INT111335
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells. | |||||||||||||||
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In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells. | |||||||||||||||
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Therefore, the present study evaluates the expressions of both HSP60 homologues in advanced human coronary lesions and a correlation between intimal tissuebound protein and serum antibodies (Ab) to HSP65. | |||||||||||||||
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For the first time, our data demonstrate a significant correlation between the intimal expression of these HSP60 homologues and serum HSP65 antibodies, thereby suggesting that humoral immune reactions to bacterial and human HSPs may play an important role in coronary atherosclerosis and plaque instability. | |||||||||||||||
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For the first time, our data demonstrate a significant correlation between the intimal expression of these HSP60 homologues and serum HSP65 antibodies, thereby suggesting that humoral immune reactions to bacterial and human HSPs may play an important role in coronary atherosclerosis and plaque instability. | |||||||||||||||
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In addition, inflamed biopsies showed an abundance of HSP60 expression, including in CD4 positive cells, confirming visually a direct link between immunologically relevant cells and expression of HSP in the presence of chronic inflammation. | |||||||||||||||
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In this respect, a chronic persistent Chlamydia pneumoniae infection, indicated by the presence of chlamydial heat shock protein 60 (cHSP 60), is of central interest. | |||||||||||||||
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Most interestingly, cHSP60 revealed no relationship with anti-Chlamydia pneumoniae-IgG/IgA titers, whereas expression of cHSP60 as well as that of hHSP60 correlated with anti-HSP65-Ab titers (r=0.50, p<0.01, and r=0.42, p<0.05, respectively).cHSP60 and hHSP60 colocalize within coronary primary atheroma, most prevalent in lesions associated with ACS. | |||||||||||||||
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Most interestingly, cHSP60 revealed no relationship with anti-Chlamydia pneumoniae-IgG/IgA titers, whereas expression of cHSP60 as well as that of hHSP60 correlated with anti-HSP65-Ab titers (r=0.50, p<0.01, and r=0.42, p<0.05, respectively).cHSP60 and hHSP60 colocalize within coronary primary atheroma, most prevalent in lesions associated with ACS. | |||||||||||||||
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In this respect, a chronic persistent Chlamydia pneumoniae infection, indicated by the presence of chlamydial heat shock protein 60 (cHSP 60), is of central interest. | |||||||||||||||
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Considering that mycobacterial heat-shock protein 65 (hsp65) gene transfer can elicit a profound antitumoral effect, this study aimed to establish the safety, maximum-tolerated dose (MTD) and preliminary efficacy of DNA-hsp65 immunotherapy in patients with advanced head and neck squamous cell carcinoma (HNSCC). | |||||||||||||||
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MAIN METHODS: cDNA of human HSP60 or HSP70 was transfected to rat small intestinal (IEC-6) cells, and HSP60- or HSP70-overexpressing cells were cloned. | |||||||||||||||
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Most attention has focused on circulating levels of the co-chaperone of HSP10, a protein termed HSP60. | |||||||||||||||
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However, HSP60 levels were stratified into those with: undetectable, between 1 and 1,000 ng/ml and >1,000 ng/ml HSP60 and we found a significant difference between controls and patients in the numbers of individuals having medium (between 1 and 1,000ng/ml) levels of circulating HSP60. | |||||||||||||||
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Moreover, unlike conventional acute phase proteins that are largely synthesized in the liver, HSP10 and HSP60 are found in every cell as nuclear encoded genes which function within the mitochondria. | |||||||||||||||
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However, HSP60 levels were stratified into those with: undetectable, between 1 and 1,000 ng/ml and >1,000 ng/ml HSP60 and we found a significant difference between controls and patients in the numbers of individuals having medium (between 1 and 1,000ng/ml) levels of circulating HSP60. | |||||||||||||||
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Comparison of these three distinct concentration bands revealed a significantly higher number of periodontal patients with intermediate levels of HSP60 compared to controls. | |||||||||||||||
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It is interesting to speculate whether individuals with low levels of HSP60 have their local anti-bacterial defences compromised by the action of this protein? | |||||||||||||||
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The factors leading to synovial HSP60 expression are not known, but heat is obviously not the only factor because normal and osteoarthritic synovial membranes also express this stress protein. | |||||||||||||||
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Interestingly, rat strains resistant to adjuvant arthritis express HSP60 abundantly in the synovial membrane, whereas arthritis-prone Lewis rats fail to show a significant expression of HSP60, an observation that suggests a protective role of this molecule against arthritis [27]. | |||||||||||||||
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General Comments
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