INT111223

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 47
Total Number 56
Disease Relevance 39.14
Pain Relevance 10.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
endothelial cells 5
immune system 2
neuronal 1
blood vessel 1
monocytes 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.84 Very High Very High Very High
Calcitonin gene-related peptide 1 99.82 Very High Very High Very High
cytokine 227 99.72 Very High Very High Very High
rheumatoid arthritis 47 99.60 Very High Very High Very High
Inflammation 564 99.40 Very High Very High Very High
Morphine 36 99.32 Very High Very High Very High
ischemia 22 99.32 Very High Very High Very High
antagonist 29 99.12 Very High Very High Very High
cva 32 99.08 Very High Very High Very High
cOX1 7 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 19 100.00 Very High Very High Very High
Stress 210 99.92 Very High Very High Very High
Atherosclerosis 44 99.84 Very High Very High Very High
Graft Vs Host Disease 2 99.84 Very High Very High Very High
Cv General 4 Under Development 12 99.68 Very High Very High Very High
Aneurism 8 99.64 Very High Very High Very High
Rheumatoid Arthritis 47 99.60 Very High Very High Very High
Parkinson's Disease 12 99.46 Very High Very High Very High
INFLAMMATION 618 99.40 Very High Very High Very High
Autoimmune Disease 22 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treating endothelial cells with AZD3582 at concentrations that were effective at inducing HO-1 also reduced NADPH-dependent production of oxygen radicals.
Positive_regulation (inducing) of HO-1 in endothelial cells
1) Confidence 0.70 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15911218 Disease Relevance 0.07 Pain Relevance 0.17
Beyond gastric acid reduction: proton pump inhibitors induce heme oxygenase-1 in gastric and endothelial cells.
Positive_regulation (induce) of heme oxygenase-1 in endothelial cells associated with cox1
2) Confidence 0.70 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 16712795 Disease Relevance 0.18 Pain Relevance 0.11
HO-1 induction might account for the gastroprotective effects of PPIs independently of acid inhibition, especially in NSAID gastropathy.
Positive_regulation (induction) of HO-1 associated with cinod
3) Confidence 0.70 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.15 Pain Relevance 0.10
This led us to the hypothesis that celecoxib induces the vasculoprotective enzyme heme oxygenase-1 (HO-1).
Positive_regulation (induces) of HO-1
4) Confidence 0.69 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.44 Pain Relevance 0.37
This led us to the hypothesis that celecoxib induces the vasculoprotective enzyme heme oxygenase-1 (HO-1).
Positive_regulation (induces) of heme oxygenase-1
5) Confidence 0.69 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.44 Pain Relevance 0.37
HO-1 induction provides a molecular mechanism for clinical observations indicating relative freedom from atherothrombotic complications in patients taking celecoxib compared to other NSAIDs with comparable anti-inflammatory activity.
Positive_regulation (induction) of HO-1 associated with inflammation and cinod
6) Confidence 0.69 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.23 Pain Relevance 0.27
In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity.
Positive_regulation (increased) of HO-1 in endothelial cells
7) Confidence 0.69 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.41 Pain Relevance 0.35
HO-1 is also induced in atherosclerotic lesions of human and experimental animals, and has a protective role in the blood vessel wall during atherogenesis [15,16].
Positive_regulation (induced) of HO-1 in blood vessel associated with atherosclerosis
8) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.73 Pain Relevance 0.18
S genotype in the HO-1 gene promoter may increase the induction of HO-1 by reactive oxygen species in patients with low HDL-C concentrations.
Positive_regulation (induction) of HO-1 associated with disorder of lipid metabolism
9) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.20 Pain Relevance 0.04
Hemin, an inducer of heme oxygenase (HO) activity, inhibited GEC proliferation and promoted GEC apoptosis under basal and morphine-stimulated conditions.
Positive_regulation (inducer) of HO in GEC associated with apoptosis and morphine
10) Confidence 0.61 Published 2003 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 12812915 Disease Relevance 1.03 Pain Relevance 1.17
Thus, the ability to activate HO-1 induction and associated antioxidant pathways apparently distinguishes PETN from other long-acting nitrates and may explain their different patterns of action in vivo (Figure 9).
Positive_regulation (induction) of HO-1
11) Confidence 0.61 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.19 Pain Relevance 0.04
Expression of cyclooxygenase isoforms 1 and 2 remained unaffected, and COX-inhibitors did not antagonize HO-1 induction by PPIs.
Neg (not) Positive_regulation (induction) of HO-1
12) Confidence 0.61 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.17 Pain Relevance 0.08
Carbacyclin, an agonist of IP, induced HO-1.
Positive_regulation (induced) of HO-1 associated with agonist
13) Confidence 0.60 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.89 Pain Relevance 0.36
The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.
Positive_regulation (induction) of HO-1 associated with stress, aspirin, inflammation and antagonist
14) Confidence 0.60 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 1.06 Pain Relevance 0.21
We have addressed whether the induction of COX-2-dependent prostanoids in endothelial cells by LSS plays a role in restraining endothelial tumor necrosis factor (TNF)-alpha generation, a proatherogenic cytokine, through the induction of heme oxygenase-1 (HO)-1, an antioxidant enzyme.
Spec (whether) Positive_regulation (induction) of heme oxygenase-1 in endothelial cells associated with stress, necrosis, cancer and cytokine
15) Confidence 0.60 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.88 Pain Relevance 0.05
Coincident induction of HO-1 was detected.
Positive_regulation (induction) of HO-1
16) Confidence 0.60 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 1.00 Pain Relevance 0.19
In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity.
Positive_regulation (induced) of HO-1 in endothelial cells
17) Confidence 0.50 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.41 Pain Relevance 0.35
Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.
Positive_regulation (enhance) of heme oxygenase-1 in vascular endothelium associated with inflammation
18) Confidence 0.50 Published 2010 Journal Free Radic. Biol. Med. Section Title Doc Link 20083195 Disease Relevance 0.47 Pain Relevance 0.41
S genotype in the HO-1 gene promoter may increase the induction of HO-1 by reactive oxygen species in patients with low HDL-C concentrations.
Spec (may) Positive_regulation (increase) of HO-1 gene associated with disorder of lipid metabolism
19) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.20 Pain Relevance 0.04
Furthermore, celecoxib-induced HO-1 was inhibited by dominant-negative Nrf2.
Positive_regulation (induced) of HO-1
20) Confidence 0.46 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.32 Pain Relevance 0.43

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