INT111277

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.44
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Anatomy Link Frequency
blood 4
C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 3 100.00 Very High Very High Very High
agonist 3 93.76 High High
antagonist 6 92.80 High High
Pain 33 88.16 High High
Quantitative sensory testing 1 85.00 Quite High
spinal inflammation 23 77.36 Quite High
mu opioid receptor 1 75.00 Quite High
Immobilon 2 74.44 Quite High
Opioid 1 72.72 Quite High
nociceptor 27 70.64 Quite High
Disease Link Frequency Relevance Heat
Disease 29 99.88 Very High Very High Very High
Pressure Volume 2 Under Development 20 99.74 Very High Very High Very High
Increased Venous Pressure Under Development 30 97.60 Very High Very High Very High
Cancer 2 97.56 Very High Very High Very High
Erythema 1 94.08 High High
Nociception 2 93.60 High High
Non-small-cell Lung Cancer 6 92.20 High High
Shock 5 91.04 High High
Burns 2 91.00 High High
Pain 34 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2. the VMR phase, in which there is a strong increase of the O2Hb (and, hence, of the total hemoglobin, that roughly corresponds to the regional cerebral blood volume) while the CO2Hb is kept at a baseline level;
Negative_regulation (level) of Gene_expression (kept) of CO2Hb in blood
1) Confidence 0.42 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.17 Pain Relevance 0.03
Furthermore, the Golgi-disturbing agents brefeldin A and monensin completely blocked naloxone-enhanced expression of i3-1 and C-2 mutants.
Negative_regulation (blocked) of Gene_expression (expression) of C-2 associated with narcan
2) Confidence 0.41 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.43
In two patients, the TC-CO2 electrode had to be repositioned after the initial placement to obtain an effective value.
Negative_regulation (repositioned) of Gene_expression (electrode) of TC-CO2
3) Confidence 0.13 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0.09 Pain Relevance 0
When gastrointestinal blood flow is reduced by restriction of superior mesenteric artery (SMA) blood flow in the absence of the hormonal milieu that occurs with systemic hypovolaemia, mucosal pH decreases (CO2 increases) only when flow is less than 50% of baseline [19].
Negative_regulation (decreases) of Gene_expression (increases) of CO2 in blood associated with pressure volume 2 under development
4) Confidence 0.13 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.37 Pain Relevance 0
Additionally, we observed that in some diseases, the effect of C1 and C2 phenotypes or genotypes seemed to be detectable only in the absence of KIR2DS5 gene but was visible only in its presence in other diseases.
Negative_regulation (effect) of Gene_expression (phenotypes) of C2 associated with disease
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 1.24 Pain Relevance 0.36
One possible link appears to be between the altered phosphorylation of the majority of the signaling molecules at 30 mU/l insulin and above and the decreased expression of MAFbx and possibly the C2 proteasome subunit.
Spec (possibly) Negative_regulation (decreased) of Gene_expression (expression) of C2
6) Confidence 0.11 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.07 Pain Relevance 0
Infrared CO2 lasers (10.6 ?
Negative_regulation (Infrared) of Gene_expression (lasers) of CO2
7) Confidence 0.10 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2991325 Disease Relevance 0.43 Pain Relevance 0.38
On the other hand, the decreased expression of pGL4.71P-C2.1 construct, in which none putative regulatory elements are predicted, prompts us to hypothesize the presence of novel regulatory elements in the C2.1 fragment.
Negative_regulation (decreased) of Gene_expression (expression) of C2
8) Confidence 0.05 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.06 Pain Relevance 0

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