INT111298

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.42
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACTN4) nucleus (ACTN4) protein complex (ACTN4)
cytoplasm (ACTN4)
Anatomy Link Frequency
smooth muscle 1
epithelial cells 1
endometrium 1
lung 1
sperm 1
ACTN4 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 648 99.44 Very High Very High Very High
member 8 1 93.04 High High
TRP channel 1 82.16 Quite High
corticosteroid 1 80.48 Quite High
Mechanosensation 1 76.48 Quite High
cINOD 1 40.80 Quite Low
Migraine 1 25.00 Low Low
pain pelvic 12 5.00 Very Low Very Low Very Low
Dismenorea 10 5.00 Very Low Very Low Very Low
Mechanotransduction 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Focal Segmental Glomerulosclerosis 9 100.00 Very High Very High Very High
Nephrotic Syndrome 2 100.00 Very High Very High Very High
Endometriosis 828 99.84 Very High Very High Very High
Adhesions 150 99.84 Very High Very High Very High
Ovarian Cancer 90 98.16 Very High Very High Very High
Proteinuria 1 96.80 Very High Very High Very High
Disease 73 95.72 Very High Very High Very High
Renal Failure 1 86.84 High High
Endometroid Carcinoma 6 82.04 Quite High
Chronic Renal Failure 1 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACTN4, which we find strongly expressed in the endometriotic samples, is another candidate gene possibly involved in the pathogenesis of endometriosis.
Gene_expression (expressed) of ACTN4 associated with endometriosis
1) Confidence 0.70 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.25 Pain Relevance 0.45
Although, the comparison of gene expression profiles between endometriosis and normal endometrium was done for the proliferative phase, AXL, SHC1, and ACTN4 (discussed below) were also overexpressed during secretory phase in ovarian endometriosis.
Gene_expression (overexpressed) of ACTN4 in endometrium associated with endometriosis
2) Confidence 0.60 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.17 Pain Relevance 0.42
Enhanced cytoplasmic expression of ACTN4 is related to increased cell motility and invasion [51] and ACTN4 has recently been implicated in breast, lung, colorectal and ovarian cancers [52-54].
Gene_expression (expression) of ACTN4 in lung associated with ovarian cancer
3) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.21 Pain Relevance 0.45
Interestingly, enhanced cytoplasmic expression of ACTN4 is observed in about 60% of endometrioid and clear cell ovarian cancers [54], both of which have been suggested to possibly arise, at least in some cases, from endometriosis.
Gene_expression (expression) of ACTN4 associated with endometriosis and ovarian cancer
4) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.11 Pain Relevance 0.42
AXL, SHC1, and ACTN4, all shown to be overexpressed in endometriotic epithelial cells by SAGE, were selected for IHC validation.
Gene_expression (overexpressed) of ACTN4 in epithelial cells associated with endometriosis
5) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.71 Pain Relevance 0.26
Furthermore, since PI3K can control nuclear translocation of ACTN4, activation of the PI3K-Akt pathway in endometriosis may facilitate enhanced cytoplasmic expression of ACTN4, and may contribute the cell motility and invasion observed in endometriosis.
Gene_expression (expression) of ACTN4 associated with endometriosis
6) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.01 Pain Relevance 0.38
There is little information available on the effects of such treatment on the progression of FSGS.
Gene_expression (progression) of FSGS associated with focal segmental glomerulosclerosis
7) Confidence 0.51 Published 2003 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 12817066 Disease Relevance 0.84 Pain Relevance 0.04
Mutations in five genes have been found to cause inherited nephrotic syndromes and FSGS.
Gene_expression (syndromes) of FSGS associated with nephrotic syndrome
8) Confidence 0.16 Published 2008 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 18434567 Disease Relevance 0.50 Pain Relevance 0.17
Alpha actinin is known to be present in adhesion plaques and dense bodies in smooth muscle where it links the extracellular matrix to the actin cytoskeleton and the contractile filaments.
Gene_expression (present) of actinin in smooth muscle associated with adhesions
9) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.49 Pain Relevance 0
We were unable to identify p130 Cas in these samples by mass spectrometry, probably because of the relatively low abundance of this signaling molecule compared to cytoskeletal proteins such as CaD, myosin, alpha actinin and filamin.


Gene_expression (abundance) of actinin
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.34 Pain Relevance 0
Interestingly the alpha 4 isoform is found exclusively in the mid region of the sperm tail.
Gene_expression (found) of alpha 4 isoform in sperm
11) Confidence 0.06 Published 2007 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 18044013 Disease Relevance 0 Pain Relevance 0
Downregulation of FAK, talin1, talin 2, profilin, tensin and Arp2 was noticed in treated 5310 cells whereas in 4910 cells, FAK, talin1, talin2, vinculin, actinin, tensin and Arp2 levels were reduced with both MU-sh and MC-sh treatments (Fig. 8A).
Gene_expression (levels) of actinin
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.42 Pain Relevance 0
-actinin and vinculin protein expressions were reduced only in MC-sh treated 5310 xenografts.
Gene_expression (expressions) of actinin
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.35 Pain Relevance 0

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