INT111405

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 4 99.80 Very High Very High Very High
Morphine 11 99.60 Very High Very High Very High
Spinal cord 3 90.88 High High
nMDA receptor 4 89.80 High High
Periaqueductal grey 1 88.20 High High
Locus ceruleus 1 87.36 High High
Thalamus 1 82.32 Quite High
Raphe magnus 1 81.52 Quite High
Dorsal horn 1 79.48 Quite High
antinociception 2 76.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-administration of LY274614 (s.c. at 24 mg/kg/24 h via an osmotic pump) not only attenuated the development of morphine tolerance but also prevented the changes in the NR1 mRNA levels induced by chronic morphine administration.
Negative_regulation (prevented) of Regulation (changes) of NR1 mRNA associated with tolerance and morphine
1) Confidence 0.54 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.09 Pain Relevance 1.81

General Comments

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