INT111340

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.83
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYCS) transport (CYCS) mitochondrion (CYCS)
small molecule metabolic process (CYCS) nucleus (CYCS)
Anatomy Link Frequency
neuronal 2
MCF-7 2
CYCS (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 16 94.96 High High
COX-2 inhibitor 1 89.12 High High
cINOD 4 81.68 Quite High
local anesthetic 1 78.40 Quite High
Calcium channel 1 74.68 Quite High
antagonist 1 73.40 Quite High
Morphine 1 68.48 Quite High
qutenza 2 50.00 Quite Low
Dopamine 1 50.00 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 29 99.84 Very High Very High Very High
Death 10 98.80 Very High Very High Very High
Stress 3 93.36 High High
Parkinson's Disease 1 93.00 High High
Breast Cancer 6 91.48 High High
Colon Cancer 4 90.96 High High
Cardiovascular Disorder Under Development 2 87.36 High High
Drug Induced Neurotoxicity 4 84.96 Quite High
Leukemia 1 83.20 Quite High
INFLAMMATION 2 81.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, bupivacaine did not induce either mitochondrial permeability transition (PT) or release of cytochrome c in experiments with isolated mitochondria.
Neg (not) Positive_regulation (induce) of Localization (release) of cytochrome c
1) Confidence 0.67 Published 2003 Journal J Toxicol Sci Section Abstract Doc Link 12820540 Disease Relevance 0.79 Pain Relevance 0.08
We identified a potential role for BAX recruitment to the mitochondria, secondary to cytoplasmic translocation of TR3, in inducing cytochrome c release and in mediating apoptosis.
Positive_regulation (inducing) of Localization (release) of cytochrome c associated with apoptosis
2) Confidence 0.67 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.94 Pain Relevance 0.08
CMZ induced mitochondrial damage by increasing the levels of intracellular calcium, lowering the mitochondrial membrane potential, and thereby inducing cytochrome c release.
Positive_regulation (inducing) of Localization (release) of cytochrome c
3) Confidence 0.67 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19497364 Disease Relevance 0.76 Pain Relevance 0.07
Upon FR122047 treatment, there were apparent increases in the ratio of Bax to Bcl-2, mitochondrial cytochrome c release, and apoptosis in MCF-7 cells.
Positive_regulation (increases) of Localization (release) of cytochrome c in MCF-7 associated with apoptosis
4) Confidence 0.67 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.90 Pain Relevance 0.26
Release of cytochrome c from mitochondria, activation of caspase-3, and condensed nuclear chromatin were evident 6 h after capsaicin exposure, but cytotoxicity was unaffected by a pan-caspase inhibitor (zVAD-fmk, 50 microM).
Positive_regulation (activation) of Localization (Release) of cytochrome c
5) Confidence 0.49 Published 2010 Journal Br J Anaesth Section Body Doc Link 20354008 Disease Relevance 0 Pain Relevance 0
Conversely, a major increase in cytochrome c release, caspase 3-dependent apoptosis, and decreased metabolic neuronal viability were observed upon sequential exposure to Her and Coc.
Positive_regulation (increase) of Localization (release) of cytochrome c in neuronal associated with apoptosis and cocaine
6) Confidence 0.49 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.80 Pain Relevance 0.69
Incomplete scavenging of ROS and RNS particularly affects the mitochondrial lipid cardiolipin (CL), triggers the release of mitochondrial cytochrome c, and activates the intrinsic death pathway.
Positive_regulation (triggers) of Localization (release) of cytochrome c associated with death
7) Confidence 0.45 Published 2008 Journal Acc. Chem. Res. Section Abstract Doc Link 18193822 Disease Relevance 0.64 Pain Relevance 0

General Comments

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