INT111359

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 2003
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 55
Total Number 57
Disease Relevance 11.25
Pain Relevance 27.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 4
synapse 4
nerve 3
nervous system 2
brainstem 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 1020 100.00 Very High Very High Very High
agonist 702 100.00 Very High Very High Very High
Endocannabinoid 602 100.00 Very High Very High Very High
tolerance 263 100.00 Very High Very High Very High
Glutamate 211 100.00 Very High Very High Very High
Cannabinoid receptor 155 100.00 Very High Very High Very High
mu opioid receptor 134 100.00 Very High Very High Very High
qutenza 98 100.00 Very High Very High Very High
Cholecystokinin 15 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 403 99.16 Very High Very High Very High
Nociception 45 98.64 Very High Very High Very High
Targeted Disruption 99 98.00 Very High Very High Very High
Pain 73 97.92 Very High Very High Very High
Demyelinating Disease 10 97.80 Very High Very High Very High
Neuropathic Pain 119 96.56 Very High Very High Very High
Obesity 6 96.20 Very High Very High Very High
Vomiting 35 96.04 Very High Very High Very High
INFLAMMATION 47 95.72 Very High Very High Very High
Depression 399 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical experiments examined the distribution and localization of CB1 in the superficial dorsal horn of the spinal cord using specific antibodies.
Spec (examined) Localization (localization) of CB1 in dorsal horn
1) Confidence 0.81 Published 2009 Journal Anesthesiology Section Body Doc Link 19512863 Disease Relevance 0.17 Pain Relevance 0
The precise localization of CB1R and mGluR5 in cortical layers V/VI was studied by double immunoelectron microscopy (Fig 1B–F).
Localization (localization) of CB1R
2) Confidence 0.76 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.13
The present data suggest a presynaptic location of CB1R, consistent with other studies indicating that CB1R are present on pre-synaptic nerve terminals elsewhere in the hippocampal formation [24], although they are typically thought to be located on terminals of GABAergic neurons [51], [52],.
Localization (location) of CB1R in nerve associated with gabaergic
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.27 Pain Relevance 0.38
Also, we have preliminary data (not shown) of a co-localization of CB1 and green fluorescent protein (GFP) in alBNST of knock-in mice expressing GFP under the control of the glutamate decarboxylase 67 (GAD67) promoter [38].
Localization (localization) of CB1 associated with targeted disruption and glutamate
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.10 Pain Relevance 0.15
Furthermore, 30% and 35% of presynaptic boutons localize CB1 in alBNST of conditional mutant mice lacking CB1 mainly from GABAergic neurons (GABA-CB1-KO mice) and mainly from cortical glutamatergic neurons (Glu-CB1-KO mice), respectively.
Localization (localize) of CB1 in boutons associated with gaba and gabaergic
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810340 Disease Relevance 0.12 Pain Relevance 0.28
All these pieces of evidence point to a plausible subcellular localization of CB1 at inhibitory presynatic terminals in the alBNST as described in other brain regions [36], [37].
Localization (localization) of CB1 in brain
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.07 Pain Relevance 0.15
A preembedding silver-intensified immunogold method and an immunoperoxidase method were used for the co-localization of CB1 and the vesicular glutamate transporter 1 (vGluT1) in rat alBNST sections.
Localization (localization) of CB1 associated with glutamate
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.14 Pain Relevance 0.08
The localization of CB1 in GABAergic and glutamatergic presynaptic terminals is well documented [36], [38]–[43], and many studies in different brain regions have demonstrated that cannabinoids acting at presynaptic CB1 receptors depress inhibitory and excitatory synaptic transmission [16], [44]–[47].
Localization (localization) of CB1 in brain associated with cannabinoid and gabaergic
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.05 Pain Relevance 0.36
Here, we report that CB1 is localized on presynaptic membranes of about 55% of immunopositive synaptic terminals for the vesicular glutamate transporter 1 (vGluT1), which contain abundant spherical, clear synaptic vesicles and make asymmetrical synapses with alBNST neurons.
Localization (localized) of CB1 in neurons associated with glutamate
9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810340 Disease Relevance 0.15 Pain Relevance 0.27
Nevertheless, the absence of RGS9 did not affect the activity of WIN55,212-2 or its capacity to produce CB1R desensitization.
Localization (desensitization) of CB1R
10) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.30
Ten fractions (4 mL each) were collected, the proteins concentrated, and the CB1Rs immunoprecipitated and analyzed by Western blotting.


Localization (immunoprecipitated) of CB1Rs
11) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.05 Pain Relevance 0
In contrast, methanandamide induced a low to moderate internalization of the CB1R (Fig. 3B).
Localization (internalization) of CB1R
12) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.58
Given the prominent presynaptic localization of cannabinoid CB1 receptors, together with its mainly inhibitory actions, cannabinoids have been proposed as local retrograde modulators, with an important role in modulating essential physiological functions and contributing in diverse synaptic plasticity phenomena [59–62].
Localization (localization) of CB1 associated with cannabinoid
13) Confidence 0.74 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.17 Pain Relevance 0.28
Based on our present results showing functional presynaptic CB1R at pyramidal cells synapses and our ultrastructural data showing the presynaptic localization of CB1R, we tested the existence of eCB-dependent plasticity within the PrPFC.
Localization (localization) of CB1R in synapses associated with pyramidal cell
14) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.29 Pain Relevance 0.47
The preembedding silver-intensified immunogold method described previously [27] was used for the localization of CB1R in prPFC sections processed for the immunoperoxidase method with either mGluR5 or DGL-?
Localization (localization) of CB1R
15) Confidence 0.71 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0
CB1 has been located in the central nervous system and peripheral tissues and CB2 appeared mainly in the cells of the immune system (Fride and Mechoulam 2003) although it has now also been identified in brainstem, cortex and cerebellum neurons (Van Sickle et al 2005).
Localization (located) of CB1 in cortex associated with medulla and central nervous system
16) Confidence 0.71 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656312 Disease Relevance 0.13 Pain Relevance 0.64
In an attempt to provide an explanation for these conflicting results, further investigations aimed at evaluating the effect of the increase of CB 1 activation and CB1 receptor blockade under identical experimental conditions and assessing the activation and blockade of CB1 receptors in different animal models of depression should be performed.
Localization (blockade) of CB1 associated with depression
17) Confidence 0.70 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.39 Pain Relevance 0.44
Localization and Function of the Cannabinoid CB1 Receptor in the Anterolateral Bed Nucleus of the Stria Terminalis

Background

Localization (Localization) of CB1 Receptor in Nucleus associated with cannabinoid
18) Confidence 0.70 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2810340 Disease Relevance 0.19 Pain Relevance 0.21
We analysed the distribution of TRPV1 receptors in the ferret brainstem and, for comparison, the co-localization of CB1 and TRPV1 receptors in the mouse brainstem.
Localization (co-localization) of CB1 in brainstem associated with medulla
19) Confidence 0.69 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17459108 Disease Relevance 0.90 Pain Relevance 0.79
CB1 is mainly localized to presynaptic axon terminals and activated by endocannabinoids synthesized and released by the postsynaptic neurons, a phenomenon otherwise known as retrograde signaling [12].
Localization (localized) of CB1 in neurons associated with endocannabinoid
20) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox