INT1114

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Context Info
Confidence 0.80
First Reported 1975
Last Reported 2011
Negated 5
Speculated 5
Reported most in Abstract
Documents 748
Total Number 754
Disease Relevance 192.95
Pain Relevance 165.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreas 67
blood 27
pancreatic islets 24
plasma 21
beta cells 14
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 364 100.00 Very High Very High Very High
Enkephalin 226 100.00 Very High Very High Very High
Somatostatin 224 100.00 Very High Very High Very High
Bile 108 100.00 Very High Very High Very High
tolerance 685 99.96 Very High Very High Very High
Clonidine 537 99.92 Very High Very High Very High
antagonist 312 99.92 Very High Very High Very High
Dynorphin 163 99.92 Very High Very High Very High
Morphine 126 99.92 Very High Very High Very High
qutenza 123 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7809 100.00 Very High Very High Very High
Insulin Resistance 644 100.00 Very High Very High Very High
Stress 431 100.00 Very High Very High Very High
Hyperinsulinism 343 100.00 Very High Very High Very High
Apoptosis 263 100.00 Very High Very High Very High
Metabolic Syndrome 256 100.00 Very High Very High Very High
Obesity 612 99.98 Very High Very High Very High
Impaired Glucose Tolerance 690 99.96 Very High Very High Very High
Pressure And Volume Under Development 240 99.90 Very High Very High Very High
Hyperglycemia 499 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings suggest that, under anesthesia with ether, the endocrine pancreas is incapable of recognizing glucose as a specific stimulus to promote the release of insulin.
Localization (release) of insulin in endocrine pancreas associated with anesthesia
1) Confidence 0.80 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1282385 Disease Relevance 0.34 Pain Relevance 0.14
These results suggest that intestinal osmolality may enhance insulin release to intravenous glucose, but not to arginine in the rat.
Localization (release) of insulin
2) Confidence 0.80 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2117758 Disease Relevance 0 Pain Relevance 0.07
To elucidate the effect of intestinal osmolality on insulin secretion, we investigated insulin response to a subsequent intravenous infusion of glucose or arginine after intragastric or intraduodenal mannitol or NaCl instillation in the rat.
Localization (secretion) of insulin
3) Confidence 0.80 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2117758 Disease Relevance 0 Pain Relevance 0.09
Effect of intestinal osmolality on insulin secretion to subsequent intravenous glucose or arginine in the rat.
Localization (secretion) of insulin
4) Confidence 0.80 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 2117758 Disease Relevance 0 Pain Relevance 0.09
We conclude that immediately after hepatic dearterialization in rats with liver malignancies, glucose intolerance and impaired glucose-induced insulin secretion exist.
Localization (secretion) of insulin in liver associated with impaired glucose tolerance
5) Confidence 0.80 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2666752 Disease Relevance 0.48 Pain Relevance 0.06
Lithium exerts an inhibitory effect on glucose-induced insulin release.
Localization (release) of insulin
6) Confidence 0.80 Published 1987 Journal Diabetologia Section Abstract Doc Link 3556290 Disease Relevance 0 Pain Relevance 0.16
Thus, somatostatin does not appear to play a major regulatory role in the insulin secretion in the pancreas.
Localization (secretion) of insulin in pancreas associated with somatostatin
7) Confidence 0.80 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.45
DAMME had a dose-dependent effect on insulin secretion: low concentrations (10(-10) to 10(-8) mol/l) were stimulatory while high concentrations (10(-5) mol/l) were inhibitory in the presence of 8 mmol/l glucose.
Localization (secretion) of insulin
8) Confidence 0.80 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 0.97
Nalmefene given intragestrically attenuated glucose-stimulated increases in insulin release only in obese rats.
Localization (release) of insulin associated with obesity
9) Confidence 0.80 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 2947253 Disease Relevance 0.58 Pain Relevance 0.43
However, perfusions that were performed following an overnight fast demonstrated that the CNS is capable of modulating episodic insulin release.
Localization (release) of insulin in CNS associated with central nervous system
10) Confidence 0.80 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3279814 Disease Relevance 0 Pain Relevance 0.41
Morphine sulphate (5 X 10(-7) mol/l) also stimulated insulin release.
Localization (release) of insulin associated with morphine
11) Confidence 0.80 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 1.30
The insulin secretory response of perifused islets to enkephalins and morphine was rapid, corresponding to the first phase of glucose induced insulin release.
Localization (release) of insulin associated with enkephalin and morphine
12) Confidence 0.80 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 1.30
This study reports that insulin is secreted in an episodic manner in rats and that the characteristics of its release can be modified by the central nervous system (CNS) and state of satiety.
Localization (secreted) of insulin in CNS associated with central nervous system
13) Confidence 0.80 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3279814 Disease Relevance 0 Pain Relevance 0.24
The direct effect of lithium administration on plasma glucose levels and glucose-induced insulin release, and the role of opioid and amine systems in these effects were examined in rats.
Localization (release) of insulin in plasma associated with opioid
14) Confidence 0.80 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 2870599 Disease Relevance 0.15 Pain Relevance 0.32
The results suggest that the interaction of secreted endorphins with the sympathetic nervous system is the likely cause of the hyperglycaemia and the inhibition of the glucose-stimulated insulin release induced by lithium.
Localization (release) of insulin in sympathetic nervous system
15) Confidence 0.80 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 2870599 Disease Relevance 0.17 Pain Relevance 0.28
These peptides (3.95 X 10(-8) M), like morphine (3.95 X 10(-8) M), significantly inhibited the glucose-induced insulin secretion.
Localization (secretion) of insulin associated with morphine
16) Confidence 0.80 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.46
The inhibitory effect of rimorphin was attenuated by naloxone (1.2 X 10(-6) M) and phentolamine (10(-6) M), suggesting an involvement of adrenergic alpha receptors in the inhibition of glucose-induced insulin secretion mediated through specific opiate receptors.
Localization (secretion) of insulin associated with narcan and opiate
17) Confidence 0.80 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.48
The direct effects of an enkephalin analogue, (D-Ala2/MePhe4/Met/(O)-o1) enkephalin (DAMME), on insulin release from isolated islets of Langerhans of the rat have been investigated.
Localization (release) of insulin in islets of Langerhans associated with enkephalin
18) Confidence 0.80 Published 1980 Journal Diabetologia Section Abstract Doc Link 6998819 Disease Relevance 0 Pain Relevance 0.80
F-8-F-amide (at 1000 pM) inhibited stimulated insulin (controls: 100%; first phase: 26%, p less than 0.05%; second phase: 20%, p less than 0.05) and somatostatin release (controls: 100%; first phase: 14%, p less than 0.05; second phase: 29%, p less than 0.05).
Localization (release) of insulin associated with somatostatin
19) Confidence 0.80 Published 1990 Journal Neuropeptides Section Abstract Doc Link 1704109 Disease Relevance 0 Pain Relevance 0.12
A-18-F-amide (10, 100, 1000 pM) inhibited concentration dependently glucose (10 mM)- and arginine (10 mM)-induced insulin secretion from the isolated perfused rat pancreas during the first (controls: 100%; 10 pM: 114%; 100 pM: 63%, p less than 0.05; 1000 pM: 31%, p less than 0.05) and the second secretion phase (controls: 100%; 10 pM: 102%; 100 pM: 78%; 1000 pM: 27%, p less than 0.05).
Localization (secretion) of insulin in pancreas
20) Confidence 0.80 Published 1990 Journal Neuropeptides Section Abstract Doc Link 1704109 Disease Relevance 0 Pain Relevance 0.07

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