INT111258

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.81
Pain Relevance 8.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rgs9) nucleus (Rgs9) cytoplasm (Rgs9)
signal transducer activity (Rgs9)
Anatomy Link Frequency
neuronal 1
PAG 1
thalamus 1
neural 1
Rgs9 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 25 100.00 Very High Very High Very High
Opioid 21 99.74 Very High Very High Very High
Thalamus 6 99.68 Very High Very High Very High
Delta opioid receptors 6 99.42 Very High Very High Very High
Morphine 48 99.24 Very High Very High Very High
mu opioid receptor 18 99.10 Very High Very High Very High
Analgesic 11 98.32 Very High Very High Very High
Central grey 8 98.20 Very High Very High Very High
Dopamine 2 97.68 Very High Very High Very High
opioid receptor 14 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.96 Very High Very High Very High
Urological Neuroanatomy 28 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, doses of the opioid able to induce tolerance promoted the stable transfer of Galpha subunits to the RGS9-2 control.
Regulation (control) of RGS9-2 associated with tolerance and opioid
1) Confidence 0.54 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.28 Pain Relevance 0.98
ED(80) analgesic dose of morphine gave rise to acute tolerance in control mice, but did not promote tolerance in RGS6, RGS7, RGS9-2, or RGS11 knockdown animals.
Regulation (tolerance) of RGS9-2 associated with analgesic, tolerance and morphine
2) Confidence 0.35 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12902995 Disease Relevance 0 Pain Relevance 1.52
In these morphine tolerant-dependent mice, the greater changes were found for RGS9-2 in the thalamus (>500%) and PAG (>200%).
Regulation (changes) of RGS9-2 in thalamus associated with urological neuroanatomy, thalamus and morphine
3) Confidence 0.34 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.38 Pain Relevance 1.24
In pull-down assays performed on membranes from mouse periaqueductal gray matter (PAG), mu-opioid receptors co-precipitated with delta-opioid receptors, Gi/o/z/q proteins, and the regulators of G-protein signalling RGS4, RGS9-2, RGS14, RGSZ1 and RGSZ2.
Regulation (regulators) of RGS9-2 in PAG associated with mu opioid receptor, urological neuroanatomy, delta opioid receptors and central grey
4) Confidence 0.30 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.36 Pain Relevance 0.64
ED80 analgesic dose of morphine gave rise to acute tolerance in control mice, but did not promote tolerance in Gbeta5 or RGS9-2 knock-down animals.
Regulation (tolerance) of RGS9-2 associated with targeted disruption, analgesic, tolerance and morphine
5) Confidence 0.24 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814661 Disease Relevance 0.18 Pain Relevance 1.37
Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization.
Regulation (regulator) of RGS9-2 associated with mu opioid receptor
6) Confidence 0.24 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 15632124 Disease Relevance 0.25 Pain Relevance 0.72
Members of the R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11) are found in the mouse CNS.
Regulation (regulators) of RGS9-2
7) Confidence 0.21 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12902995 Disease Relevance 0 Pain Relevance 0.53
The R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11), and its binding protein Gbeta5, are found in neural structures of mouse brain.
Regulation (regulators) of RGS9-2 in neural
8) Confidence 0.20 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0 Pain Relevance 0.58
The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2.
Neg (no) Regulation (change) of RGS9-2 associated with opioid
9) Confidence 0.18 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.34 Pain Relevance 0.99
A member of regulator of G-protein signaling family, RGS9-2, is an essential modulator of signaling through neuronal dopamine and opioid G-protein-coupled receptors.
Regulation (regulator) of RGS9-2 in neuronal associated with dopamine and opioid
10) Confidence 0.16 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18094251 Disease Relevance 0 Pain Relevance 0.15
These findings indicate that treatment strategies targeting RGS9-2 levels or activity might be used to enhance responses to drugs acting at GPCRs and/or prevent undesired drug actions.
Regulation (targeting) of RGS9-2
11) Confidence 0.08 Published 2009 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 19211160 Disease Relevance 0 Pain Relevance 0.18

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