INT111451

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 18.81
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADIPOQ) extracellular space (ADIPOQ) extracellular region (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plasma 2
blood 1
poly 1
platelet 1
upper 1
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 10 99.96 Very High Very High Very High
Inflammation 95 99.50 Very High Very High Very High
antidepressant 46 96.80 Very High Very High Very High
cytokine 28 95.20 Very High Very High Very High
Angina 38 89.44 High High
beta blocker 7 87.04 High High
chemokine 3 82.36 Quite High
agonist 5 74.96 Quite High
positron emission tomography 2 63.92 Quite High
Inflammatory marker 7 62.16 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 158 100.00 Very High Very High Very High
Aging 28 100.00 Very High Very High Very High
Obesity 514 99.84 Very High Very High Very High
INFLAMMATION 111 99.50 Very High Very High Very High
Polycystic Ovary Syndrome 20 99.48 Very High Very High Very High
Weight Loss 125 99.22 Very High Very High Very High
Coronary Artery Disease 117 99.20 Very High Very High Very High
Diabetes Mellitus 246 98.92 Very High Very High Very High
Insulin Resistance 208 98.08 Very High Very High Very High
Metabolic Syndrome 195 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
'Adiponectin paradox' 5, namely a high adiponectin level being a predictor of
   mortality has been repeatedly observed in patients with chronic heart failure 6, particularly in subjects with normal body mass index (BMI)
    6, suggesting that the prognostic significance of
   adiponectin in this condition is affected by BMI. 
Regulation (affected) of adiponectin in body associated with obesity and myocardial infarction
1) Confidence 0.56 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.28 Pain Relevance 0.22
However, prior studies have also shown conflicting results with respect to the age-related changes in adiponectin concentrations (42).
Regulation (changes) of adiponectin
2) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 0.70 Pain Relevance 0.18
CONCLUSIONS: Chronic pancreatitis in humans (a) is associated with the decrease in serum leptin and insulin concentrations, (b) does not affect serum adiponectin concentration but increases serum adiponectin/leptin concentration ratio, and (c) alters the interrelationship between serum adiponectin and insulin concentrations.
Neg (not) Regulation (affect) of adiponectin
3) Confidence 0.41 Published 2008 Journal Pancreas Section Body Doc Link 18376301 Disease Relevance 0.06 Pain Relevance 0
There is an ongoing debate regarding adiponectin's significance for CAD.
Regulation (regarding) of adiponectin associated with coronary artery disease
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.93 Pain Relevance 0.11
In the present study, changes seen in the plasma lipid profiles of subjects who took DNJ-rich mulberry leaf extract appeared to be uncorrelated with changes in adiponectin and leptin levels.
Regulation (changes) of adiponectin in leaf
5) Confidence 0.38 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.24 Pain Relevance 0
Changes in adiponectin, leptin, and ApoB over time
Regulation (Changes) of adiponectin
6) Confidence 0.38 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.16 Pain Relevance 0
The changes in adiponectin, leptin, and ApoB over time are shown in TableĀ 6.
Regulation (changes) of adiponectin
7) Confidence 0.38 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935155 Disease Relevance 0.16 Pain Relevance 0
A better understanding of the effects of alterations in the gelatin molecular weight and type on the formation and properties of the gelatin-HydroThane IPN should facilitate the development of promising composite biomaterials for wound dressing applications.
Regulation (effects) of gelatin-HydroThane associated with ipn and injury
8) Confidence 0.38 Published 2008 Journal J Mater Sci Mater Med Section Abstract Doc Link 17665128 Disease Relevance 0.45 Pain Relevance 0.35
Only HDL-cholesterol, triglycerides, apo B, fasting insulin, HOMA index,
   SHBG, CRP and adiponectin concentrations were significantly different in the bottom tertile
   (lean individuals) from those in the other tertiles. 
Regulation (different) of adiponectin associated with disorder of lipid metabolism
9) Confidence 0.36 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.52 Pain Relevance 0
In addition, we also examined the effect of aging on adiponectin concentrations.
Spec (examined) Regulation (effect) of adiponectin associated with aging
10) Confidence 0.35 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 0.65 Pain Relevance 0.17
To determine whether storage conditions may have affected adiponectin levels, adiponectin concentrations in aliquots stored for 21 and 33 months at ?
Spec (may) Regulation (affected) of adiponectin
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.68 Pain Relevance 0
To determine whether storage conditions may have affected adiponectin levels, adiponectin concentrations in aliquots stored for 21 and 33 months at ?
Regulation (concentrations) of adiponectin
12) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.68 Pain Relevance 0
To determine whether storage conditions may have affected adiponectin levels, adiponectin concentrations in aliquots stored for 21 and 33 months at ?
Regulation (concentrations) of adiponectin
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.67 Pain Relevance 0
Storage conditions of blood samples (e.g. storage time and temperature) were suggested to alter adiponectin levels [43], [44].
Regulation (alter) of adiponectin in blood
14) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 0.54 Pain Relevance 0
Although some authors [25] believed that the changed adiponectin levels are associated with presence of risk factors of metabolic syndrome but our findings in line of other studies emphasis that its deficiency may lead to thrombus formation and platelet aggregation [15].
Regulation (changed) of adiponectin in platelet associated with metabolic syndrome and thrombosis
15) Confidence 0.27 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2694800 Disease Relevance 1.79 Pain Relevance 0.19
Interestingly, our result demonstrated the plasma IL-6 was significantly elevated and independent of weight change, adiponectin and TNF-?
Regulation (change) of adiponectin in plasma
16) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 0.71 Pain Relevance 0.51
At 72 h after induction of differentiation, the medium was changed and treated with either mammalian globular adiponectin for 48 h (R&D Systems, Minneapolis, MN, USA) or with a nitric oxide donorĀ— 50 ?
Regulation (globular) of adiponectin
17) Confidence 0.23 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.06 Pain Relevance 0
Discrimination analyses and construction of receiver operating characteristic curves of both the uni- and multivariate models were performed to assess the predictive values of HOMA and adiponectin alone and in combination with the EuroSCORE.
Regulation (values) of adiponectin
18) Confidence 0.16 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.60 Pain Relevance 0
Predictive values of HOMA, adiponectin and the EuroSCORE
Regulation (values) of adiponectin
19) Confidence 0.16 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.53 Pain Relevance 0
For insulin resistance the upper quartile was HOMA index levels above 2.6, and for adiponectin the upper quartile was adiponectin values above 11.7 mg/liter.
Regulation (values) of adiponectin in upper associated with insulin resistance
20) Confidence 0.14 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC3009968 Disease Relevance 0.34 Pain Relevance 0.04

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