INT111196

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
plasma 2
RVLM 2
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 7 99.70 Very High Very High Very High
medulla 3 90.88 High High
depression 2 80.48 Quite High
agonist 103 75.44 Quite High
anesthesia 1 68.24 Quite High
adenocard 60 55.84 Quite High
antagonist 17 52.24 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 4 95.60 Very High Very High Very High
Heart Rate Under Development 1 77.88 Quite High
Pressure Volume 2 Under Development 1 77.24 Quite High
Endotoxemia 3 75.00 Quite High
Cardiovascular Disorder Under Development 2 55.72 Quite High
Hypoxia 5 53.92 Quite High
Cancer 11 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R.
Negative_regulation (reversed) of Negative_regulation (reduction) of AT1R in RVLM associated with rostral ventrolateral medulla
1) Confidence 0.42 Published 2003 Journal Hypertension Section Abstract Doc Link 12810755 Disease Relevance 0.34 Pain Relevance 0.53
This loss of response was accompanied by a significant decrease in both total numbers of A1R and proteins in synaptic plasma membranes in the brain, paralleling the finding by Stiles and co-workers in adipocytes [44].
Negative_regulation (decrease) of Negative_regulation (numbers) of A1R in plasma associated with obesity
2) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.15 Pain Relevance 0.13

General Comments

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