INT111365

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.52
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
paw 4
sensory neurons 2
neurons 2
spinal cord 2
brains 2
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 80 100.00 Very High Very High Very High
Cannabinoid receptor 57 100.00 Very High Very High Very High
Inflammation 53 100.00 Very High Very High Very High
Pain 50 100.00 Very High Very High Very High
Peripheral nerve injury 8 99.98 Very High Very High Very High
agonist 85 99.64 Very High Very High Very High
Spinal cord 86 99.52 Very High Very High Very High
Thalamus 178 98.36 Very High Very High Very High
Lasting pain 42 98.36 Very High Very High Very High
ischemia 2 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 23 99.98 Very High Very High Very High
INFLAMMATION 47 99.96 Very High Very High Very High
Neuropathic Pain 172 98.92 Very High Very High Very High
Hypoxia 2 98.56 Very High Very High Very High
Pain 87 98.36 Very High Very High Very High
Cv Unclassified Under Development 2 98.24 Very High Very High Very High
Vomiting 4 96.96 Very High Very High Very High
Weight Gain 7 96.48 Very High Very High Very High
Post Operative Pain 66 92.60 High High
Ganglion Cysts 4 83.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models.
Positive_regulation (Induction) of Gene_expression (expression) of CB2 in spinal cord associated with inflammation, lasting pain, neuropathic pain and spinal cord
1) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12823482 Disease Relevance 0.75 Pain Relevance 1.37
We report here that chronic pain models associated with peripheral nerve injury, but not peripheral inflammation, induce CB2 receptor expression in a highly restricted and specific manner within the lumbar spinal cord.
Positive_regulation (induce) of Gene_expression (expression) of CB2 in peripheral nerve associated with nervous system injury, inflammation, lasting pain, spinal cord and peripheral nerve injury
2) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823482 Disease Relevance 0.77 Pain Relevance 0.93
CB2 receptor expression is also induced in the brains of rats subjected to hypoxia–ischemia, although in this situation the receptors appear to be located on non-neuronal cells including resident microglia or invading monocytes (Ashton et al., 2007).
Positive_regulation (induced) of Gene_expression (expression) of CB2 receptor in brains associated with hypoxia and ischemia
3) Confidence 0.69 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.65 Pain Relevance 0.43
Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons.
Positive_regulation (induces) of Gene_expression (expression) of cannabinoid receptor 2 protein in sensory neurons associated with nervous system injury, cannabinoid receptor and peripheral nerve injury
4) Confidence 0.60 Published 2005 Journal Neuroscience Section Title Doc Link 16084654 Disease Relevance 0.33 Pain Relevance 0.91
As there is no evidence for an increased population of neuroimmune cells in the thalamus of neuropathic rats, the most parsimonious explanation of the present data is an increased expression of CB2 receptors on thalamic neurons, although this requires verification by immunohistochemical approaches.
Positive_regulation (increased) of Gene_expression (expression) of CB2 in neurons associated with neuropathic pain and thalamus
5) Confidence 0.50 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.69 Pain Relevance 0.46
Neutral antagonist and binding properties were confirmed in HEK-293 cells transfected with human CB1 or CB2 receptors.
Positive_regulation (transfected) of Gene_expression (transfected) of CB2 associated with antagonist
6) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17959701 Disease Relevance 0.60 Pain Relevance 0.35
Moreover, the appearance of CB2 expression coincides with the appearance of activated microglia.
Positive_regulation (appearance) of Gene_expression (expression) of CB2 in microglia
7) Confidence 0.47 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823482 Disease Relevance 0.74 Pain Relevance 0.89
In order to examine expression of Iba-1 (a microglial marker), GFAP (an astrocytic marker), ED2/CD163 (a perivascular cell marker) and CB1/CB2 receptor and CB1/CB2 receptor co-localization with other cell markers in response to paw incision, untreated animals received paw incision surgery and were perfused as described below on days 1, 3 and 9 after surgery (n?
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of CB2 receptor in paw
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.07 Pain Relevance 0.16
In order to examine expression of Iba-1 (a microglial marker), GFAP (an astrocytic marker), ED2/CD163 (a perivascular cell marker) and CB1/CB2 receptor and CB1/CB2 receptor co-localization with other cell markers in response to paw incision, untreated animals received paw incision surgery and were perfused as described below on days 1, 3 and 9 after surgery (n?
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of CB2 receptor in paw
9) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.07 Pain Relevance 0.16
We then administered concomitant CB1 and CB2 receptor antagonists/inverse agonists (AM281 and AM630, 1 mg.kg?
Positive_regulation (concomitant) of Gene_expression (antagonists) of CB2 receptor associated with antagonist and agonist
10) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.84 Pain Relevance 1.17

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