INT111304

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
Anatomy Link Frequency
DA neurons 2
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 5 99.92 Very High Very High Very High
Substantia nigra 40 87.48 High High
Enkephalin 1 74.92 Quite High
imagery 45 73.48 Quite High
midbrain 23 64.96 Quite High
Eae 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.90 Very High Very High Very High
Death 4 99.30 Very High Very High Very High
Toxicity 4 69.28 Quite High
Hypertrophy 6 15.84 Low Low
Disease 34 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Supranuclear Palsy 3 5.00 Very Low Very Low Very Low
Multiple System Atrophy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was mirrored by an 82.2 ± 2.0% reduction in NeuN-positive (+) cells (10,380 ± 934 vs. 1825 ± 236; p < 0.001; Figure 5B), strongly suggesting cell death of A9 DA neurons rather than down-regulation of TH expression in atrophic neurons.
Regulation (regulation) of Gene_expression (expression) of TH in DA neurons associated with death
1) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2824797 Disease Relevance 0.17 Pain Relevance 0.27
Changes in expression of transmitter-synthesizing enzymes--tyrosine hydroxylase, dopamine beta-hydroxylase and choline acetyltransferase.
Regulation (Changes) of Gene_expression (expression) of tyrosine hydroxylase associated with dopamine
2) Confidence 0.02 Published 2003 Journal Pol J Vet Sci Section Title Doc Link 12817784 Disease Relevance 0.40 Pain Relevance 0.17

General Comments

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