INT111475

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.08
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CES2) catabolic process (CES2)
Anatomy Link Frequency
intestine 2
CES2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 4 71.36 Quite High
Analgesic 1 68.20 Quite High
lidocaine 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 82.00 Quite High
Heart Disease 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distal promoter is active in both orientations, suggesting its potential role in the transcription of another gene, CGI-128, located immediately upstream to the distal promoter in the opposite direction with respect to CES2.
Transcription (transcription) of CES2
1) Confidence 0.69 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12835618 Disease Relevance 0.08 Pain Relevance 0.10
In addition to the extensive sequence similarities observed for the human CES2 and opossum CES2Like products, there are strong similarities in predicted secondary structures for these enzymes suggesting that the ??
Transcription (observed) of CES2
2) Confidence 0.69 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
RT-PCR expression studies demonstrated that the opossum CES1, CES2.2 and CES2.3 genes are transcribed in opossum liver and intestine, whereas the opossum CES2.1 gene was expressed in liver and not intestine.
Transcription (transcribed) of CES2 in intestine
3) Confidence 0.53 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0
RT-PCR expression studies demonstrated that the opossum CES1, CES2.2 and CES2.3 genes are transcribed in opossum liver and intestine, whereas the opossum CES2.1 gene was expressed in liver and not intestine.
Transcription (transcribed) of CES2.2 in intestine
4) Confidence 0.53 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2266714 Disease Relevance 0 Pain Relevance 0

General Comments

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