INT111387

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 20
Disease Relevance 7.43
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skeletal muscle 3
spinal 2
hypothalamus 2
testis 1
colon 1
xn (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.72 Very High Very High Very High
Pain 2 98.40 Very High Very High Very High
Analgesic 8 92.16 High High
anesthesia 19 73.20 Quite High
Potency 39 62.32 Quite High
vagus nerve 19 57.48 Quite High
IPN 1 30.64 Quite Low
Hyperalgesia 1 27.20 Quite Low
Dopamine 2 25.00 Low Low
antagonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 475 99.74 Very High Very High Very High
Apoptosis 285 99.52 Very High Very High Very High
Pain 2 98.40 Very High Very High Very High
Insulin Resistance 95 96.76 Very High Very High Very High
Amyloid Plaque 19 96.36 Very High Very High Very High
Diabetes Mellitus 342 94.48 High High
Cognitive Disorder 76 93.04 High High
Parkinson's Disease 19 90.24 High High
Death 76 88.56 High High
Aging 38 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel analogues of the minimal antinociceptive histogranin (HN) fragment Gly(7)-Gln-Gly-Arg(10), in which amino acids in positions 8, 9, and 10 were replaced by lipophilic amino acids and corresponding d-amino acid residues in combination with N- to C-terminal cyclization, were synthesized and tested in various animal models of pain.
Gene_expression (synthesized) of HN associated with pain and antinociceptive
1) Confidence 0.34 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12825947 Disease Relevance 0.10 Pain Relevance 0.36
While IGFBP-3 production is increased in AD brain [35], HN is expressed in the non-apoptotic hippocampal regions of Alzheimer's patients' brains and is absent in senile plaques [3].
Gene_expression (expressed) of HN in brain associated with apoptosis, disease and amyloid plaque
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 1.05 Pain Relevance 0.06
Despite little being known regarding the regulation of HN production in vivo, the major role of HN is believed to be promoting cell survival.
Gene_expression (production) of HN
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.76 Pain Relevance 0
HN was undetectable in the circulation during ICV infusion confirming that there was no leak of ICV infused HN (data not shown).
Gene_expression (undetectable) of HN
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
As presented in Fig. 3A, HN infusion resulted in a 10-fold increase in STAT-3 phosphorylation in hypothalamic tissues within an hour of ICV HN infusion (P<0.05).
Gene_expression (infusion) of HN
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Furthermore, the absence of any effect on phosphorylation levels of other signaling kinases, including AKT, demonstrates that the effects of HN are independent of hypo thalamic insulin signaling.
Gene_expression (effects) of HN
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.50 Pain Relevance 0
HN, N.S), a higher glucose infusion rate (GIR) was required to maintain euglycemia in the groups that received ICV HN (Fig. 2B).
Gene_expression (received) of ICV HN
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
In addition, the expression of the HN homolog RN tended to be decreased with age in the hypothalamus (P?
Gene_expression (expression) of HN in hypothalamus
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.22 Pain Relevance 0
Peripheral intravenous infusions of novel and potent HN derivatives reproduced the insulin-sensitizing effects of central HN.
Gene_expression (reproduced) of HN
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.86 Pain Relevance 0
Central HN activates mediators of insulin action in skeletal muscle
Gene_expression (activates) of HN in skeletal muscle
10) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Consistent with enhanced glucose uptake, insulin signaling in the skeletal muscle was significantly increased during ICV HN infusion, in spite of similar circulating insulin levels (Fig. 2L).
Gene_expression (infusion) of ICV HN in skeletal muscle
11) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
A primed-continuous ICV infusion of HN, F6AHN (total dose of 20 ug), dimerization deficient (DD) HN, STAT-3 inhibitor (75 pmol) , or artificial cerebro-spinal fluid (aCSF) was initiated at t?
Gene_expression (infusion) of HN in spinal
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.27 Pain Relevance 0.07
HN, N.S), GIR was significantly higher in the ICV HN group (P<0.05, Fig. 2D).
Gene_expression (higher) of HN
13) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
Peripheral intravenous infusions of novel and potent HN derivatives reproduced the insulin-sensitizing effects of central HN.
Gene_expression (reproduced) of HN
14) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.86 Pain Relevance 0
Endogenous HN is both an intracellular and secreted protein and has been detected in normal mouse testis and colon at specific stages of development [3].
Gene_expression (detected) of HN in colon
15) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.25 Pain Relevance 0
The link between the decrease in circulating levels of HN as well as levels in hypothalamus and skeletal muscle with age, in parallel with the increase in age- associated diseases such as AD and T2DM is extremely intriguing and warrants further investigation.
Gene_expression (levels) of HN in hypothalamus associated with diabetes mellitus and disease
16) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 1.01 Pain Relevance 0
A primed-continuous ICV infusion of HN, F6AHN (total dose of 20 ug), dimerization deficient (DD) HN, STAT-3 inhibitor (75 pmol) , or artificial cerebro-spinal fluid (aCSF) was initiated at t?
Gene_expression (infusion) of HN in spinal
17) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.27 Pain Relevance 0.07
HN, N.S), GIR was significantly higher in the ICV HN group (P<0.05, Fig. 2D).
Gene_expression (group) of ICV HN
18) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
The link between the decrease in circulating levels of HN as well as levels in hypothalamus and skeletal muscle with age, in parallel with the increase in age- associated diseases such as AD and T2DM is extremely intriguing and warrants further investigation.
Gene_expression (levels) of HN in skeletal muscle associated with diabetes mellitus and disease
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 1.01 Pain Relevance 0
Endogenous HN is both an intracellular and secreted protein and has been detected in normal mouse testis and colon at specific stages of development [3].
Gene_expression (detected) of HN in testis
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.25 Pain Relevance 0

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