INT111404

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.49
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 2
astrocytes 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 8 99.84 Very High Very High Very High
Morphine 12 99.52 Very High Very High Very High
tolerance 4 99.52 Very High Very High Very High
Glutamate 26 99.36 Very High Very High Very High
Action potential 9 98.84 Very High Very High Very High
central sensitization 4 96.16 Very High Very High Very High
nMDA receptor 59 94.44 High High
qutenza 3 91.76 High High
cytokine 11 91.12 High High
Spinal cord 8 90.32 High High
Disease Link Frequency Relevance Heat
Injury 12 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 92.16 High High
Infection 34 91.84 High High
Neuropathic Pain 85 90.28 High High
Pain 7 88.56 High High
Nervous System Injury 5 87.68 High High
Urological Neuroanatomy 1 87.64 High High
Channelopathies 1 77.68 Quite High
Death 16 77.04 Quite High
Hyperalgesia 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-administration of LY274614 (s.c. at 24 mg/kg/24 h via an osmotic pump) not only attenuated the development of morphine tolerance but also prevented the changes in the NR1 mRNA levels induced by chronic morphine administration.
Regulation (changes) of Positive_regulation (induced) of NR1 mRNA associated with tolerance and morphine
1) Confidence 0.56 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.09 Pain Relevance 1.81
Thus, we next examined whether the depletion of CSPAs with resiniferatoxin (RTX) modified the change of spinal NR1 and pNR1 expression induced by CCI.
Spec (whether) Regulation (change) of Spec (whether) Positive_regulation (induced) of NR1 in spinal associated with eae
2) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.99 Pain Relevance 0.98
Therefore, inhibiting astrocytic activation (e.g. with LAA in our study) could down-regulate activation of NMDAR via preventing glutamate release from astrocytes.
Regulation (regulate) of Positive_regulation (activation) of NMDAR in astrocytes associated with glutamate
3) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.41 Pain Relevance 0.83
Real-time polymerase chain reaction analysis showed that the mRNA expression profiles for NR1, NR2A, and NR2B subunits were not significantly changed by 10 ┬ÁM UCB treatment for 48 h (p<0.05) (Figure 5).
Neg (not) Regulation (changed) of Positive_regulation (profiles) of NR1
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.23 Pain Relevance 0.40
For both pathways, the potentiation observed was dependent on NMDAR activation, as has been reported previously [49].
Regulation (dependent) of Positive_regulation (activation) of NMDAR
5) Confidence 0.11 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.11 Pain Relevance 0
Hence, modulation of Kv channels by some of these compounds could significantly affect NMDAR activation, membrane excitability, and action potential propagation.
Regulation (affect) of Positive_regulation (activation) of NMDAR associated with action potential
6) Confidence 0.02 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.67 Pain Relevance 0.29

General Comments

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