INT11139

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 5.13
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LBR) small molecule metabolic process (LBR) nucleus (LBR)
DNA binding (LBR)
Anatomy Link Frequency
T lymphocytes 5
lymphocytes 2
erythrocyte 1
lamina 1
MNC 1
LBR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 137 98.88 Very High Very High Very High
narcan 14 98.38 Very High Very High Very High
rheumatoid arthritis 234 96.92 Very High Very High Very High
antidepressant 3 91.76 High High
anesthesia 3 89.12 High High
Neuritis 5 84.76 Quite High
Osteoarthritis 206 84.64 Quite High
halothane 1 83.76 Quite High
Arthritis 147 83.68 Quite High
Inflammation 223 78.40 Quite High
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 57 100.00 Very High Very High Very High
Herpes Virus Infection 1 100.00 Very High Very High Very High
Rheumatoid Arthritis 234 96.92 Very High Very High Very High
Cytomegalovirus Infection 22 95.60 Very High Very High Very High
Necrosis 11 90.88 High High
Cancer 106 90.52 High High
Hodgkin's Disease 231 90.48 High High
Lymphatic System Cancer 75 86.72 High High
Experimental Autoimmune Neuritis 5 84.76 Quite High
Osteoarthritis 209 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphocyte reactivity was determined by 3H-Thymidine incorporation during incubation with the mitogens phytohemagglutinin (PHA), pokeweed (PWM), and/or concanavalin A (Con A) and results expressed as the logarithm of scintillation counts per minute.
Gene_expression (expressed) of PHA in Lymphocyte
1) Confidence 0.75 Published 1986 Journal J. Pediatr. Surg. Section Abstract Doc Link 3488388 Disease Relevance 0.12 Pain Relevance 0.28
However, when T lymphocytes are costimulated with PHA or concanavalin A (Con A), leptin dose-dependently enhances the proliferation and activation of cultured T lymphocytes, achieving maximal effect at 10?
Gene_expression (dose) of PHA in T lymphocytes
2) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.06
, PHA (phytohemagglutinin) and PE and the production of IL-2 was quantified using the IL-2-specific ELISA according to the instructions of the manufacturer (R&D Systems).
Gene_expression (production) of PHA
3) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.15 Pain Relevance 0.07
, PHA (phytohemagglutinin) and PE and the production of IL-2 was quantified using the IL-2-specific ELISA according to the instructions of the manufacturer (R&D Systems).
Gene_expression (quantified) of PHA
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.15 Pain Relevance 0.07
Effect of IL-12 and IL-18 on PHA/PMA-stimulated PBMCs
Gene_expression (Effect) of PHA
5) Confidence 0.15 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.45
All individuals responded to PHA as determined by IFN?
Gene_expression (responded) of PHA
6) Confidence 0.12 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.92 Pain Relevance 0.03
NAL did not affect spontaneous IL-2 receptor expression and it moderately increased PHA-induced IL-2 receptor expression in most of the investigated persons.
Gene_expression (expression) of PHA-induced associated with narcan
7) Confidence 0.08 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2784786 Disease Relevance 0.37 Pain Relevance 0.71
Comparisons were made between untreated PBMC versus PBMC cultured in the presence of 1:100 dilutions of either MTB or CW, with and without PHA and PWM (Figure 5A-F).
Neg (without) Gene_expression (made) of PHA
8) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0 Pain Relevance 0.32
We have recently developed and characterized 2 novel murine monoclonal antibodies, anti-R23.1 and anti-R24.1, that recognize a 21 kDa cell surface molecule expressed by H/RS and ALCL cells, but not by phytohemagglutinin (PHA) activated CD30+ T lymphocytes [24].
Neg (not) Gene_expression (expressed) of PHA in T lymphocytes associated with anaplastic large cell lymphoma
9) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.10 Pain Relevance 0
However, it should be pointed out that PHA activated T cells contain intracellular CYB5B, but do not express it on the cell surface, since propidium iodide non-excluding (i.e. non viable and therefore naturally permeabilized due to loss of membrane integrity) PHA activated T cells bind anti-R23.1 mAb (unpublished observations).
Neg (not) Gene_expression (express) of PHA in T cells
10) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.10 Pain Relevance 0
Since we had previously reported that PHA-activated T cells do not express the 21 kDa protein at the cell surface [24], the detection of CYB5B in a PHA-induced T-lymphocyte cDNA library derived protein array may seem like a contradiction.
Gene_expression (detection) of PHA-induced in T-lymphocyte
11) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.05 Pain Relevance 0
This effect of PHA-induced proliferation was somewhat mirrored in the production of PHA-induced LT.
Gene_expression (production) of PHA
12) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0.10
In contrast, LT production by PHA-stimulated MNL was much greater in the n-3-supplemented group compared with placebo (Figure 5) and showed a significant and positive correlation with EPA erythrocyte content (Table 1, Figure 5).


Gene_expression (production) of PHA in erythrocyte
13) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0.05
In the tested panel, the T-cell mitogen PHA was found to be a potent inducer of survivin expression both by PBMC originating from RA patients (n = 3) and by PBMC from healthy controls (n = 6)
Gene_expression (found) of PHA in T-cell associated with rheumatoid arthritis
14) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.45 Pain Relevance 0.17
g/mL) in the presence of phytohemagglutinin L (PHA, 10 ?
Gene_expression (presence) of PHA
15) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0 Pain Relevance 0
For PHA as a stimulus, the 3 day IC50 of free MP was 0.029 ?
Gene_expression (0.029) of PHA
16) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0 Pain Relevance 0
For PHA as a stimulus, the IC50 of free MP was 0.021 ?
Gene_expression (0.021) of PHA
17) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.13 Pain Relevance 0.04
Proliferation of human lymphocytes was induced by exposing them to concanavilin A (Con A) or phytohemagglutinin L (PHA), two potent mitogens.
Gene_expression (exposing) of PHA in lymphocytes
18) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0 Pain Relevance 0
Thereby we used an immunospot assay for interferon-gamma (IFN-gamma) produced by lymph node mononuclear cells (MNC), which reflects number of memory T lymphocytes activated by antigen or lectin, in this experiment bovine peripheral nerve myelin (BPM) and phytohemagglutinin (PHA), respectively.
Gene_expression (reflects) of PHA in MNC
19) Confidence 0.05 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.40 Pain Relevance 0.44
Although experiments of this type are often cited as evidence that CHPK-mediated lamin A/C phosphorylation directly leads to lamina disruption, we note that they cannot rule out other mechanisms for lamina disruption upon CHPK expression or herpesvirus infection (such as lamin B or lamin receptor phosphorylation) in addition to or instead of lamin A/C phosphorylation.


Gene_expression (expression) of lamin receptor in lamina associated with herpes virus infection
20) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.10 Pain Relevance 0

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