INT111237

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.07
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Dnajb1) protein folding (Dnajb1) nucleus (Dnajb1)
response to stress (Dnajb1) cytoplasm (Dnajb1)
Anatomy Link Frequency
fibroblasts 1
reticulum 1
Dnajb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1 97.84 Very High Very High Very High
anesthesia 1 72.00 Quite High
cva 1 70.00 Quite High
Calcium channel 14 36.88 Quite Low
Central nervous system 14 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 5 100.00 Very High Very High Very High
Apoptosis 6 97.12 Very High Very High Very High
Hemorrhagic Shock 5 84.40 Quite High
Hemorrhage 1 70.00 Quite High
Toxicity 2 67.84 Quite High
Lysosomal Storage Diseases 48 50.00 Quite Low
Gauchers Disease 22 5.00 Very Low Very Low Very Low
Mucopolysaccharidoses 22 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Neuropathic Pain 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Caspase-3 activation, heat shock protein (HSP) 70, and HSP40 were assessed by western blotting.
Positive_regulation (activation) of HSP40 associated with shock
1) Confidence 0.31 Published 2003 Journal Shock Section Abstract Doc Link 12813364 Disease Relevance 0.73 Pain Relevance 0.11
Specifically, cytosolic HSP25, HSP40, HSP70, HSP105 and microsomal HSP32 (HO-1) were strongly upregulated within the first few hours of TFEC treatment, while little change was observed among other HSPs that are predominantly localized in the mitochondria and endoplasmic reticulum (ER).
Positive_regulation (upregulated) of HSP40 in reticulum
2) Confidence 0.26 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16678137 Disease Relevance 0.34 Pain Relevance 0.10
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Positive_regulation (increased) of Hsp40
3) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
A strictly analogous RT-PCR analysis of N370S/V394L GC fibroblasts reveals similarly increased mRNA expression levels of Hsp40, however BiP and Hsp90 exhibit less of an increase after 7 d of diltiazem treatment (Figure S5).
Positive_regulation (increased) of Hsp40 in fibroblasts
4) Confidence 0.07 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

General Comments

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