla
6) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.41 Pain Relevance 0.38
In the present study, we found a reduction in the mRNA AT1 expression in the brainstem tissue in CRF rats accompanied by a significant increase in the level of p47phox and gp91phox gene expression in the RVLM compared to C group.
Negative_regulation (reduction) of Gene_expression (expression) of AT1 in brainstem associated with medulla and chronic renal failure
7) Confidence 0.28 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.76 Pain Relevance 0.43

General Comments

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