INT111255

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnb5) plasma membrane (Gnb5) nucleus (Gnb5)
signal transducer activity (Gnb5)
Anatomy Link Frequency
lymph node 1
gray matter 1
Gnb5 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 11 99.68 Very High Very High Very High
Thalamus 3 97.52 Very High Very High Very High
Central grey 1 97.12 Very High Very High Very High
Delta opioid receptors 2 95.24 Very High Very High Very High
Opioid 5 85.48 High High
Analgesic 2 81.40 Quite High
tolerance 7 80.72 Quite High
Intracerebroventricular 2 78.24 Quite High
Potency 1 72.32 Quite High
Inflammation 6 72.20 Quite High
Disease Link Frequency Relevance Heat
Syndrome 22 100.00 Very High Very High Very High
Lymph Node Tuberculosis 6 99.88 Very High Very High Very High
Urological Neuroanatomy 4 97.12 Very High Very High Very High
Mycobacterial Infection 16 94.64 High High
Inflammatory Bowel Disease 22 92.64 High High
Neuropathic Pain 1 87.00 High High
Alcohol Addiction 1 86.16 High High
Appetite Loss 1 85.68 High High
Infection 5 82.20 Quite High
Neuropathy 7 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This paper reports the presence of the Gbeta5 protein and its mRNA in all areas of mouse CNS, and also its involvement in the cellular signals initiated at mu- and delta-opioid receptors.
Transcription (presence) of Gbeta5 associated with delta opioid receptors
1) Confidence 0.66 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814661 Disease Relevance 0.08 Pain Relevance 0.48
At 2 days after commencing sustained morphine treatment, the levels of mRNA for RGS7, RGS9-2, RGS11, and Gbeta5 increased in most of the brain structures studied (striatum, thalamus, periaqueductal gray matter (PAG), and cortex).
Transcription (levels) of Gbeta5 in gray matter associated with urological neuroanatomy, thalamus, central grey and morphine
2) Confidence 0.45 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.35 Pain Relevance 1.08
The patient was diagnosed with lymph node tuberculosis (LNT) and suffered GBS early after treatment onset.
Transcription (suffered) of GBS in lymph node associated with syndrome and lymph node tuberculosis
3) Confidence 0.25 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2912254 Disease Relevance 2.39 Pain Relevance 0.10

General Comments

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