INT111477

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2010
Negated 22
Speculated 2
Reported most in Body
Documents 90
Total Number 93
Disease Relevance 86.76
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT7) nucleolus (KRT7) structural molecule activity (KRT7)
nucleus (KRT7) cytoskeleton organization (KRT7) cytoplasm (KRT7)
Anatomy Link Frequency
thyroid 4
epithelial cells 3
stomach 2
smooth muscle 1
intestinal epithelium 1
KRT7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 172 99.18 Very High Very High Very High
anesthesia 9 93.96 High High
backache 20 93.92 High High
imagery 66 93.04 High High
Pain 35 92.96 High High
Bile 82 92.44 High High
Angina 2 90.28 High High
Dysuria 1 85.28 High High
Crohn's disease 2 83.76 Quite High
palliative 27 82.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 3189 100.00 Very High Very High Very High
Adenocarcinoma 1477 99.98 Very High Very High Very High
Mucinous Adenocarcinoma 11 99.98 Very High Very High Very High
Metastasis 647 99.96 Very High Very High Very High
Thyroid Neoplasm 10 99.90 Very High Very High Very High
Ependymoma 259 99.88 Very High Very High Very High
Carcinoma 1020 99.84 Very High Very High Very High
Neuroendocrine Cancer 124 99.84 Very High Very High Very High
Mesothelioma 102 99.72 Very High Very High Very High
Renal Cancer 332 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What was interesting was the immunophenotype of the lesion: cytokeratin (CK) 20 expression was very focal in the adenocarcinoma component and negative in the neuroendocrine carcinoma, while CK 7 was expressed strongly in the adenocarcinoma and only focally in the neuroendocrine component.
Gene_expression (expressed) of CK 7 associated with adenocarcinoma and neuroendocrine cancer
1) Confidence 0.74 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16508780 Disease Relevance 1.32 Pain Relevance 0.08
Later, the immunohistochemical examination revealed that cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF-1) were distinctly detected but cytokeratin 20 (CK20) never expressed.
Gene_expression (detected) of CK7 in thyroid
2) Confidence 0.74 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.20 Pain Relevance 0.09
Later, the immunohistochemical examination revealed that cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF-1) were distinctly detected but cytokeratin 20 (CK20) never expressed.
Gene_expression (detected) of cytokeratin 7 in thyroid
3) Confidence 0.74 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.21 Pain Relevance 0.09
4 integrin subunit) and RM-derived cell lines (e.g. ezrin, bFGF, the tPA and uPA plasminogen activators, N-cadherin, cytokeratin 7), and others that were reduced in malignant cells (TRAIL, cytokeratin 19, ?
Gene_expression (ezrin) of cytokeratin 7 associated with malignant neoplastic disease
4) Confidence 0.65 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.86 Pain Relevance 0.04
Classically, adenocarcinoma of the lung, breast ovary and omentum are CK7 positive and CK20 negative, while adenocarcinoma of colorectal origin tends to have the opposite (CK7 negative and CK20 positive) [4,15].
Neg (negative) Gene_expression (negative) of CK7 in ovary associated with adenocarcinoma
5) Confidence 0.65 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092434 Disease Relevance 0.85 Pain Relevance 0
Nor did the result for KRT7 (cytokeratin 7), which has been shown to be overexpressed in Chr [20].
Gene_expression (overexpressed) of cytokeratin 7 associated with carcinoma
6) Confidence 0.65 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.08 Pain Relevance 0
Recently, Chhieng et al. described that an adenocarcinoma was likely a primary lung tumor when it was of the CK7 positive/CK20 negative and TTF-1 positive phenotype [1].
Neg (negative) Gene_expression (positive) of CK7 in lung associated with adenocarcinoma and lung cancer
7) Confidence 0.64 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1821329 Disease Relevance 1.23 Pain Relevance 0.08
Sections were stained routinely (H&E, trichrome, reticulin) as well as immunostained for detection of CK7, CK19, ?
Gene_expression (detection) of CK7
8) Confidence 0.64 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC166154 Disease Relevance 0.40 Pain Relevance 0.09
The ileocecal lesion was diagnosed as a recurrence because of the histological findings, which included mucosal preservation, a similarity with the histologic type of stomach carcinoma, and atypical immunoreactivity for primary colon carcinoma; the lesion was negative for both cytokeratin 7 and cytokeratin 20.
Neg (negative) Gene_expression (negative) of cytokeratin 7 in colon associated with colon cancer, stomach cancer and recurrence
9) Confidence 0.60 Published 2004 Journal Acta Med. Okayama Section Abstract Doc Link 15551760 Disease Relevance 0.94 Pain Relevance 0.16
However, the cells were all negative for cytokeratin 7 and EMA.
Neg (negative) Gene_expression (negative) of cytokeratin 7
10) Confidence 0.57 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430707 Disease Relevance 1.28 Pain Relevance 0
Nor did the result for KRT7 (cytokeratin 7), which has been shown to be overexpressed in Chr [20].
Gene_expression (overexpressed) of KRT7 associated with carcinoma
11) Confidence 0.56 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.08 Pain Relevance 0
The possibility of prostatic metastasis was considered and confirmed on immunohistochemical staining for PSA (Figure 2) and, given this, stains for CK7, CK20 and CDX2 immunoprofile were considered unnecessary.
Gene_expression (immunoprofile) of CK7 associated with metastasis
12) Confidence 0.51 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1779271 Disease Relevance 0.83 Pain Relevance 0
The luminal cells were strongly immunoreactive with CK7 and with CD117 (Fig. 11).
Gene_expression (immunoreactive) of CK7
13) Confidence 0.44 Published 2008 Journal Head Neck Pathol Section Body Doc Link PMC2807538 Disease Relevance 0.41 Pain Relevance 0
All of the freshly isolated cells in the cytospin preparations expressed CK7.
Gene_expression (expressed) of CK7
14) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773740 Disease Relevance 0.07 Pain Relevance 0
In contrast, only about two thirds of the tarsal and bulbar cells expressed CK7 by flow cytometry.
Gene_expression (expressed) of CK7
15) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773740 Disease Relevance 0.07 Pain Relevance 0
An immunohistochemical panel showed the tissue to be cytokeratin 20 (CK-20) positive, cytokeratin 7 (CK-7) negative and villin negative, thus in keeping with a colorectal primary tumour.
Gene_expression (negative) of cytokeratin 7 associated with cancer
16) Confidence 0.39 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1716166 Disease Relevance 1.53 Pain Relevance 0.10
An immunohistochemical panel showed the tissue to be cytokeratin 20 (CK-20) positive, cytokeratin 7 (CK-7) negative and villin negative, thus in keeping with a colorectal primary tumour.
Gene_expression (negative) of CK-7 associated with cancer
17) Confidence 0.39 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1716166 Disease Relevance 1.52 Pain Relevance 0.10
For the detection of CK7, the slides were treated as described above but without antigen retrieval, and incubated overnight at 4°C with mouse anti-human CK7, clone OV-TL 12/30 (Dakocytomation), diluted 1:25 in PBS with 1% bovine serum albumin.
Gene_expression (detection) of CK7
18) Confidence 0.37 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0 Pain Relevance 0
The supernatant was removed and cells were incubated with CK7-FITC antibody (10 ?
Gene_expression (incubated) of CK7
19) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773740 Disease Relevance 0.30 Pain Relevance 0
K8, K18, K19, and K7 are expressed in all cell layers.
Gene_expression (expressed) of K7
20) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.02 Pain Relevance 0

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