INT111208

Context Info Confidence 0.49 First Reported 2003 Last Reported 2007 Negated 0 Speculated 2 Reported most in Abstract Documents 2 Total Number 4 Disease Relevance 0.17 Pain Relevance 1.46

endoplasmic reticulum (UGT2B7) lipid metabolic process (UGT2B7)

Anatomy Link Frequency 2B7 2 macula densa 1 kidney 1 UGT2B7 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 3 100.00 Patient controlled alalgesia 1 98.84 Morphine 15 98.76 Cancer pain 1 96.60 Opioid 1 96.44 Analgesic 1 94.80 medulla 6 90.00 cINOD 2 25.00

Disease Link Frequency Relevance Heat Cancer Pain 1 96.60 Cancer 1 75.00 INFLAMMATION 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We investigated the variation in the uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) gene in patients receiving patient-controlled analgesia with morphine.

Spec (investigated) Positive_regulation (variation) of UGT2B7 in 2B7 associated with patient controlled alalgesia and morphine

1) Confidence 0.49 Published 2003 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 12811366 Disease Relevance 0 Pain Relevance 0.62

This study evaluated genetic variation in the mu-opioid receptor, betaarrestin2, stat6 and uridine diphosphate-glucuronysltransferase 2B7 (UGT2B7) genes, in patients who responded to morphine vs those who were switched to alternative opioids.

Positive_regulation (variation) of UGT2B7 in 2B7 associated with opioid receptor, opioid and morphine

2) Confidence 0.49 Published 2005 Journal Pharmacogenomics J. Section Abstract Doc Link 16103897 Disease Relevance 0.17 Pain Relevance 0.73

Additionally, UGT1A and UGT2B7 expression was demonstrated in the macula densa, supporting a potential role of UGTs in regulating aldosterone.

Positive_regulation (demonstrated) of UGT2B7 in macula densa

3) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17698974 Disease Relevance 0 Pain Relevance 0.07

Using human kidney sections and human kidney cortical microsomes (HKCM) and human kidney medullary microsomes (HKMM), we combined immunohistochemistry to investigate UGT1A and UGT2B7 expression with in vitro microsomal studies to determine the kinetics of S-naproxen acyl glucuronidation.

Spec (investigate) Positive_regulation (investigate) of UGT2B7 in kidney

4) Confidence 0.22 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17698974 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.