INT111335

Context Info Confidence 0.75 First Reported 1999 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 57 Total Number 59 Disease Relevance 55.51 Pain Relevance 10.38

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1) extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)

Anatomy Link Frequency plaque 3 head 3 epithelial cells 2 neck 2 Endothelial cells 2 HSPD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 868 100.00 Arthritis 114 99.98 Osteoarthritis 35 99.70 rheumatoid arthritis 437 99.60 Angina 56 99.12 cytokine 289 97.30 Pain 20 97.20 Crohn's disease 99 96.76 Infliximab 6 94.72 cINOD 11 91.56

Disease Link Frequency Relevance Heat INFLAMMATION 1003 100.00 Shock 224 100.00 Ovarian Cancer 11 100.00 Experimental Arthritis 12 99.98 Mycobacterial Infection 22 99.88 Chlamydia Infection 75 99.84 Arthritis 109 99.72 Osteoarthritis 68 99.70 Epstein-barr Virus 27 99.70 Atherosclerosis 412 99.66

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Anatomy

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Speculation

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Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells.

Gene_expression (Overexpression) of 60-kDa heat shock protein in epithelial cells associated with shock

1) Confidence 0.75 Published 2010 Journal Life Sci. Section Title Doc Link 20159025 Disease Relevance 0.27 Pain Relevance 0.18

In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells.

Gene_expression (overexpression) of HSP60 in epithelial cells

2) Confidence 0.74 Published 2010 Journal Life Sci. Section Abstract Doc Link 20159025 Disease Relevance 0.26 Pain Relevance 0.18

Therefore, the present study evaluates the expressions of both HSP60 homologues in advanced human coronary lesions and a correlation between intimal tissuebound protein and serum antibodies (Ab) to HSP65.

Gene_expression (expressions) of HSP60

3) Confidence 0.73 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 1.03 Pain Relevance 0.08

For the first time, our data demonstrate a significant correlation between the intimal expression of these HSP60 homologues and serum HSP65 antibodies, thereby suggesting that humoral immune reactions to bacterial and human HSPs may play an important role in coronary atherosclerosis and plaque instability.

Gene_expression (expression) of HSP65 in plaque associated with atherosclerosis

4) Confidence 0.73 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.76 Pain Relevance 0

For the first time, our data demonstrate a significant correlation between the intimal expression of these HSP60 homologues and serum HSP65 antibodies, thereby suggesting that humoral immune reactions to bacterial and human HSPs may play an important role in coronary atherosclerosis and plaque instability.

Gene_expression (expression) of HSP60 in plaque associated with atherosclerosis

5) Confidence 0.73 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.76 Pain Relevance 0

In addition, inflamed biopsies showed an abundance of HSP60 expression, including in CD4 positive cells, confirming visually a direct link between immunologically relevant cells and expression of HSP in the presence of chronic inflammation.

Gene_expression (expression) of HSP60 associated with inflammation

6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.93 Pain Relevance 0.49

In this respect, a chronic persistent Chlamydia pneumoniae infection, indicated by the presence of chlamydial heat shock protein 60 (cHSP 60), is of central interest.

Gene_expression (presence) of heat shock protein 60 associated with shock, chlamydia infection and infection

7) Confidence 0.64 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.90 Pain Relevance 0.06

Most interestingly, cHSP60 revealed no relationship with anti-Chlamydia pneumoniae-IgG/IgA titers, whereas expression of cHSP60 as well as that of hHSP60 correlated with anti-HSP65-Ab titers (r=0.50, p<0.01, and r=0.42, p<0.05, respectively).cHSP60 and hHSP60 colocalize within coronary primary atheroma, most prevalent in lesions associated with ACS.

Gene_expression (expression) of cHSP60 associated with atherosclerosis and chlamydia infection

8) Confidence 0.64 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.89 Pain Relevance 0.06

Most interestingly, cHSP60 revealed no relationship with anti-Chlamydia pneumoniae-IgG/IgA titers, whereas expression of cHSP60 as well as that of hHSP60 correlated with anti-HSP65-Ab titers (r=0.50, p<0.01, and r=0.42, p<0.05, respectively).cHSP60 and hHSP60 colocalize within coronary primary atheroma, most prevalent in lesions associated with ACS.

Gene_expression (expression) of hHSP60 associated with atherosclerosis and chlamydia infection

9) Confidence 0.64 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.89 Pain Relevance 0.06

In this respect, a chronic persistent Chlamydia pneumoniae infection, indicated by the presence of chlamydial heat shock protein 60 (cHSP 60), is of central interest.

Gene_expression (presence) of cHSP 60 associated with shock, chlamydia infection and infection

10) Confidence 0.64 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12819994 Disease Relevance 0.91 Pain Relevance 0.06

Considering that mycobacterial heat-shock protein 65 (hsp65) gene transfer can elicit a profound antitumoral effect, this study aimed to establish the safety, maximum-tolerated dose (MTD) and preliminary efficacy of DNA-hsp65 immunotherapy in patients with advanced head and neck squamous cell carcinoma (HNSCC).

Gene_expression (transfer) of hsp65 in head associated with shock and skin cancer

11) Confidence 0.60 Published 2008 Journal Cancer Gene Ther. Section Abstract Doc Link 18535616 Disease Relevance 0.44 Pain Relevance 0

MAIN METHODS: cDNA of human HSP60 or HSP70 was transfected to rat small intestinal (IEC-6) cells, and HSP60- or HSP70-overexpressing cells were cloned.

Gene_expression (overexpressing) of HSP60 in IEC-6

12) Confidence 0.57 Published 2010 Journal Life Sci. Section Body Doc Link 20159025 Disease Relevance 0 Pain Relevance 0

Most attention has focused on circulating levels of the co-chaperone of HSP10, a protein termed HSP60.

Gene_expression (chaperone) of HSP60

13) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.45 Pain Relevance 0.03

However, HSP60 levels were stratified into those with: undetectable, between 1 and 1,000 ng/ml and >1,000 ng/ml HSP60 and we found a significant difference between controls and patients in the numbers of individuals having medium (between 1 and 1,000ng/ml) levels of circulating HSP60.

Gene_expression (stratified) of HSP60

14) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.69 Pain Relevance 0

Moreover, unlike conventional acute phase proteins that are largely synthesized in the liver, HSP10 and HSP60 are found in every cell as nuclear encoded genes which function within the mitochondria.

Gene_expression (found) of HSP60 in liver

15) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.56 Pain Relevance 0.15

However, HSP60 levels were stratified into those with: undetectable, between 1 and 1,000 ng/ml and >1,000 ng/ml HSP60 and we found a significant difference between controls and patients in the numbers of individuals having medium (between 1 and 1,000ng/ml) levels of circulating HSP60.

Gene_expression (levels) of HSP60

16) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.68 Pain Relevance 0

Comparison of these three distinct concentration bands revealed a significantly higher number of periodontal patients with intermediate levels of HSP60 compared to controls.

Gene_expression (levels) of HSP60 in bands

17) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.77 Pain Relevance 0.28

It is interesting to speculate whether individuals with low levels of HSP60 have their local anti-bacterial defences compromised by the action of this protein?

Gene_expression (levels) of HSP60

18) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.85 Pain Relevance 0.26

The factors leading to synovial HSP60 expression are not known, but heat is obviously not the only factor because normal and osteoarthritic synovial membranes also express this stress protein.

Gene_expression (expression) of HSP60 associated with stress and osteoarthritis

19) Confidence 0.56 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.26 Pain Relevance 0.30

Interestingly, rat strains resistant to adjuvant arthritis express HSP60 abundantly in the synovial membrane, whereas arthritis-prone Lewis rats fail to show a significant expression of HSP60, an observation that suggests a protective role of this molecule against arthritis [27].

Gene_expression (express) of HSP60 associated with experimental arthritis, sprains and strains and arthritis

20) Confidence 0.56 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.04 Pain Relevance 0.30

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