INT111401

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 134
Total Number 140
Disease Relevance 34.87
Pain Relevance 20.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 28
anterior 10
eye 6
bone marrow 6
lens 6
Tg(CAG-EGFP)D4Nagy (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 148 99.92 Very High Very High Very High
medulla 47 99.82 Very High Very High Very High
Nerve growth factor 20 99.82 Very High Very High Very High
Dorsal horn 129 99.76 Very High Very High Very High
nav1.8 112 99.72 Very High Very High Very High
Sciatic nerve 114 99.66 Very High Very High Very High
Action potential 252 99.60 Very High Very High Very High
imagery 455 99.48 Very High Very High Very High
Spinal cord 519 99.36 Very High Very High Very High
intrathecal 368 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 725 100.00 Very High Very High Very High
Salivary Gland Disease 15 100.00 Very High Very High Very High
Cancer 1343 99.92 Very High Very High Very High
Cytomegalovirus Infection 661 99.90 Very High Very High Very High
Cystitis 2 99.66 Very High Very High Very High
Ebola Virus Infection 55 99.56 Very High Very High Very High
Aging 52 99.52 Very High Very High Very High
Adenocarcinoma 1 99.42 Very High Very High Very High
Colitis 95 99.20 Very High Very High Very High
Generalized Anxiety Disorder 1 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas, increasing the injected viral titer to 1x108 pfu boosted GFP expression to a higher level (Fluorescence Grade at day 5=0.83 ±0.38, n=9; Figure 2B).
Positive_regulation (increasing) of Gene_expression (expression) of GFP
1) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.25 Pain Relevance 0
Again, treatment with anti-CD40L antibody augmented the expression of GFP.
Positive_regulation (augmented) of Gene_expression (expression) of GFP
2) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.29 Pain Relevance 0
We reduced this shortcoming by immunomodulation; treating the animals with the anti-CD40L antibody, which clearly increased the expression of GFP after IC injection, and significantly prolonged GFP expression after IVT injection to more than six weeks.
Positive_regulation (prolonged) of Gene_expression (expression) of GFP
3) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.11 Pain Relevance 0
Higher titer of the vector produced more prominent GFP expression.
Positive_regulation (prominent) of Gene_expression (expression) of GFP
4) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.15 Pain Relevance 0
We reduced this shortcoming by immunomodulation; treating the animals with the anti-CD40L antibody, which clearly increased the expression of GFP after IC injection, and significantly prolonged GFP expression after IVT injection to more than six weeks.
Positive_regulation (increased) of Gene_expression (expression) of GFP
5) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.11 Pain Relevance 0
Intraocular injections, both IC and IVT, of Ad5.CMV-GFP induced production of GFP and hence fluorescence in the anterior segment of the mouse eye.
Positive_regulation (induced) of Gene_expression (production) of GFP in eye associated with cytomegalovirus infection
6) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.15 Pain Relevance 0
For example, not much fluorescence in the anterior segment was observed at 5 and 43 days after IC injection of 1x107 pfu Ad5.CMV-GFP without anti-CD40L antibody treatment (Figure 5), while treatment with the anti-CD40L antibody enhanced the expression of GFP of the same injection regimen.
Positive_regulation (enhanced) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
7) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.22 Pain Relevance 0
Surprisingly, EGFP expression was detected in the lens after subretinal injection of AC-GFP but only nominal levels were achieved with injection of TFA-GFP.
Positive_regulation (detected) of Gene_expression (expression) of EGFP in lens
8) Confidence 0.52 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.06 Pain Relevance 0
Notably, LV-EGFP administration and EGFP overexpression in glial cells did neither modify glial activity, nor alter animal's nociceptive or locomotor behaviors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGFP in glial cells associated with nociception
9) Confidence 0.46 Published 2008 Journal J. Neurosci. Methods Section Abstract Doc Link 17949823 Disease Relevance 0.47 Pain Relevance 0.48
When the eGFP22 siRNA was electrotransferred (anti-GFP+EP), a significant decrease in the eGFP fluorescence of the tumor was observed within 48 hr following the treatment as observed by direct imaging on the animals (Figure 4).
Positive_regulation (electrotransferred) of Gene_expression (electrotransferred) of anti-GFP associated with cancer and imagery
10) Confidence 0.43 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.57 Pain Relevance 0.05
This procedure allowed observation of GFP expression in the same animal for several days.
Positive_regulation (observation) of Gene_expression (expression) of GFP
11) Confidence 0.43 Published 2008 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737239 Disease Relevance 0.22 Pain Relevance 0.18
Intraocular injection of Ad5.CMV-GFP induced titer-dependent expression of GFP in the anterior segment.
Positive_regulation (dependent) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
12) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.34 Pain Relevance 0
Immunomodulation of the animals by intraperitoneal injection of anti-CD40L antibody enhanced both the time and intensity of GFP expression.



Positive_regulation (enhanced) of Gene_expression (expression) of GFP
13) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.15 Pain Relevance 0
Treatment with anti-CD40L antibody increased fluorescence intensity after IC injection, and prolonged GFP expression in the IVT group.
Positive_regulation (prolonged) of Gene_expression (expression) of GFP
14) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.28 Pain Relevance 0
Intraocular injection of Ad5.CMV-GFP induced GFP expression in the mouse anterior segment, including the TM.
Positive_regulation (induced) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
15) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.15 Pain Relevance 0
This observation was confirmed by analysis of the data with three-way ANOVA, which indicated that GFP expression was significantly higher in the anti-CD40L than the no antibody group (p=0.013), significantly higher in the IVT than the IC group (p=0.003), and significantly higher in the high viral titer (1x108 pfu) than the low titer (1x107 pfu) group (p=0.010).
Positive_regulation (higher) of Gene_expression (expression) of GFP
16) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.18 Pain Relevance 0
Intraocular injection of Ad5.CMV-GFP induced titer-dependent expression of GFP in the anterior segment.
Positive_regulation (induced) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
17) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.35 Pain Relevance 0
Regardless of injection routes or titers of Ad5.CMV-GFP used, immunomodulation with treatment of anti-CD40L antibody always enhanced GFP expression in the mouse eye.
Positive_regulation (enhanced) of Gene_expression (expression) of GFP in eye associated with cytomegalovirus infection
18) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.42 Pain Relevance 0
We describe in this study that Ad5.CMV-GFP, when delivered by intraocular (IC or IVT) injection into the eye of the Balb/cJ mouse, led to GFP expression in the anterior segment structures.
Positive_regulation (led) of Gene_expression (expression) of GFP in anterior associated with cytomegalovirus infection
19) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267727 Disease Relevance 0.10 Pain Relevance 0
Three-Way ANOVA confirmed that GFP expression was significantly higher in the anti-CD40L than the no antibody group (p=0.013), significantly higher in the IVT than the IC group (p=0.003), and significantly higher in the high viral titer (1x108 pfu) than the low titer (1x107 pfu) group (p=0.010).
Positive_regulation (higher) of Gene_expression (expression) of GFP
20) Confidence 0.41 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267727 Disease Relevance 0.31 Pain Relevance 0

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