INT111289

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.00
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC4R) signal transducer activity (MC4R)
Anatomy Link Frequency
poly 1
MC4R (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 26 100.00 Very High Very High Very High
headache 4 96.76 Very High Very High Very High
antagonist 10 91.60 High High
melanocortin 1 receptor 9 76.48 Quite High
adenocard 7 39.28 Quite Low
carpal tunnel syndrome 1 30.56 Quite Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
noradrenaline 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 5 96.76 Very High Very High Very High
Vomiting 6 96.36 Very High Very High Very High
Weight Loss 3 95.60 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.16 Very High Very High Very High
Appetite Loss 33 89.72 High High
Obesity 101 87.00 High High
Body Weight 12 52.40 Quite High
Carpal Tunnel Syndrome 1 30.56 Quite Low
Pressure And Volume Under Development 6 29.44 Quite Low
Insulin Resistance 5 27.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results we concluded that, in the context of the MC4R poly(A) signal, a strong DSE and a consecutive stretch of adenosines are sufficient to direct efficient 3?
Regulation (context) of MC4R in poly
1) Confidence 0.43 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0 Pain Relevance 0
Our previous studies have suggested that in addition to exoloops 2 and 3, several transmembrane domains of MC4R may be important for AGRP binding.
Regulation (important) of MC4R
2) Confidence 0.42 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12
end processing is regulated in the human melanocortin 4 receptor gene (MC4R).
Regulation (regulated) of melanocortin 4 receptor gene
3) Confidence 0.37 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0.08 Pain Relevance 0
The only available clinical trial data on the effect of an MC4R agonist was conducted with adrenocorticotropic hormone (an agonist of MC4R) to assess its potential to cause weight reduction in humans.
Regulation (effect) of MC4R associated with weight loss and agonist
4) Confidence 0.21 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.92 Pain Relevance 0.66

General Comments

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