INT111264

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 1.96
Pain Relevance 10.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rgs9) nucleus (Rgs9) cytoplasm (Rgs9)
signal transducer activity (Rgs9)
Anatomy Link Frequency
brain 1
synapses 1
Rgs9 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 147 100.00 Very High Very High Very High
Opioid 74 99.98 Very High Very High Very High
mu opioid receptor 40 99.98 Very High Very High Very High
Morphine 184 99.82 Very High Very High Very High
Delta opioid receptors 4 99.76 Very High Very High Very High
opiate 6 99.60 Very High Very High Very High
analgesia 27 99.04 Very High Very High Very High
tolerance 112 98.88 Very High Very High Very High
Antinociceptive 14 98.48 Very High Very High Very High
Analgesic 80 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 2 99.06 Very High Very High Very High
Urological Neuroanatomy 50 98.20 Very High Very High Very High
Targeted Disruption 5 89.92 High High
Sprains And Strains 2 75.04 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we report an identification of molecular chaperone Hsc70 (Heat shock cognate protein 70) as a critical mediator of RGS9-2 expression that is specifically recruited to the intrinsically disordered C-terminal domain of RGS9-2 following its dissociation from R7BP.
Gene_expression (expression) of RGS9-2 associated with shock
1) Confidence 0.76 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20095651 Disease Relevance 0.25 Pain Relevance 0.16
Changes in RGS9-2 expression are observed in response to a number of signaling events and are thought to contribute to the plasticity of the neurotransmitter action.
Gene_expression (expression) of RGS9-2 associated with neurotransmitter
2) Confidence 0.76 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20095651 Disease Relevance 0.19 Pain Relevance 0.18
We also show that over-expression of RGS9-2 prevents opiate-induced extracellular signal-regulated kinase phosphorylation.
Gene_expression (over-expression) of RGS9-2 associated with opiate
3) Confidence 0.75 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725581 Disease Relevance 0 Pain Relevance 1.00
The in vivo knockdown of RGS9-2 expression prevented morphine from altering the association between MORs and G-proteins, and tolerance did not develop.
Gene_expression (expression) of RGS9-2 associated with tolerance and morphine
4) Confidence 0.68 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.28 Pain Relevance 1.19
This multistep process is initiated by the morphine-induced transfer of MOR-associated Galpha subunits to the RGS9-2 proteins, followed by Ser phosphorylation of the latter and their binding to 14-3-3 proteins.
Gene_expression (transfer) of RGS9-2 associated with opioid receptor and morphine
5) Confidence 0.68 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.16 Pain Relevance 1.01
We have previously demonstrated that mice lacking the RGS9 gene show enhanced morphine analgesia and delayed development of tolerance.
Neg (lacking) Gene_expression (lacking) of RGS9 gene associated with tolerance, analgesia and morphine
6) Confidence 0.65 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725581 Disease Relevance 0 Pain Relevance 0.60
Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization.
Gene_expression (transfers) of RGS9-2 associated with mu opioid receptor
7) Confidence 0.59 Published 2005 Journal J. Biol. Chem. Section Title Doc Link 15632124 Disease Relevance 0.25 Pain Relevance 0.72
The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2.
Neg (no) Gene_expression (produced) of RGS9-2 associated with opioid
8) Confidence 0.52 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.35 Pain Relevance 0.99
The R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11), and its binding protein Gbeta5, are found in neural structures of mouse brain.
Gene_expression (found) of RGS9-2 in brain
9) Confidence 0.50 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0 Pain Relevance 0.67
Nevertheless, the absence of RGS9 did not affect the activity of WIN55,212-2 or its capacity to produce CB1R desensitization.
Neg (absence) Gene_expression (absence) of RGS9
10) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.23
Mice with reduced levels of RGS9 proteins display both an increase in the analgesic effects of morphine and a poorer single-dose tolerance.
Gene_expression (levels) of RGS9 associated with analgesic, tolerance and morphine
11) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.08
Implementation of this mechanism throughout ontogenetic development ensures expression of RGS9-2/type 5 G-protein beta subunit/R7BP complexes at postsynaptic sites in unison with increased signaling demands at mature synapses.
Gene_expression (expression) of RGS9-2 in synapses
12) Confidence 0.44 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18094251 Disease Relevance 0 Pain Relevance 0.10
Shielding of these determinants by the binding partner R7 binding-protein (R7BP) controls RGS9-2 expression at the posttranslational level.
Gene_expression (expression) of RGS9-2
13) Confidence 0.44 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18094251 Disease Relevance 0 Pain Relevance 0.12
Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.
Gene_expression (Expression) of RGS9-2
14) Confidence 0.44 Published 2007 Journal J. Neurosci. Section Title Doc Link 18094251 Disease Relevance 0 Pain Relevance 0.14
The expression of Gbeta5 and RGS9-2 proteins (member of the R7 subfamily of RGS) was reduced by blocking their mRNAs with antisense oligodeoxynucleotides (ODN).
Gene_expression (expression) of RGS9-2
15) Confidence 0.42 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814661 Disease Relevance 0.14 Pain Relevance 0.77
The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2.
Gene_expression (levels) of RGS9-2 associated with opioid
16) Confidence 0.40 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15829256 Disease Relevance 0.34 Pain Relevance 0.98

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