INT11137

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
lymphocytes 2
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 25 99.60 Very High Very High Very High
antidepressant 3 84.60 Quite High
Neuritis 5 77.60 Quite High
cytokine 2 77.52 Quite High
Visceral pain 4 76.96 Quite High
Pain 3 75.56 Quite High
Serotonin 1 65.52 Quite High
spastic colon 1 55.12 Quite High
monoamine 2 52.16 Quite High
withdrawal 3 9.36 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 99.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 96.56 Very High Very High Very High
Heart Rate Under Development 1 95.68 Very High Very High Very High
Cerebral Palsy 8 93.50 High High
Autism 82 92.94 High High
Necrosis 1 85.92 High High
Cancer 1 85.56 High High
Experimental Autoimmune Neuritis 5 77.60 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 76.96 Quite High
Pain 3 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the IFN-gamma secretion assay zimeldine, CPP 200, clomipramine and maprotiline all in a concentration-dependent mode reduced the number of IFN-gamma secreting cells while norzimeldine and imipramine did not affect the IFN-gamma secretion.
Negative_regulation (reduced) of Localization (secretion) of IFN-gamma
1) Confidence 0.38 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.43 Pain Relevance 0.49
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Negative_regulation (decreased) of Localization (release) of IFN-gamma in lymphocytes
2) Confidence 0.11 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.67 Pain Relevance 0.63
Since the mechanism of action of HBOT in autism may be different than in CP [11], including decreasing inflammation (as reviewed in the background section of this paper), it is entirely possible that clinical benefits may arise from purely increasing the atmosphere pressure delivered, because increased pressure delivery without additional oxygen appears to decrease inflammation (as measured by an inhibition of interferon-gamma release), and delivery of oxygen by mask without any increase in pressure may actually increase inflammation (as measured by an increase in interferon-gamma release) [44].
Negative_regulation (inhibition) of Localization (release) of interferon-gamma associated with autism, inflammation and cerebral palsy
3) Confidence 0.01 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 0.74 Pain Relevance 0.15

General Comments

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