INT111482

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 23
Total Number 46
Disease Relevance 13.74
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd24a)
Anatomy Link Frequency
precursor cells 5
neurons 3
epithelial cell 2
dentate gyrus 1
neuronal precursors 1
Cd24a (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 560 99.80 Very High Very High Very High
Central nervous system 184 99.66 Very High Very High Very High
cINOD 136 90.72 High High
antagonist 1 73.60 Quite High
cerebral cortex 23 70.68 Quite High
lumbar region 4 56.08 Quite High
neurotrophin 3 184 28.68 Quite Low
imagery 30 5.00 Very Low Very Low Very Low
ketamine 28 5.00 Very Low Very Low Very Low
anesthesia 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 299 99.70 Very High Very High Very High
Adhesions 16 98.94 Very High Very High Very High
Cytomegalovirus Infection 1288 98.28 Very High Very High Very High
Peripheral Arterial Disease 14 97.04 Very High Very High Very High
Infection 1104 96.72 Very High Very High Very High
Cancer 2410 95.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 92 94.96 High High
Cognitive Disorder 23 93.60 High High
Neurodegenerative Disease 138 90.44 High High
Immunization 9 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD24 is expressed by precursors of neuronal cells in the developing brain [16] and by neuroblasts from two adult neurogenic zones: the subventricular zone (SVZ) bordering the lateral ventricle, and the dentate gyrus of the hippocampal formation [25].
Gene_expression (expressed) of CD24 in dentate gyrus
1) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.08 Pain Relevance 0
These studies indicate that human CNS precursor cells expressing high levels of the surface antigen CD133 (CD133+/hi), with little or no CD24 (CD24?
Gene_expression (expressing) of CD24 in precursor cells associated with central nervous system
2) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.46 Pain Relevance 0.09
High CD24 expression has been used to identify transit-amplifying cells [15], as well as differentiated neurons [16], and CD24 is required for terminal differentiation of neuronal progenitors [17].
Gene_expression (expression) of CD24 in neurons
3) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.44 Pain Relevance 0
It is well documented in the literature that hi CD24 expression is associated with neuronal precursor cells or neuroblasts.
Gene_expression (expression) of CD24 in neuroblasts
4) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.56 Pain Relevance 0
These studies indicate that human CNS precursor cells expressing high levels of the surface antigen CD133 (CD133+/hi), with little or no CD24 (CD24?
Gene_expression (expressing) of CD24 in precursor cells associated with central nervous system
5) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.46 Pain Relevance 0.09
Interestingly, we were unable to detect viral infection in cells that expressed CD24 at low levels.
Gene_expression (expressed) of CD24 associated with viral infection
6) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.56 Pain Relevance 0
In fact, high CD24 expression has been used to identify transit-amplifying cells [15], as well as differentiated neurons [16], and CD24 is required for terminal differentiation of neuronal progenitors [17].
Gene_expression (expression) of CD24 in neurons
7) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.29 Pain Relevance 0.09
Our findings indicated that neuronal precursors expressing hi CD24 are predominant target cells for the virus.
Gene_expression (expressing) of CD24 in neuronal precursors
8) Confidence 0.72 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.57 Pain Relevance 0
Another mammary progenitor-associated marker, CD61 (integrin beta 3) [36], was detected on a large fraction of G-2 cells (Figure 7D, left) and is also co-expressed with CD24a and CD49f (Figure 7D, right).
Gene_expression (expressed) of CD24a
9) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.17 Pain Relevance 0
After 3 days in culture, the DiI-positive cells (Figure 11A and B, left) were analyzed by FACS for expression of CD24a and CD49f (Figure 11A and B, right).
Spec (analyzed) Gene_expression (expression) of CD24a
10) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
In contrast to the report by Cho et al. [33], we observed that Thy1high cells are mainly contained within the CD24alow/Sca1high subset (Figure 8A); however a small fraction of cells co-expressed Thy1 and CD24a (Figure 8B).
Gene_expression (co-expressed) of CD24a
11) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.08 Pain Relevance 0
While the RNA levels of the Cd24a and Cd49f genes positively correlated with increased cell density, expression of the Sca1 decreased as a function of cell density (Figure 10C).
Gene_expression (levels) of Cd24a
12) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
The transcription levels of Cd24a and Cd49f genes are low, but clearly detectable in the Thy1high subset (Figure S4C).
Gene_expression (levels) of Cd24a
13) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
Cellular subsets sorted according to expression of CD24a, CD49f, CD61, Epcam, Sca1, and Thy1 cell surface proteins, or metabolic markers (e.g.
Gene_expression (expression) of CD24a
14) Confidence 0.71 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.64 Pain Relevance 0
Therefore, we collectively termed the fraction of G-2 cells co-expressing these cell membrane associated proteins as the CD24ahigh subset.
Gene_expression (expressing) of CD24ahigh
15) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.16 Pain Relevance 0
To substantiate this idea, 5×103 and 5×104 FACS-sorted CD24alow/CD49flow G-2 cells were plated per well, and after 5 days in culture expression of the Cd24a, Cd49f and Sca1 genes was quantified by qPCR.
Gene_expression (expression) of Cd24a
16) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
A large fraction of G-2 cells is positive for Epcam (epithelial cell adhesion molecule) [31], [32] (Figure 7C, left), which is co-expressed with CD24a and CD49f (integrin alpha 6) proteins [30], [33]–[35] (Figure 7C, right).
Gene_expression (expressed) of CD24a in epithelial cell associated with adhesions
17) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.19 Pain Relevance 0
Mice were immunized against human serum albumin (HSA), and serum anti-HSA antibody levels were measured (in micrograms per milliliter) using an enzyme-linked immunosorbent assay (ELISA).
Gene_expression (immunized) of HSA
18) Confidence 0.65 Published 2003 Journal Phys Ther Section Body Doc Link 12837125 Disease Relevance 0.09 Pain Relevance 0
In contrast to the report by Cho et al. [33], we observed that Thy1high cells are mainly contained within the CD24alow/Sca1high subset (Figure 8A); however a small fraction of cells co-expressed Thy1 and CD24a (Figure 8B).
Gene_expression (expressed) of CD24a
19) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.09 Pain Relevance 0
The CD24alow/CD49flow subset was labeled with the lipophilic dye DiI and 1×104 labeled cells were either cultured separately, or were plated at a 1?
Gene_expression (subset) of CD24a
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0

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