INT111377

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 11.22
Pain Relevance 6.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ifih1) nucleus (Ifih1) intracellular (Ifih1)
helicase activity (Ifih1) DNA binding (Ifih1) cytoplasm (Ifih1)
Anatomy Link Frequency
blood 3
gastrocnemius 3
lungs 1
Ifih1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 77 99.98 Very High Very High Very High
psoriasis 63 99.82 Very High Very High Very High
Inflammation 240 96.44 Very High Very High Very High
Analgesic 7 94.80 High High
cva 12 92.08 High High
dexamethasone 7 89.36 High High
cytokine 24 88.68 High High
Inflammatory response 11 87.20 High High
Hippocampus 7 60.32 Quite High
cerebral cortex 7 59.28 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 100.00 Very High Very High Very High
Psoriasis 106 99.82 Very High Very High Very High
Necrosis 20 99.56 Very High Very High Very High
Cancer 13 99.38 Very High Very High Very High
Infection 54 99.00 Very High Very High Very High
Stress 393 98.52 Very High Very High Very High
Death 69 97.52 Very High Very High Very High
INFLAMMATION 248 96.44 Very High Very High Very High
Pleurisy 16 95.72 Very High Very High Very High
Increased Venous Pressure Under Development 5 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include Ifi27, Ifih1, Irf7 and Oas1b which were upregulated at 72 hr and 96 hr post infection except Becn1 that was over-expressed only at 72 hr post infection, and Spn which was over-expressed at all time points.


Positive_regulation (upregulated) of Ifih1 associated with urological neuroanatomy and infection
1) Confidence 0.60 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.40 Pain Relevance 0.21
Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.
Positive_regulation (elevations) of MDA associated with paracetamol
2) Confidence 0.47 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.73 Pain Relevance 1.13
AA increased serum AST, ALT, total sialic acid (TSA) and MDA as well as tissue TSA and MDA levels significantly with the highest increase observed at 4 h, but there was a decrease in blood and tissue GSH level.
Positive_regulation (increased) of MDA in blood associated with paracetamol
3) Confidence 0.47 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.70 Pain Relevance 0.97
Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.
Positive_regulation (increased) of MDA associated with paracetamol
4) Confidence 0.32 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.74 Pain Relevance 1.13
AA increased serum AST, ALT, total sialic acid (TSA) and MDA as well as tissue TSA and MDA levels significantly with the highest increase observed at 4 h, but there was a decrease in blood and tissue GSH level.
Positive_regulation (increased) of MDA in blood associated with paracetamol
5) Confidence 0.32 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.71 Pain Relevance 0.97
MDT also affected the levels of interleukin-1beta, tumor necrosis factor-alpha, NO and MDA which were induced by lambda-carrageenan.
Positive_regulation (induced) of MDA associated with necrosis and cancer
6) Confidence 0.13 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.31 Pain Relevance 0.58
GSH levels were reduced while MDA, MPO and oxidized protein levels were increased significantly following AA administration.
Positive_regulation (increased) of MDA associated with paracetamol and urological neuroanatomy
7) Confidence 0.08 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.63 Pain Relevance 0.63
Acetaminophen treatment caused a significant (P < 0.05-0.001) decrease in GSH levels whereas MDA levels and MPO activity were increased in both tissues.
Positive_regulation (increased) of MDA associated with paracetamol and urological neuroanatomy
8) Confidence 0.06 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.23 Pain Relevance 0.71
As shown in Figure 3h, MDA levels were significantly increased in the lungs of carrageenan-treated mice.
Positive_regulation (increased) of MDA in lungs
9) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.21 Pain Relevance 0.03
We ascertained that females had significantly higher levels of MDA in the red gastrocnemius (32%, P?
Positive_regulation (levels) of MDA in gastrocnemius
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.32 Pain Relevance 0
In accordance with the increase in MDA levels, there was a substantial upregulation in antioxidant enzymes, MnSOD (red gastrocnemius, 4-fold; white gastrocnemius, 2.2-fold) and Cu/Zn-SOD (red gastrocnemius, 2.6-fold) in CR vs.
Positive_regulation (increase) of MDA in gastrocnemius
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.27 Pain Relevance 0
This observation is consistent with the increased MDA, in conjunction with significantly elevated levels of Bax and the ratio of Bax/Bcl-2 protein content in CR vs.
Positive_regulation (increased) of MDA
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.87 Pain Relevance 0.04
In contrast to the effect of CR on increasing MDA, protein oxidation following CR is decreased in G93A mice.
Positive_regulation (increasing) of MDA
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.42 Pain Relevance 0
In our study, MDA and PC move in opposing directions as a consequence of CR, which is a finding that proposes some important questions, including whether an increase in PC is concordant with an increase in MDA.
Spec (whether) Positive_regulation (increase) of MDA
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.41 Pain Relevance 0
One of the novel aspects of this study is the CR-associated increase in MDA and TNF-?.
Positive_regulation (increase) of MDA
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.36 Pain Relevance 0.39
The marked increase in MnSOD in the red gastrocnemius (4-fold), although more than 2-fold higher than its reported activity in rat liver mitochondria [49], is most likely a compensatory upregulation to the 2-fold increase in MDA observed in the tissue of this diseased animal model.
Positive_regulation (increase) of MDA in gastrocnemius
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.26 Pain Relevance 0
Patients with psoriasis exhibit increased concentrations of MDA [51, 87, 89, 90] and ox-LDL [18] in the tissues and higher levels of TBA [43, 52, 87] and anti-ox-LDL autoantibody (AuAb-oxLDL) [50, 51, 87] in the blood.
Positive_regulation (increased) of MDA in blood associated with psoriasis
17) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.64 Pain Relevance 0.20

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