INT11146

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Context Info
Confidence 0.51
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 10.33
Pain Relevance 8.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Wrist 2
Forearm 1
nerve 1
skin 1
CTS (Homo sapiens)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 198 100.00 Very High Very High Very High
Pain 34 100.00 Very High Very High Very High
cytokine 1 92.44 High High
Inflammation 4 92.04 High High
Peripheral nervous system 6 91.44 High High
agonist 2 85.48 High High
peripheral neuropathy 1 83.52 Quite High
antagonist 3 81.32 Quite High
gABA 4 80.88 Quite High
ischemia 3 79.32 Quite High
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 214 100.00 Very High Very High Very High
Pain 31 100.00 Very High Very High Very High
Diabetes Mellitus 10 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 98.78 Very High Very High Very High
Stress 3 98.54 Very High Very High Very High
Brain Injury 2 97.60 Very High Very High Very High
Renal Disease 1 97.44 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.88 Very High Very High Very High
Pressure And Volume Under Development 3 96.44 Very High Very High Very High
Adhesions 4 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During ischaemia there were decreases in axonal threshold, with less overall reduction in CTS patients when compared with controls.
Negative_regulation (reduction) of CTS associated with cv unclassified under development and carpal tunnel syndrome
1) Confidence 0.51 Published 2009 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 19909483 Disease Relevance 1.24 Pain Relevance 0.77
Fifty-one (73.9%) workers in the experimental group had findings compatible to the NIOSH definition of Work-Related CTS.
Negative_regulation (definition) of CTS associated with carpal tunnel syndrome
2) Confidence 0.42 Published 2004 Journal J Occup Health Section Abstract Doc Link 15215667 Disease Relevance 0.41 Pain Relevance 0.41
We conclude that although steroid injections are safe and effective for temporary relief of CTS, most patients will eventually require surgery for long-term control of their symptoms.
Negative_regulation (relief) of CTS associated with carpal tunnel syndrome
3) Confidence 0.37 Published 2004 Journal Muscle Nerve Section Abstract Doc Link 14694502 Disease Relevance 0.49 Pain Relevance 0.53
Simulated compression of the nerve in laboratory animals also confirms these findings, further corroborating the pathophysiology and suggesting means of preventing idiopathic CTS.
Negative_regulation (preventing) of CTS in nerve associated with carpal tunnel syndrome
4) Confidence 0.37 Published 2005 Journal Microsurgery Section Abstract Doc Link 15481038 Disease Relevance 0.76 Pain Relevance 0.44
Modification of the work environment to decrease occupational stresses and minimize awkward postures and positions is an effective strategy to prevent CTS by improving the worker-job interplay.
Negative_regulation (prevent) of CTS associated with stress and carpal tunnel syndrome
5) Confidence 0.37 Published 1992 Journal AAOHN J Section Abstract Doc Link 1536686 Disease Relevance 0.59 Pain Relevance 0.57
BACKGROUND: This surveillance study was undertaken to target efforts to prevent work-related carpal tunnel syndrome (WR-CTS) and to assess physician case-reports as a source of surveillance data.
Negative_regulation (prevent) of WR-CTS associated with carpal tunnel syndrome
6) Confidence 0.37 Published 2001 Journal Am. J. Ind. Med. Section Abstract Doc Link 11148016 Disease Relevance 0.17 Pain Relevance 0.17
At 1 year, local steroid injection is as effective as surgical decompression for the symptomatic relief of CTS.


Negative_regulation (relief) of CTS
7) Confidence 0.37 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15692981 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Over the short term, local steroid injection is better than surgical decompression for the symptomatic relief of CTS.
Negative_regulation (relief) of CTS
8) Confidence 0.37 Published 2005 Journal Arthritis Rheum. Section Body Doc Link 15692981 Disease Relevance 0 Pain Relevance 0
In order to evaluate if "dropping objects" was an index of more severe CTS impairment, we compared the severity measures between the patients with and without this condition.
Negative_regulation (impairment) of CTS associated with carpal tunnel syndrome
9) Confidence 0.37 Published 2010 Journal Neurol. Sci. Section Abstract Doc Link 20217442 Disease Relevance 0.51 Pain Relevance 0.65
In conclusion, patients with low-grade CTS experience skin temperature reduction, presumably caused by increased sweating as opposed to a generally suspected vasoconstriction.
Negative_regulation (reduction) of CTS in skin associated with carpal tunnel syndrome and increased venous pressure under development
10) Confidence 0.37 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15679703 Disease Relevance 0.47 Pain Relevance 0.40
This paper directs particular attention to prevention of CTS during pregnancy and discusses changes in symptoms during the course of treatment of CTS with vitamin B6.
Negative_regulation (prevention) of CTS associated with carpal tunnel syndrome
11) Confidence 0.37 Published 1987 Journal South. Med. J. Section Abstract Doc Link 3603108 Disease Relevance 0.46 Pain Relevance 0.46
Of the 130 slight CTS not surgically treated, clinical manifestations persisted for one year in 118, 17 of which have normal electrophysiological parameters.
Negative_regulation (persisted) of CTS associated with carpal tunnel syndrome
12) Confidence 0.37 Published 1998 Journal Neurologia Section Abstract Doc Link 9578673 Disease Relevance 0.70 Pain Relevance 0.69
These data may be useful in the design of tasks and hand tools in the management and prevention of CTS.
Negative_regulation (prevention) of CTS associated with carpal tunnel syndrome
13) Confidence 0.37 Published 1998 Journal J Hand Surg Am Section Abstract Doc Link 9523952 Disease Relevance 0.54 Pain Relevance 0.24
50 weeks versus > 50 weeks, non-dominant versus dominant side affected, unilateral versus bilateral CTS complaints, no previous episodes versus previous episodes of CTS complaints, preference for surgery versus splinting versus no preference, baseline severity of the main complaint ?
Negative_regulation (episodes) of CTS
14) Confidence 0.37 Published 2001 Journal BMC Neurol Section Body Doc Link PMC64540 Disease Relevance 0 Pain Relevance 0.03
Rehabilitation was ineffective in diabetic CTS.
Negative_regulation (ineffective) of CTS associated with diabetes mellitus and carpal tunnel syndrome
15) Confidence 0.37 Published 2009 Journal J Clin Neurophysiol Section Abstract Doc Link 19952571 Disease Relevance 0.75 Pain Relevance 0.48
The main limitation of the study was the lack of exhaustiveness of the surveillance network of neurologists, which led to an underestimation of the incidence of CTS.12 28
Negative_regulation (underestimation) of CTS associated with carpal tunnel syndrome
16) Confidence 0.34 Published 2009 Journal Occupational and Environmental Medicine Section Body Doc Link PMC2693672 Disease Relevance 0.28 Pain Relevance 0.28
Wrist splinting or other prophylactic treatments beginning soon after stroke might help to prevent CTS.


Negative_regulation (prevent) of CTS in Wrist
17) Confidence 0.32 Published 1999 Journal Stroke Section Body Doc Link 9933281 Disease Relevance 0 Pain Relevance 0
Median distal motor latency to MTM is frequently abnormal in CTS showing similar sensitivity and specificity to 2-LINT and median distal sensory latency.
Negative_regulation (abnormal) of CTS
18) Confidence 0.31 Published 2007 Journal Clin Neurophysiol Section Body Doc Link 17307031 Disease Relevance 0 Pain Relevance 0
Nine joules of energy over five points (7-15 treatments) reversed CTS in 77% of cases with three-fold normalization of CMAP.
Negative_regulation (reversed) of CTS
19) Confidence 0.31 Published 1997 Journal Muscle Nerve Section Abstract Doc Link 9236795 Disease Relevance 0.07 Pain Relevance 0.20
In addition, the direct Forearm-mix CV was similar in CTS and controls; however, there was a significant decrease in indirect forearm-mix CV only in the CTS.
Negative_regulation (decrease) of CTS in Forearm associated with carpal tunnel syndrome
20) Confidence 0.31 Published 2008 Journal J Clin Neurophysiol Section Abstract Doc Link 18997631 Disease Relevance 0.62 Pain Relevance 0.63

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