INT111272

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
ERPL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 38 99.54 Very High Very High Very High
Morphine 2 80.08 Quite High
Paracetamol 2 63.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BUP utilization by either HLM or P450-transfected cells revealed that another oxidative metabolic pathway exists, which was found to involve CYP 2C9, 2C18, 2C19, and mainly CYP 3A.
Gene_expression (transfected) of HLM associated with buprenorphine
1) Confidence 0.14 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.46
The metabolism of BUP was examined using human liver microsomes (HLM) and Ad293 P450-transfected cell lines, as well as CYP 3A4 and 2C8 recombinant isoforms.
Spec (examined) Gene_expression (transfected) of HLM in liver associated with buprenorphine
2) Confidence 0.11 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.12
The conversion of biochanin A to genistein appears to be mainly mediated by CYP1A2 because of the strong correlation between the conversion rates and CYP1A2 activities in HLM.
Gene_expression (activities) of HLM
3) Confidence 0.09 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12814970 Disease Relevance 0 Pain Relevance 0.06
This study determined the cytochrome P450 (P450) isoforms responsible for metabolism of isoflavones using human liver microsomes (HLM) and expressed P450s.
Gene_expression (expressed) of HLM in liver
4) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12814970 Disease Relevance 0 Pain Relevance 0

General Comments

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