INT111422

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
brain structures 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 8 100.00 Very High Very High Very High
antinociception 4 100.00 Very High Very High Very High
Pain 10 99.92 Very High Very High Very High
Endocannabinoid 3 99.92 Very High Very High Very High
cocaine 6 99.84 Very High Very High Very High
nMDA receptor antagonist 3 99.20 Very High Very High Very High
gABA 18 98.12 Very High Very High Very High
antagonist 8 93.48 High High
nMDA receptor 3 92.76 High High
Glutamate 1 92.04 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 97.00 Very High Very High Very High
Ganglion Cysts 76 84.80 Quite High
Pain 8 81.28 Quite High
Bordatella Infection 9 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that deletion of MOR and DOR causes alterations in cannabinoid receptor levels and functional activity in specific brain structures, which could explain some of the functional interactions observed between these two neuronal systems.
Positive_regulation (causes) of Regulation (alterations) of cannabinoid receptor in brain structures associated with cannabinoid receptor
1) Confidence 0.03 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622180 Disease Relevance 0.33 Pain Relevance 0.45
The effect of cannabinoid receptor antagonism with SR141716A on antinociception induced by cocaine and the NMDA receptor antagonist, MK-801.
Positive_regulation (induced) of Regulation (effect) of cannabinoid receptor associated with endocannabinoid, antinociception, nmda receptor antagonist, cannabinoid receptor and cocaine
2) Confidence 0.01 Published 2003 Journal Brain Res. Bull. Section Title Doc Link 12832001 Disease Relevance 0 Pain Relevance 1.41
Our results are not explained by these findings but PKA has also been implicated in presynaptic inhibition of GABA release [38], large conductance calcium – and voltage-activated K+ channel activity [39] and cannabinoid receptor mediated modulation of ion channels [40].
Positive_regulation (mediated) of Regulation (modulation) of cannabinoid receptor associated with gaba and cannabinoid receptor
3) Confidence 0.00 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC514605 Disease Relevance 0.23 Pain Relevance 0.89

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox