INT111198

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.54
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Fasn) lyase activity (Fasn) oxidoreductase activity (Fasn)
Golgi apparatus (Fasn) biosynthetic process (Fasn) plasma membrane (Fasn)
Anatomy Link Frequency
hepatocytes 2
fat 2
lipid droplets 1
apoptotic cells 1
adipocytes 1
Fasn (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 99.74 Very High Very High Very High
agonist 10 83.04 Quite High
Central nervous system 2 72.40 Quite High
Dismenorea 1 57.36 Quite High
Pain 1 55.32 Quite High
Inflammation 18 50.00 Quite Low
Paracetamol 7 50.00 Quite Low
melanocortin 1 receptor 11 43.88 Quite Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 58 97.40 Very High Very High Very High
Diabetes Mellitus 14 97.30 Very High Very High Very High
Targeted Disruption 87 93.92 High High
Hyperlipidemia 3 91.56 High High
Hyperinsulinism 8 90.80 High High
Body Weight 16 87.80 High High
Syndrome 7 86.40 High High
Injury 7 83.96 Quite High
Hyperglycemia 5 75.00 Quite High
Hyperplasia 7 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hepatocyte apoptosis was analyzed by flow cytometer and the expression level of Fas mRNA was determined by RT-PCR.
Gene_expression (expression) of Fas mRNA in hepatocyte
1) Confidence 0.55 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.
Gene_expression (expression) of Fas mRNA in apoptotic cells
2) Confidence 0.55 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: sHSS protected hepatocytes from AAP-induced injury, which might be associated with its protection of the mitochondria and inhibition of apoptosis and expression of Fas mRNA in hepatocytes.


Gene_expression (expression) of Fas mRNA in hepatocytes
3) Confidence 0.55 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.06 Pain Relevance 0
EA exerted beneficial effects on glucose and lipid homeostasis in diabetes that are not secondary to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBPla, FAS, GAPT) and PPAR-gamma gene expression in periepididymal fat.
Gene_expression (expression) of FAS in fat associated with diabetes mellitus
4) Confidence 0.33 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 16095853 Disease Relevance 0.69 Pain Relevance 0.11
Differential expression of fatty acid synthase genes, Acl, Fat and Kas, in Capsicum fruit.
Gene_expression (expression) of fatty acid synthase in Fat associated with qutenza
5) Confidence 0.27 Published 2003 Journal J. Exp. Bot. Section Title Doc Link 12810854 Disease Relevance 0 Pain Relevance 0.10
Additionally, recombinant agouti protein causes an increase in fatty acid synthase expression and activity, and the accumulation of triglycerides in cultured adipocytes [37].
Gene_expression (expression) of fatty acid synthase in adipocytes associated with obesity
6) Confidence 0.18 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.24 Pain Relevance 0.04
SREBP-1c regulates the expression of constellations of glycolytic and lipogenic genes, including stearoyl CoA desaturase (Scd-1) and fatty acid synthase (Fas) [Hebbachi et al., 2008; Horton et al., 2002; Reddy and Rao, 2006].
Gene_expression (expression) of fatty acid synthase
7) Confidence 0.14 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.06 Pain Relevance 0
Adipogenesis in stimulated 3T3-L1-preadipocytes was determined by oil red O-staining of intracellular lipid droplets, triglyceride levels, expression of peroxisome proliferator-activated receptor-gamma, and expression of fatty acid synthase.
Gene_expression (expression) of fatty acid synthase in lipid droplets
8) Confidence 0.14 Published 2007 Journal Circ. Res. Section Abstract Doc Link 17347480 Disease Relevance 0.34 Pain Relevance 0.27

General Comments

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