INT111462

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 45
Total Number 47
Disease Relevance 19.49
Pain Relevance 15.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
spinal 4
frontal cortex 4
DRG 4
cleavage 2
brain 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 142 100.00 Very High Very High Very High
Anterior cingulate cortex 82 100.00 Very High Very High Very High
withdrawal 17 100.00 Very High Very High Very High
dexamethasone 97 99.98 Very High Very High Very High
Morphine 36 99.98 Very High Very High Very High
Opioid 27 99.84 Very High Very High Very High
Inflammation 121 99.76 Very High Very High Very High
Hippocampus 16 99.68 Very High Very High Very High
Cannabinoid receptor 12 99.48 Very High Very High Very High
Hyperalgesia 17 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 145 100.00 Very High Very High Very High
INFLAMMATION 133 99.76 Very High Very High Very High
Urological Neuroanatomy 5 99.56 Very High Very High Very High
Obesity 343 99.54 Very High Very High Very High
Hyperalgesia 39 99.40 Very High Very High Very High
Targeted Disruption 75 99.34 Very High Very High Very High
Cognitive Disorder 18 99.34 Very High Very High Very High
Nervous System Injury 21 99.24 Very High Very High Very High
Endometriosis 17 99.24 Very High Very High Very High
Small Cell Lung Cancer 8 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extracellular signal-regulated kinase (ERK) 1/2 phosphorylation was increased by 5F203, and inhibition of ERK1/2 phosphorylation abolished the induction of NAG-1 protein expression and increased the stability of NAG-1 mRNA.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of ERK
1) Confidence 0.57 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.77 Pain Relevance 0.22
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of extracellular signal-regulated protein kinase in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
2) Confidence 0.56 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.39 Pain Relevance 1.67
The phosphorylation of ERK was reduced by tyrphostin AG1478, an inhibitor of phosphorylation of the epidermal growth factor receptor (EGFR), and by heparin, which neutralizes heparin-binding epithelial growth factor (HB-EGF), suggesting the involvement of a transactivation process, in which alpha(2)-adrenergic stimulation leads to proteolytic shedding of HB-EGF (and perhaps other EGFR agonists) from transmembrane-spanning precursors.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ERK associated with agonist
3) Confidence 0.55 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834899 Disease Relevance 0.06 Pain Relevance 0.23
Treating endometriotic cells with A771726, PD98059 or U0126 abrogated the phosphorylation of ERK and significantly decreased the cellular proliferation in vitro.
Negative_regulation (abrogated) of Phosphorylation (phosphorylation) of ERK associated with endometriosis and hyperplasia
4) Confidence 0.53 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20821752 Disease Relevance 1.24 Pain Relevance 0.34
Interestingly, mice lacking PAFR showed reduced phosphorylation of extracellular signal-related protein kinase (ERK), an important kinase for the sensitization of primary sensory neurons, in their DRG neurons after formalin injection.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ERK in DRG associated with dorsal root ganglion
5) Confidence 0.52 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17662046 Disease Relevance 1.02 Pain Relevance 1.28
elicited an additive antitumor effect, reduced ERK phosphorylation and
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ERK
6) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.76 Pain Relevance 0.13
The upstream inhibitor of ERK phosphorylation, U0126 (100-400 microg/kg, i.v., 10 min pre-capsaicin), dose-dependently inhibited referred hyperalgesia 3-6 h after capsaicin.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK associated with hyperalgesia and qutenza
7) Confidence 0.43 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941468 Disease Relevance 0.58 Pain Relevance 1.30
Inhibition of ERK phosphorylation in the brain by systemic injection of SL327
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of ERK in brain
8) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.23
The COX-2 inhibitor SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model.
Negative_regulation (suppressing) of Phosphorylation (phosphorylation) of ERK associated with inflammation and cox-2 inhibitor
9) Confidence 0.42 Published 2007 Journal Life Sci. Section Title Doc Link 17822719 Disease Relevance 1.23 Pain Relevance 0.36
Up-regulated mRNA and protein expression of c-fos and fosB was abolished by SB204741, AG1478, and by U0126, an inhibitor of ERK phosphorylation by MAP kinase/ERK kinase.


Negative_regulation (inhibitor) of Phosphorylation (phosphorylation) of ERK
10) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
In addition, spinal ERK phosphorylation following formalin injection was significantly reduced in the DN MEK mice.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ERK in spinal
11) Confidence 0.41 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1382249 Disease Relevance 0.65 Pain Relevance 0.59
Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of ERK in frontal cortex associated with urological neuroanatomy, withdrawal and morphine
12) Confidence 0.41 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.39 Pain Relevance 1.67
Phosphorylation of ERK1/2 in neurons of the ACC induced by intraplantar injection of either formalin or CFA was significantly decreased in GluA1-/- mice in comparison with their WT mice (see Fig. 8A for typical example and Fig. 8B for summary of densitometric analysis).
Negative_regulation (decreased) of Phosphorylation (Phosphorylation) of ERK1/2 in neurons associated with anterior cingulate cortex
13) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.74 Pain Relevance 0.49
U0126 (2.63 nmol/mouse, i.h.) impaired memory formation and training-dependent phosphorylation of ERK2 in the hippocampus.
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of ERK2 in hippocampus associated with hippocampus
14) Confidence 0.39 Published 2010 Journal Neurobiol Learn Mem Section Abstract Doc Link 20026233 Disease Relevance 0.55 Pain Relevance 0.66
Specifically, key protein intermediates may be physically associated with endogenous RTKs in HEK-293 cells, and therefore, down-regulation of the EGFR may negatively affect ERK phosphorylation by opioids.
Spec (may) Negative_regulation (affect) of Phosphorylation (phosphorylation) of ERK associated with opioid
15) Confidence 0.39 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.06 Pain Relevance 0.16
Interestingly, mice lacking PAFR showed reduced phosphorylation of extracellular signal-related protein kinase (ERK), an important kinase for the sensitization of primary sensory neurons, in their DRG neurons after formalin injection.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of extracellular signal-related protein kinase in DRG associated with dorsal root ganglion
16) Confidence 0.38 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17662046 Disease Relevance 1.02 Pain Relevance 1.28
We found here for the first time that nerve injury produces a sustained and significant reduction in protein levels of phosphorylated-ERK and -p38 in cytosolic preparations of the mouse lower midbrain.
Negative_regulation (reduction) of Phosphorylation (phosphorylated) of ERK in midbrain associated with nervous system injury and midbrain
17) Confidence 0.37 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.34 Pain Relevance 1.22
Consistent with AT1R-mediated ERK activation in the diabetic retina (Fig. 1), angiotensin II administration induced the phosphorylation of ERK in the neuronal cells, which was significantly (P < 0.05) inhibited by AT1R blockade with telmisartan or valsartan (Fig. 5A and B).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of ERK in neuronal associated with diabetes mellitus
18) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.19 Pain Relevance 0
RESULTS: ERK(1/2) phosphorylation was abolished by SB204741, a universal 5-HT(2) receptor antagonist, and in 5-HT(2B) receptor-depleted cells, but unaffected by 5-HT(2A) or 5-HT(2C) receptor antagonists (M100907 and SB242084).
Negative_regulation (abolished) of Phosphorylation (phosphorylation) of ERK
19) Confidence 0.37 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
Phosphorylation of ERK(1/2) and EGFRs was abolished by AG 1478, an inhibitor of EGFR tyrosine kinases, and GM 6001, an inhibitor of Zn-dependent metalloproteinases, suggesting growth factor "shedding" and transactivation of EGFRs.
Negative_regulation (abolished) of Phosphorylation (Phosphorylation) of ERK
20) Confidence 0.37 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0

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