INT111279

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.06
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 6 100.00 Very High Very High Very High
Immobilon 4 99.36 Very High Very High Very High
agonist 4 99.16 Very High Very High Very High
antagonist 12 98.72 Very High Very High Very High
Opioid 2 98.50 Very High Very High Very High
opioid receptor 2 92.00 High High
mu opioid receptor 2 75.00 Quite High
anesthesia 21 70.96 Quite High
positron emission tomography 2 54.00 Quite High
Ultiva 8 46.08 Quite Low
Disease Link Frequency Relevance Heat
Hypercapnia 116 96.76 Very High Very High Very High
Hyperoxia 4 91.52 High High
Shock 10 79.60 Quite High
Pressure Volume 2 Under Development 39 79.20 Quite High
Repression 1 65.96 Quite High
Lactic Acidosis 2 61.56 Quite High
Neuroblastoma 9 28.48 Quite Low
Sepsis 46 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 40 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the Golgi-disturbing agents brefeldin A and monensin completely blocked naloxone-enhanced expression of i3-1 and C-2 mutants.
Positive_regulation (naloxone-enhanced) of Gene_expression (expression) of C-2 associated with narcan
1) Confidence 0.49 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.43
Treatment with the opioid antagonist naloxone, the agonist etorphine, and other hydrophobic ligands enhanced cell surface expression of i3-1 and C-2 mutants.
Positive_regulation (enhanced) of Gene_expression (expression) of C-2 associated with antagonist, agonist, narcan, opioid and immobilon
2) Confidence 0.45 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.41
During TLV, the TC-CO2 value was closer to the actual PaCO2 in 10 patients, the ET-CO2 value was closer in 2 patients and there was no difference in 3 patients (P=NS).
Positive_regulation (closer) of Gene_expression (value) of TC-CO2
3) Confidence 0.16 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0 Pain Relevance 0
It has been suggested that in some cases the Haldane effect may be responsible for increased CO2 levels in situations of increased oxygen extraction in the absence of decreased perfusion [21].
Positive_regulation (increased) of Gene_expression (levels) of CO2
4) Confidence 0.16 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.29 Pain Relevance 0
There are some data to suggest that altered substrate metabolism in the gastrointestinal mucosa may also influence CO2 production.
Positive_regulation (influence) of Gene_expression (production) of CO2
5) Confidence 0.16 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.10 Pain Relevance 0
CMRO2 for 5% CO2 inhalation, and a trend for a decrease in baseline CMRO2 and almost no stimulus-induced ?
Positive_regulation (induced) of Gene_expression (inhalation) of CO2
6) Confidence 0.06 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.19 Pain Relevance 0.10
The data shown in Figure 3 show a decrease of 15% for both gamma power and MUA for 6% CO2 inhalation which we, for sake of simplicity, translate into a ?
Positive_regulation (translate) of Gene_expression (translate) of CO2
7) Confidence 0.06 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.41 Pain Relevance 0
We found that the C2.3 fragment, containing the only known putative element (nt 992–1001 ARE), is not responsible for the low expression of the C2 fragment and thus this ARE, which is not conserved in rodents, is unlikely to be a destabilizing element.
Neg (not) Positive_regulation (responsible) of Gene_expression (expression) of C2
8) Confidence 0.06 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.07 Pain Relevance 0

General Comments

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