INT11141

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 3.85
Pain Relevance 12.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
PVN 8
neurons 6
Plasma 2
impression 2
jaw 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 116 100.00 Very High Very High Very High
amygdala 19 100.00 Very High Very High Very High
intrathecal 16 100.00 Very High Very High Very High
antinociception 9 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
dexamethasone 28 99.98 Very High Very High Very High
Clonidine 4 99.84 Very High Very High Very High
antagonist 43 99.76 Very High Very High Very High
Morphine 44 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 132 100.00 Very High Very High Very High
Nociception 7 99.96 Very High Very High Very High
Cv Unclassified Under Development 2 99.68 Very High Very High Very High
Hypertension 23 98.88 Very High Very High Very High
Endotoxemia 2 97.36 Very High Very High Very High
Chronic Renal Failure 124 97.12 Very High Very High Very High
Heart Rate Under Development 4 96.44 Very High Very High Very High
Stress 30 95.28 Very High Very High Very High
INFLAMMATION 33 93.44 High High
Convulsion 6 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone treatment, in contrast, significantly decreased AVP mRNA expression levels in the PVN, but this inhibitory action was abolished in the presence of DRB or the sodium channel blocker tetrodotoxin (TTX).
Negative_regulation (decreased) of Gene_expression (expression) of AVP mRNA in PVN associated with tetrodotoxin, sodium channel and dexamethasone
1) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.57
However, when the hypothalamic slices were treated with forskolin, dexamethasone decreased AVP mRNA expression even in the presence of DRB and/or TTX.
Negative_regulation (decreased) of Gene_expression (expression) of AVP mRNA associated with tetrodotoxin and dexamethasone
2) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.65
Basal vasopressin mRNA expression in the paraventricular and supraoptic nuclei decreased slightly 6 h after LPS injection, without changes in vasopressin transcription as indicated by vasopressin heteronuclear (hn) RNA levels.
Negative_regulation (decreased) of Gene_expression (expression) of vasopressin mRNA
3) Confidence 0.58 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535156 Disease Relevance 0.10 Pain Relevance 0.07
The data show that endotoxemia causes morphological and functional alterations of the hypothalamic neurohypophyseal system, resulting in facilitation rather than inhibition of vasopressin synthesis, and secretion in response to osmotic stimulation.
Negative_regulation (inhibition) of Gene_expression (synthesis) of vasopressin associated with endotoxemia
4) Confidence 0.58 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12535156 Disease Relevance 0.15 Pain Relevance 0.07
In conclusion, present results show that, in addition to modifications in corticosterone secretion and in noradrenaline turnover, chronic morphine administration produces a reduction in the synthesis of CRF and AVP.
Negative_regulation (reduction) of Gene_expression (synthesis) of AVP associated with noradrenaline and morphine
5) Confidence 0.57 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.74
Furthermore, AVP hnRNA expression induced by forskolin was attenuated by dexamethasone treatment in the presence of TTX.
Negative_regulation (attenuated) of Gene_expression (expression) of AVP hnRNA associated with tetrodotoxin and dexamethasone
6) Confidence 0.43 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.66
Dexamethasone treatment, in contrast, significantly decreased AVP mRNA expression levels in the PVN, but this inhibitory action was abolished in the presence of DRB or the sodium channel blocker tetrodotoxin (TTX).
Negative_regulation (abolished) of Gene_expression (expression) of AVP mRNA in PVN associated with tetrodotoxin, sodium channel and dexamethasone
7) Confidence 0.43 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.60
In addition, vasopressin mRNA expression, probably representing axonal mRNA, was detected over the hypothalamopituitary tract.
Negative_regulation (detected) of Gene_expression (expression) of vasopressin mRNA
8) Confidence 0.42 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10404247 Disease Relevance 0.09 Pain Relevance 0.35
Similarly, there was a decrease in intensity of AVP mRNA expression in the parvocellular and magnocellular neurones of the PVN in the morphine-group injected with saline, suggesting a decreased synthesis of AVP in these neurones.
Negative_regulation (decreased) of Gene_expression (synthesis) of AVP in PVN associated with morphine
9) Confidence 0.42 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.95
Microinjection of arginine vasopressin into the central nucleus of amygdala suppressed nociceptive jaw opening reflex in freely moving rats.
Negative_regulation (suppressed) of Gene_expression (Microinjection) of arginine vasopressin in jaw associated with nociception, narcan and amygdala
10) Confidence 0.41 Published 2001 Journal Brain Res. Bull. Section Title Doc Link 11427346 Disease Relevance 0.10 Pain Relevance 1.04
In parallel with the decrease in the expression of CRF and AVP mRNAs in the PVN, there was a pronounced decrease in noradrenaline turnover and in the release of corticosterone in the morphine-pelleted rats.
Negative_regulation (decrease) of Gene_expression (expression) of AVP in PVN associated with noradrenaline and morphine
11) Confidence 0.41 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.95
Coronal hypothalamic sections were used for evaluation of Fos, AVP and OT expression by immunohistochemistry.
Negative_regulation (evaluation) of Gene_expression (expression) of AVP
12) Confidence 0.41 Published 2007 Journal Stress Section Abstract Doc Link 17853060 Disease Relevance 0.32 Pain Relevance 0.10
This finding was similar to Herman's study [9,30], in which a marked loss of magnocellular AVP-containing neurons was induced after neurohypophysectomy in conjunction with chronic vasopressin agonist treatment.
Negative_regulation (loss) of Gene_expression (neurons) of AVP-containing in neurons associated with agonist
13) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2442085 Disease Relevance 0.27 Pain Relevance 0.05
These studies showed that IT administration of a V1-specific vasopressin antagonist completely blocked the antinociception, scratching behavior, and motor suppression produced by 25 ng IT vasopressin.
Negative_regulation (blocked) of Gene_expression (produced) of IT vasopressin associated with antinociception, antagonist and intrathecal
14) Confidence 0.35 Published 1992 Journal Peptides Section Abstract Doc Link 1535707 Disease Relevance 0.09 Pain Relevance 1.28
The initial pressor effect was significantly greater in the SHR, Plasma vasopressin levels in SHR were depressed relative to both untreated hypertensive rats and animals given vehicle control injections.
Negative_regulation (depressed) of Gene_expression (levels) of vasopressin in Plasma associated with hypertension
15) Confidence 0.34 Published 1981 Journal Hypertension Section Abstract Doc Link 7309204 Disease Relevance 0.44 Pain Relevance 0.85
The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors. 3.
Negative_regulation (inhibition) of Gene_expression (produced) of vas in vas deferens associated with clonidine
16) Confidence 0.27 Published 1981 Journal J Pharmacol Section Abstract Doc Link 6111626 Disease Relevance 0 Pain Relevance 0.47
In depressed patients, both synthesis and release of AVP in the SCN is reduced, which leads to an impaired functional activity of the circadian clock [187], although there was an increase in the number of AVP-immunoreactive neurons.
Negative_regulation (reduced) of Gene_expression (synthesis) of AVP in neurons
17) Confidence 0.20 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.06 Pain Relevance 0.04
Reduction of AVP neurons of the SCN has been reported to eliminate or reduce the amplitude of many rhythms studied.
Negative_regulation (Reduction) of Gene_expression (neurons) of AVP in neurons
18) Confidence 0.13 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0
Concentrations of vasopressin and oxytocin decreased in response to both osmotic stimuli and treatment with T2 toxin, but the decrease was greater with osmotic stimulations.
Negative_regulation (decreased) of Gene_expression (Concentrations) of vasopressin
19) Confidence 0.10 Published 1985 Journal Science Section Abstract Doc Link 2858918 Disease Relevance 0 Pain Relevance 1.07
Thus, these studies all provide firm evidence for the decreased of vasopressin-regulated water channel AQP2 expression and the significant defects in the collecting duct of the kidneys from CRF.
Negative_regulation (decreased) of Gene_expression (expression) of vasopressin in duct associated with chronic renal failure
20) Confidence 0.06 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.81 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox