INT111470

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 11.42
Pain Relevance 5.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EPRS) RNA binding (EPRS) protein complex assembly (EPRS)
ligase activity (EPRS) cytoplasm (EPRS)
Anatomy Link Frequency
cleavage 2
visceral 1
smooth muscle 1
urothelial cells 1
bladder 1
EPRS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 254 99.88 Very High Very High Very High
Peripheral nervous system 6 99.20 Very High Very High Very High
antagonist 14 99.12 Very High Very High Very High
Pain 25 98.00 Very High Very High Very High
Arthritis 12 95.32 Very High Very High Very High
Inflammatory response 42 94.84 High High
agonist 83 94.80 High High
Potency 4 94.36 High High
Visceral pain 1 87.00 High High
Osteoarthritis 132 83.28 Quite High
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 1 100.00 Very High Very High Very High
Disease 31 99.92 Very High Very High Very High
Nervous System Injury 2 99.92 Very High Very High Very High
INFLAMMATION 305 99.88 Very High Very High Very High
Injury 26 99.54 Very High Very High Very High
Cancer 28 99.48 Very High Very High Very High
Cardiovascular Disease 2 99.04 Very High Very High Very High
Adult Respiratory Distress Syndrome 42 98.94 Very High Very High Very High
Non-genital Cutaneous Warts 3 98.72 Very High Very High Very High
Pain 19 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protease signaling in tissues depends on the generation and release of proteases, availability of cofactors, presence of protease inhibitors, and activation and inactivation of PARs.
Positive_regulation (activation) of PARs
1) Confidence 0.44 Published 2004 Journal Physiol. Rev. Section Abstract Doc Link 15044683 Disease Relevance 0.58 Pain Relevance 0.38
Proteinase activated receptors (PARs) are a newly identified family of G-protein-coupled receptors that are activated by proteinases released into tissues during inflammation.
Positive_regulation (activated) of PARs associated with inflammation
2) Confidence 0.40 Published 2009 Journal Inflamm. Res. Section Abstract Doc Link 19184346 Disease Relevance 0.63 Pain Relevance 0.39
By activating PARs, these proteinases have the potential to modulate joint inflammation and pain by a highly targeted and selective receptor pathway.
Positive_regulation (activating) of PARs in joint associated with pain, inflammation and arthritis
3) Confidence 0.40 Published 2009 Journal Inflamm. Res. Section Abstract Doc Link 19184346 Disease Relevance 0.77 Pain Relevance 0.50
This review summarizes evidence that proteinases, through activation of PARs, interact with the peripheral nervous system (PNS), playing roles in neurogenic inflammation, pain perception, secretory and motor functions, as well as in the response to nerve injuries.
Positive_regulation (activation) of PARs in PNS associated with pain, nervous system injury, inflammation, peripheral nervous system and neurogenic inflammation
4) Confidence 0.40 Published 2003 Journal Trends Neurosci. Section Abstract Doc Link 12948661 Disease Relevance 0.29 Pain Relevance 0.27
Furthermore, mRNA-levels of eight different aminoacyl-tRNA synthetases (CARS, EPRS, GARS, IARS, MARS, SARS, WARS, YARS) were upregulated.


Positive_regulation (upregulated) of EPRS associated with severe acute respiratory syndrome
5) Confidence 0.37 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.30 Pain Relevance 0
Activation of PARs interferes with numerous physiological events that are under tight neural control, in addition to modulating nerve survival.
Positive_regulation (Activation) of PARs in nerve
6) Confidence 0.35 Published 2003 Journal Trends Neurosci. Section Abstract Doc Link 12948661 Disease Relevance 0.29 Pain Relevance 0.28
Apart from activating PARs to cause their physiological effects in tissues, proteinases can also mediate cell signalling via a number of other mechanisms, including the activation of growth factor receptors, like the one for insulin.
Positive_regulation (activating) of PARs
7) Confidence 0.33 Published 2005 Journal Swiss Med Wkly Section Abstract Doc Link 16208579 Disease Relevance 0.39 Pain Relevance 0.15
The proteases that activate PARs are often generated and released during injury and inflammation, and activated PARs orchestrate tissue responses to injury, including hemostasis, inflammation, pain, and repair.
Positive_regulation (activated) of PARs associated with pain, inflammation and injury
8) Confidence 0.29 Published 2005 Journal Neuromolecular Med. Section Abstract Doc Link 16052040 Disease Relevance 0.76 Pain Relevance 0.39
However, in many tissues the proteases that activate PARs are unknown.
Positive_regulation (activate) of PARs
9) Confidence 0.22 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14726524 Disease Relevance 0.20 Pain Relevance 0.27
PARs are activated by a serine-dependent cleavage generating a tethered activating ligand.
Positive_regulation (activated) of PARs in cleavage
10) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246240 Disease Relevance 0.53 Pain Relevance 0.36
PARs are widely distributed in the mammalian body, especially throughout the alimentary systems, and play various roles in physiological/pathophysiological conditions, i.e., modulation of salivary, gastric, or pancreatic glandular exocrine secretion, gastrointestinal smooth muscle motility, gastric mucosal cytoprotection, suppression/facilitation of visceral pain and inflammation, etc.
Positive_regulation (distributed) of PARs in smooth muscle associated with visceral pain and inflammation
11) Confidence 0.13 Published 2005 Journal Yakugaku Zasshi Section Abstract Doc Link 15930817 Disease Relevance 0.16 Pain Relevance 0.41
The cell membrane PARs are restored from the intracellular pool [5].
Positive_regulation (restored) of PARs
12) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.66 Pain Relevance 0.44
Activation of PARs, particularly of PAR-1 and -2, modulates intestinal functions, such as gastrointestinal motility, visceral nociception, mucosal inflammatory response, and epithelial functions (intestinal secretion and permeability).
Positive_regulation (Activation) of PARs in visceral associated with nociception and inflammatory response
13) Confidence 0.10 Published 2005 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16185159 Disease Relevance 0.37 Pain Relevance 0.19
Protease-activated receptors (PARs) are a family of four G-protein-coupled receptors (PAR-1 to PAR-4) activated by the proteolytic cleavage of their N-terminal extracellular domain.
Positive_regulation (activated) of PARs in cleavage
14) Confidence 0.06 Published 2005 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16185159 Disease Relevance 0.27 Pain Relevance 0.11
In addition to the J82 cell line, expression of PARs in RT4 bladder papilloma cells was inferred based on findings that RT4 cells respond to activators of PARs such as thrombin, tryptase, and PAR-activating peptides[30].
Positive_regulation (activators) of PARs in RT4 associated with non-genital cutaneous warts and carcinoma
15) Confidence 0.05 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.25 Pain Relevance 0.18
Coagulopathy not only adds another pathological feature to ALI/ARDS, but also leads to inflammatory signals through the activation of protease-activated receptors (PARs) [7], [8], [9], indicating an extensive cross-talk and reciprocal amplification between coagulation and inflammatory cascades [10].
Positive_regulation (activation) of PARs associated with coagulation disorder, inflammation and adult respiratory distress syndrome
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 2.03 Pain Relevance 0.25
Although information regarding the presence of PARs in human urothelial cells is scanty, indirect evidence indicates that human cancer urothelial cells, such as J82, augment the conversion of prothrombin to thrombin, a key activator of PARs [28].
Positive_regulation (activator) of PARs in urothelial cells associated with cancer
17) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.61 Pain Relevance 0.13
Next, we determined whether activation of PARs in mice would induce bladder inflammation.
Spec (whether) Positive_regulation (activation) of PARs in bladder associated with inflammation
18) Confidence 0.04 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.24 Pain Relevance 0.45
Both thrombin (capable of activating Gq through protease-activated receptors (PARs) [34]) and lysophosphatidic acid (LPA) (capable of activating Gq through endothelium differentiation gene (EDG) receptors) are strong stimulators of cultured ASM DNA synthesis and cell proliferation.
Positive_regulation (activating) of PARs in endothelium
19) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.14
Protease-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain-receptors activated by specific proteases, consisting of four family members.
Positive_regulation (activated) of PARs
20) Confidence 0.01 Published 2003 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12835535 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox