INT11136

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.13
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
lymphocytes 2
T cell 2
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 25 99.60 Very High Very High Very High
Hyperalgesia 6 98.98 Very High Very High Very High
Neuritis 5 96.40 Very High Very High Very High
intrathecal 1 90.76 High High
Thermal hyperalgesia 1 89.48 High High
monoamine 2 86.56 High High
antidepressant 3 84.16 Quite High
Visceral pain 4 76.96 Quite High
cytokine 3 76.96 Quite High
Pain 4 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.60 Very High Very High Very High
Hyperalgesia 7 98.98 Very High Very High Very High
Experimental Autoimmune Neuritis 5 96.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 96.00 Very High Very High Very High
Heart Rate Under Development 1 95.12 Very High Very High Very High
Cerebral Palsy 8 90.32 High High
Autism 82 89.76 High High
Necrosis 1 85.36 High High
Cancer 1 85.00 Quite High
Injury 1 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present experiments, we found that: (1) selective inhibition of glia metabolism with intrathecal (i.t.) administration of fluorocitrate (1 nmol) results in a marked, but reversible, attenuation of the persistent thermal and mechanical hyperalgesia produced by intraplantar zymosan (5 mg); (2) selective inhibition of the inducible form of nitric oxide synthase (iNOS) with i.t. aminoguanidine (1 pmol-1 nmol) resulted in a dose-dependent inhibition of the persistent thermal, but not mechanical hyperalgesia produced by intraplantar zymosan (5 mg); (3) i.t. coadministration of interleukin 1 beta (IL1 beta; 10 ng) and interferon gamma (IFN; 1000 U) resulted in expression of the message for iNOS 8 hr after administration assessed using reverse-transcription polymerase chain reaction (RT-PCR) and Southern blot analysis; and (4) i.t. administration of lipopolysaccharide (LPS; 150 micrograms) produced a time-dependent thermal hyperalgesia compared with saline treated-rats (15 microliters).
Positive_regulation (resulted) of Localization (coadministration) of interferon gamma associated with hyperalgesia, thermal hyperalgesia and intrathecal
1) Confidence 0.49 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7532831 Disease Relevance 0.72 Pain Relevance 0.65
The action of several drugs on induced T cell secretion of IFN-gamma suggests that the mechanisms for the suppressive effect of zimeldine and norzimeldine on EAN symptoms can be due to an action on myelin T cell autoreactivity.
Positive_regulation (induced) of Localization (ecretion ) of IFN-gamma in T cell associated with neuritis
2) Confidence 0.45 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.38 Pain Relevance 0.48
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Positive_regulation (activation-induced) of Localization (release) of IFN-gamma in lymphocytes
3) Confidence 0.13 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.67 Pain Relevance 0.63
Since the mechanism of action of HBOT in autism may be different than in CP [11], including decreasing inflammation (as reviewed in the background section of this paper), it is entirely possible that clinical benefits may arise from purely increasing the atmosphere pressure delivered, because increased pressure delivery without additional oxygen appears to decrease inflammation (as measured by an inhibition of interferon-gamma release), and delivery of oxygen by mask without any increase in pressure may actually increase inflammation (as measured by an increase in interferon-gamma release) [44].
Positive_regulation (increase) of Localization (release) of interferon-gamma associated with autism, inflammation and cerebral palsy
4) Confidence 0.01 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 0.74 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox