INT111461

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 21.08
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
sputum 1
bile 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 109 99.08 Very High Very High Very High
spinal inflammation 62 98.92 Very High Very High Very High
Arthritis 72 98.60 Very High Very High Very High
Bile 1 94.92 High High
agonist 3 93.40 High High
antagonist 25 92.92 High High
alcohol 4 89.40 High High
fibrosis 69 88.36 High High
monoamine 13 84.72 Quite High
palliative 36 81.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 117 99.96 Very High Very High Very High
Anaemia 1999 99.58 Very High Very High Very High
Heart Disease 10 99.16 Very High Very High Very High
Rheumatoid Arthritis 109 99.08 Very High Very High Very High
Cancer 1222 99.06 Very High Very High Very High
Schizophrenia 13 99.00 Very High Very High Very High
Low Back Pain 66 98.92 Very High Very High Very High
Death 26 98.84 Very High Very High Very High
Seronegative Spondarthritis 62 98.60 Very High Very High Very High
Lymphatic System Cancer 423 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was interesting to note that Hb level elevated above the normal values with both plant extracts plus lead.
Positive_regulation (elevated) of Hb
1) Confidence 0.38 Published 2010 Journal Toxicology International Section Body Doc Link PMC2964740 Disease Relevance 0 Pain Relevance 0
All patients do not respond, and all patients who respond with an increase in Hb do not experience QoL gains.
Positive_regulation (increase) of Hb
2) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.78 Pain Relevance 0.07
It is a matter of controversy whether an increase in Hb levels is a goal in itself in these patients.
Spec (whether) Positive_regulation (increase) of Hb
3) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.92 Pain Relevance 0.07
Therefore, the most obvious effect of increasing Hb levels from a clinical perspective, the improvement of QoL, has come into focus.


Positive_regulation (increasing) of Hb
4) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.93 Pain Relevance 0
Transfusion therapy usually does not aim at keeping the Hb level higher than about 10 g/dl, and recent studies show important gains in QoL when Hb is increased from this level to above12 g/dl.



Positive_regulation (increased) of Hb
5) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.74 Pain Relevance 0.08
In cancer anemia, the first randomized study showing an increased Hb response with IV iron was published in 2004 (Auerbach et al 2004).
Positive_regulation (increased) of Hb associated with anaemia and cancer
6) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.95 Pain Relevance 0
An increase in Hb should be expected within 6 weeks.
Positive_regulation (increase) of Hb
7) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.59 Pain Relevance 0.05
Meta-analysis of treatment studies in mixed cancer populations have shown not only that ESA treatment reduces transfusions and increases Hb levels (Seidenfeld et al 2001), but also has a positive effect on QoL (Glaspy et al 1997; Demetri et al 1998; Crawford et al 2002; Gabrilove et al 2001; Littlewood et al 2001; Quirt et al 2001; Cella 2002; Fallowfield et al 2002; Cella et al 2003a; Vansteenkiste and Wauters 2005; Witzig et al 2005).
Positive_regulation (increases) of Hb associated with cancer
8) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.48 Pain Relevance 0.04
The Hb level increased in the “early” treatment group and decreased in the “late” group (p < 0.0001).
Positive_regulation (increased) of Hb
9) Confidence 0.38 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.46 Pain Relevance 0
Generation of HB-EGF KO mice using a gene targeting Cre-loxP and PCR
Positive_regulation (Generation) of HB-EGF associated with targeted disruption
10) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.50 Pain Relevance 0.04
Response to ESA therapy has generally been defined as an increase in Hb of >2 g/dl, and response rates vary between investigations, depending on the profile of the study populations.
Positive_regulation (increase) of Hb
11) Confidence 0.33 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.21 Pain Relevance 0
Still, Hb increase after 4–6 weeks is the only reliable response indicator.


Positive_regulation (increase) of Hb
12) Confidence 0.33 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.34 Pain Relevance 0
From measurements of HbO2, Hb, and HbT concentrations (the latter proportional to blood volume) and blood flow, the rate of oxidative metabolism can be indirectly assessed as the product of the rate of blood flow and relative oxygen extraction fraction (OEF).
Positive_regulation (measurements) of Hb in blood
13) Confidence 0.33 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0 Pain Relevance 0
From measurements of HbO2, Hb, and HbT concentrations (the latter proportional to blood volume) and blood flow, the rate of oxidative metabolism can be indirectly assessed as the product of the rate of blood flow and relative oxygen extraction fraction (OEF).
Positive_regulation (measurements) of HbT in blood
14) Confidence 0.33 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0 Pain Relevance 0
From measurements of HbO2, Hb, and HbT concentrations (the latter proportional to blood volume) and blood flow, the rate of oxidative metabolism can be indirectly assessed as the product of the rate of blood flow and relative oxygen extraction fraction (OEF).
Positive_regulation (measurements) of HbO2 in blood
15) Confidence 0.33 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018079 Disease Relevance 0 Pain Relevance 0
All patients with Tsat < 20% in the IV iron group responded with a Hb increase >2 g/dl.
Positive_regulation (increase) of Hb
16) Confidence 0.28 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.28 Pain Relevance 0
In a study of 349 myeloma and lymphoma patients, Österborg and colleagues (2002) confirmed a QoL gain in the ESA-treated patients and a correlation between Hb increase and QoL improvement.


Positive_regulation (increase) of Hb associated with lymphatic system cancer
17) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.68 Pain Relevance 0
The efficacy of ESA treatment in increasing Hb levels was shown in a randomized, placebo-controlled study in nonmyeloid malignancies, where the responses rates were 67% vs 27% in the epoetin beta and placebo groups, respectively (p < 0.0001) (Osterborg et al 2002).
Positive_regulation (increasing) of Hb
18) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.48 Pain Relevance 0
Interestingly, a direct correlation between the magnitude of the Hb increase and the improvement of QoL was shown by Crawford and colleagues (2002).
Positive_regulation (increase) of Hb
19) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.09 Pain Relevance 0.03
The results showed significant differences between the Iv iron group and the other two groups in Hb increase, 2.4 g/dl, 1.6 g/dl, and 1.5 g/dl, respectively (p = 0.0044 for IV vs. no iron), in response rates, 73%, 45%, and 41% respectively (p = 0.029 for IV vs. no iron).
Positive_regulation (increase) of Hb
20) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.42 Pain Relevance 0

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