INT111358

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.09
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
primary sensory neurons 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 86 100.00 Very High Very High Very High
tolerance 49 100.00 Very High Very High Very High
Glutamate 29 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
mu opioid receptor 26 99.80 Very High Very High Very High
amygdala 127 98.20 Very High Very High Very High
long-term potentiation 74 98.08 Very High Very High Very High
Analgesic 60 96.56 Very High Very High Very High
gABA 8 96.20 Very High Very High Very High
agonist 63 94.24 High High
Disease Link Frequency Relevance Heat
Shock 1 91.32 High High
Disease 19 50.00 Quite Low
Targeted Disruption 19 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cross-tolerance between CB1Rs and MORs
Regulation (Cross) of Localization (tolerance) of CB1Rs associated with mu opioid receptor and tolerance
1) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.48
NO and CB1 receptors are involved in mediating capsaicin-induced reduction of LA-LTP
Regulation (involved) of Localization (receptors) of CB1 associated with qutenza, long-term potentiation and amygdala
2) Confidence 0.34 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.41
Dysregulation of glutamate release is compounded by loss of DA D2, CB1, mGluR2/3 and other presynaptic receptors regulating glutamate release at corticostriatal terminals.
Regulation (regulating) of Localization (release) of CB1 associated with glutamate
3) Confidence 0.27 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.09 Pain Relevance 0.44
These data indicate that anandamide may regulate CGRP release from capsaicin-sensitive primary sensory neurons in vivo, and that the net effect of anandamide on transmitter release from capsaicin-sensitive primary sensory neurons depends on the concentration of anandamide and the state of the CB1 receptor and VR1.
Spec (may) Regulation (regulate) of Spec (may) Localization (release) of CB1 receptor in primary sensory neurons associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.02 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823468 Disease Relevance 0 Pain Relevance 1.20

General Comments

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