INT11121

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2008
Negated 2
Speculated 2
Reported most in Abstract
Documents 64
Total Number 74
Disease Relevance 34.09
Pain Relevance 11.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 41
heart 5
blood 2
brain 2
atrial wall 1
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 30 100.00 Very High Very High Very High
noradrenaline 17 100.00 Very High Very High Very High
Morphine 7 99.98 Very High Very High Very High
bradykinin 4 99.92 Very High Very High Very High
Clonidine 45 99.84 Very High Very High Very High
cva 25 99.72 Very High Very High Very High
narcan 24 99.70 Very High Very High Very High
Angina 25 99.68 Very High Very High Very High
alcohol 18 98.96 Very High Very High Very High
diabetic neuropathy 3 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 234 100.00 Very High Very High Very High
Heart Rate Under Development 122 99.84 Very High Very High Very High
Coronary Artery Disease 12 99.82 Very High Very High Very High
Cv General 4 Under Development 18 99.72 Very High Very High Very High
Cv General 3 Under Development 12 99.68 Very High Very High Very High
Angina 8 99.60 Very High Very High Very High
Myocardial Infarction 40 99.58 Very High Very High Very High
Cv General 2 Under Development 276 99.28 Very High Very High Very High
Pulmonary Hypertension 42 99.28 Very High Very High Very High
Body Weight 10 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Volume loading increased plasma ANF levels by about 40% in the control and 30% in the dihydralazine treated group, whereas plasma ANF remained unchanged by volume loading in the clonidine-treated group.
Positive_regulation (increased) of ANF in plasma associated with clonidine
1) Confidence 0.70 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455172 Disease Relevance 0.08 Pain Relevance 0.54
Acute volume loading increases plasma atrial natriuretic factor (ANF) levels in man and animals.
Positive_regulation (increases) of ANF in plasma associated with natriuresis
2) Confidence 0.70 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455172 Disease Relevance 0.10 Pain Relevance 0.24
Volume loading increased plasma ANF levels by 30-40% of base-line values in the control and the dihydralazine groups and by 15% in the clonidine group.
Positive_regulation (increased) of ANF in plasma associated with clonidine
3) Confidence 0.69 Published 1989 Journal J. Appl. Physiol. Section Abstract Doc Link 2551880 Disease Relevance 0.16 Pain Relevance 0.49
It was the objective of the present study to test the hypothesis that acute administration of low doses of ETOH would increase the plasma content of atrial natriuretic peptide (ANP), a hormone known to decrease blood pressure.
Positive_regulation (increase) of ANP in blood associated with natriuresis
4) Confidence 0.69 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.27 Pain Relevance 0.10
The magnitudes of increased ANF and decreased Vas were correlated with the decreased MBP (r = -0.57 and 0.53, respectively, P < 0.05).
Positive_regulation (increased) of ANF
5) Confidence 0.68 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 7901963 Disease Relevance 0.25 Pain Relevance 0.42
In the MI group, plasma ANF levels significantly increased at the 75-watt workload and significantly decreased at 10 minutes after exercise, whereas in the control group, the increase in plasma ANP levels after a 75-watt workload, compared with those at rest, was not significant.
Positive_regulation (increase) of ANP in plasma associated with myocardial infarction
6) Confidence 0.67 Published 1988 Journal Am. Heart J. Section Abstract Doc Link 2965499 Disease Relevance 0.64 Pain Relevance 0.08
Two patients with very high circulating NA levels due to phaeochromocytoma, but receiving alpha- and beta-blockade, did not have clearly elevated ANP.
Neg (not) Positive_regulation (elevated) of ANP associated with noradrenaline and pheochromocytoma
7) Confidence 0.66 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2959419 Disease Relevance 0.52 Pain Relevance 0.39
Compared with it in control subjects, plasma ANP concentrations before closure were significantly elevated.
Positive_regulation (elevated) of plasma ANP in plasma
8) Confidence 0.63 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.61 Pain Relevance 0
Increased ANP concentrations in patients with ASD correlated positively with PAP may play an important role in protecting the pulmonary bed.
Positive_regulation (Increased) of ANP associated with cv general 2 under development
9) Confidence 0.63 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.86 Pain Relevance 0
ANP availability is increased in heart failure.
Positive_regulation (increased) of ANP in heart associated with heart rate under development
10) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 1.05 Pain Relevance 0
Our findings may also be important in terms of human pathophysiology, both in conditions associated with increased ANP and with decreased ANP availability.
Positive_regulation (increased) of ANP
11) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.96 Pain Relevance 0
During MAT, low responders showed significantly (p < 0.01) increased plasma levels of beta-endorphin, cortisol, catecholamines, and atrial natriuretic factor (ANF) and decreased levels of endothelin-1, whereas high responders showed increased (p < 0.01) levels of Metenkephalin, dynorphin B, and catecholamines.
Positive_regulation (increased) of ANF in plasma associated with natriuresis, dynorphin and catecholamine
12) Confidence 0.62 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.41
Acute volume loading increases plasma atrial natriuretic factor (ANF) levels in man and animals.
Positive_regulation (increases) of atrial natriuretic factor in plasma associated with natriuresis
13) Confidence 0.61 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455172 Disease Relevance 0.10 Pain Relevance 0.23
We also confirm the increased plasma ANP concentration observed in patients with congestive cardiac failure and renal failure.
Positive_regulation (increased) of plasma ANP in plasma associated with heart rate under development and renal failure
14) Confidence 0.61 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2957125 Disease Relevance 0.80 Pain Relevance 0.14
It was been shown that physical exercise increases plasma atrial natriuretic peptide (ANP) level.
Positive_regulation (increases) of ANP in plasma associated with natriuresis
15) Confidence 0.61 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.17 Pain Relevance 0.39
Plasma ANP levels were increased significantly within 15 min after the i.p. injection of 1 or 2 g of ETOH/kg b.wt.
Positive_regulation (increased) of Plasma ANP in Plasma
16) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.26 Pain Relevance 0.10
This increase in plasma ANP level was associated with a rapid decrease of atrial ANP, but not of ventricular ANP which on the contrary was significantly elevated at 120 min postinjection.
Positive_regulation (increase) of plasma ANP in plasma
17) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.24 Pain Relevance 0.12
It was the objective of the present study to test the hypothesis that acute administration of low doses of ETOH would increase the plasma content of atrial natriuretic peptide (ANP), a hormone known to decrease blood pressure.
Positive_regulation (increase) of natriuretic peptide in blood associated with natriuresis
18) Confidence 0.60 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.27 Pain Relevance 0.10
A dramatic increase of rat plasma immunoreactive atriopeptin induced by clonidine (iv) was partly antagonised by pretreatment with naloxone (4mg/kg) or phentolamine (10mg/kg).
Positive_regulation (induced) of atriopeptin in plasma associated with narcan and clonidine
19) Confidence 0.60 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2571190 Disease Relevance 0 Pain Relevance 0.66
A dramatic increase of rat plasma immunoreactive atriopeptin induced by clonidine (iv) was partly antagonised by pretreatment with naloxone (4mg/kg) or phentolamine (10mg/kg).
Positive_regulation (increase) of atriopeptin in plasma associated with narcan and clonidine
20) Confidence 0.60 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2571190 Disease Relevance 0 Pain Relevance 0.66

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