INT111437

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MCC) plasma membrane (MCC) nucleus (MCC)
cytoplasm (MCC)
MCC (Homo sapiens)
MCC - Q67L (1) MCC - K23R (1)
Pain Link Frequency Relevance Heat
Neuropathic pain 52 98.42 Very High Very High Very High
amygdala 1 93.44 High High
Pain 81 81.52 Quite High
Chronic pancreatitis 1 80.24 Quite High
Cluster headache 1 74.08 Quite High
central sensitization 1 23.36 Low Low
Lasting pain 25 17.88 Low Low
insula 27 16.00 Low Low
primary somatosensory cortex 29 5.00 Very Low Very Low Very Low
Somatosensory cortex 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 83 99.36 Very High Very High Very High
Neuropathic Pain 71 98.42 Very High Very High Very High
Anxiety Disorder 2 97.54 Very High Very High Very High
Nociception 1 86.00 High High
Pain 103 81.52 Quite High
Pancreatitis 1 80.24 Quite High
Cluster Headache 1 74.08 Quite High
Cognitive Disorder 4 36.04 Quite Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The physiological activator enteropeptidase activated the D19A mutant normally, activated the D22G mutant very poorly, and stimulated activation of the K23R mutant.
Positive_regulation (activation) of K23R mutant (K23R)
1) Confidence 0.05 Published 2003 Journal Mol. Biol. Evol. Section Abstract Doc Link 12832630 Disease Relevance 0.16 Pain Relevance 0.08
Our data demonstrate that despite accelerated nucleotide exchange and a marked increase in the active fraction similar to the Q67L mutant (Fig. 3), Rab7 disease mutants have normal subcellular localization and only subtle defects in membrane extraction (Fig. 5).
Positive_regulation (increase) of Q67L mutant (Q67L) associated with disease
2) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.48 Pain Relevance 0
As such it may be involved in fear-avoidance role of the perception of the TNP, and although there was no colocalized BOLD activation it was adjacent to the pMCC activation.
Positive_regulation (activation) of pMCC associated with anxiety disorder and neuropathic pain
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561059 Disease Relevance 0.84 Pain Relevance 0.71

General Comments

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