INT111230

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.72
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
lymphocytes 1
nucleus 1
T-cell 1
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 98.90 Very High Very High Very High
cINOD 10 76.80 Quite High
aspirin 13 75.00 Quite High
antagonist 10 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 99.40 Very High Very High Very High
Malignant Neoplastic Disease 9 99.24 Very High Very High Very High
Chronic Lymphoid Leukemia 152 98.14 Very High Very High Very High
Colon Cancer 14 95.28 Very High Very High Very High
Disease 9 82.48 Quite High
INFLAMMATION 4 75.36 Quite High
Apoptosis 47 70.40 Quite High
Stress 11 65.40 Quite High
Mouth Cancer 1 52.92 Quite High
Toxicity 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin translocation from the cytosol into the nucleus, increasing Tcf4/Lef1 transcriptional activity and promoting tumor cell invasion. ?
Transcription (activity) of Lef1 in nucleus associated with cancer
1) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
This result suggests that EA may inhibit LEF-1-mediated transcription through destabilization of the LEF-1/?
Transcription (transcription) of LEF-1-mediated
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.32 Pain Relevance 0
Importantly, EA exhibited selective cytotoxicity towards primary CLL cells, possibly due to the dependence of the malignant lymphocytes on proteins regulated by LEF-1 transcription.


Transcription (transcription) of LEF in lymphocytes associated with chronic lymphoid leukemia, addiction and malignant neoplastic disease
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.93 Pain Relevance 0.05
A key output in this pathway is the nuclear level of beta-catenin, which determines the transcription of T-cell transcription factor (TCF)/lymphoid enhancer-binding factor-responsive target genes.
Spec (determines) Transcription (transcription) of lymphoid enhancer-binding factor-responsive in T-cell
4) Confidence 0.02 Published 2003 Journal Mol. Cancer Ther. Section Abstract Doc Link 12813129 Disease Relevance 0.20 Pain Relevance 0.28

General Comments

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